Epigenetic regulation of RNA sensors: Sentinels of immune response

Khan, Mohammad Imran; Nur, Suza Mohammad; Adhami, Vaqar M.; Mukhtar, Hasan

doi:10.1016/j.semcancer.2020.12.028

Cited by 6 publications

(3 citation statements)

References 162 publications

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“…The NA-based nanosensor is an activatable sensor, which not only targets NA or proteins (e.g. aptamer), but can also combine antisense oligonucleotides or interfering RNAs to serve both therapeutic and diagnostic purposes (theragnostic) ( Liu et al, 2017 ; Xie et al, 2020 ; He et al, 2021 ; Khan et al, 2021 ). Use of an NA-based sensor as a screening tool to detect COVID-19 produces highly specific and sensitive results ( Dronina et al, 2021 ; Zhang M et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Advances in the use of nanomaterials for nucleic acid detection in point-of-care testing devices: A review

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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The outbreak of the coronavirus (COVID-19) has heightened awareness of the importance of quick and easy testing. The convenience, speed, and timely results from point-of-care testing (POCT) in all vitro diagnostic devices has drawn the strong interest of researchers. However, there are still many challenges in the development of POCT devices, such as the pretreatment of samples, detection sensitivity, specificity, and so on. It is anticipated that the unique properties of nanomaterials, e.g., their magnetic, optical, thermal, and electrically conductive features, will address the deficiencies that currently exist in POCT devices. In this review, we mainly analyze the work processes of POCT devices, especially in nucleic acid detection, and summarize how novel nanomaterials used in various aspects of POCT products can improve performance, with the ultimate aims of offering new ideas for the application of nanomaterials and the overall development of POCT devices.

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Section: Introductionmentioning

confidence: 99%

Advances in the use of nanomaterials for nucleic acid detection in point-of-care testing devices: A review

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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“…Mounting evidence supports that epigenetic modifications are associated with the occurrence, development, and resolution of inflammation via remodeling immune/non-immune cells and the microenvironment ( 5 , 6 ), thus promoting or repressing the progression of many inflammatory diseases such as diabetes ( 7 – 9 ), rheumatoid arthritis (RA) ( 10 , 11 ), asthma ( 12 , 13 ), fatty liver diseases ( 14 , 15 ), and cancer ( 16 – 18 ). Mechanically, inflammation can induce changes in the epigenetic landscape in an inflammatory microenvironment ( 6 , 19 ), and epigenetic modifications can in turn maintain and promote the development of inflammation by regulating the expression of various immune components ( 20 , 21 ). With studies on the development of epigenetic modifications in inflammation and with rapid research progress on mechanisms and drug discovery, some star targets (lysine-specific demethylases ( 22 , 23 ), BRD4 ( 16 , 17 , 24 ), EZH2-EED protein-protein interaction ( 25 , 26 ), and HDACs ( 27 )) have been used in the diagnosis or treatment of inflammatory diseases in cellulo and in vivo .…”

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confidence: 99%

Editorial: Community series in epigenetics of the immune component of inflammation-volume II

Liu,

Zhong,

Wang

et al. 2023

Front. Immunol.

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“…Inflammation often hijacks various epigenetic mechanisms to promote occurrence and development of these diseases ( 6 , 7 ). In turn, epigenetic modifications also mediate pathologic development of inflammation by regulating immune components in inflammatory microenvironments ( 8 , 9 ). Numerous preclinical and clinical studies showed that epigenetic modulators, including KDM5 inhibitors ( 10 ), LSD1 inhibitors ( 11 ), HDAC inhibitors ( 12 ), EZH2 inhibitors ( 13 , 14 ), and BET inhibitors ( 4 , 5 , 15 ) exhibit anti–inflammatory activities in vitro and in vivo .…”

mentioning

confidence: 99%