Epigenetic switch from repressive to permissive chromatin in response to cold stress

Park, Junghoon; Lim, Chaehun; Shen, Mingzhe; Park, Hyojin; Cha, Joon‐Yung; Iniesto, Elisa; Rubio, Vicente; Mengiste, Tesfaye; Zhu, Jian‐Kang; Bressan, Ray A.; Lee, Sang Yeol; Lee, Byeong-ha; Jin, Jing Bo; Pardo, José M.; Kim, Woe‐Yeon; Yun, Dae‐Jin

doi:10.1073/pnas.1721241115

Cited by 169 publications

(220 citation statements)

References 70 publications

(96 reference statements)

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“…Consistent with the previous qPCR-based analysis of COR15A regulation [17], 5 days after 24 h cold priming none of the reference genes for epigenetic cold memories, namely COR15A, COR47 or FLC (Suppl. Table 2) [74,75], showed priming-dependent regulation in the present study.…”

Section: Discussionsupporting

confidence: 72%

“…Various studies suggest an epigenetic memory, such as histone and DNA (de-)acetylation or (de-)methylation, for storing information on thermal stress events [15,[71][72][73]. For example, COR15A (At2g42540) and COR47 (At1g20440) are stronger expressed, if the second cold stimulus quickly follows the first one [74]. The majority of the cold-induced histone marks, however, is metastable.…”

Section: Discussionmentioning

confidence: 99%

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Cold priming uncouples light- and cold-regulation of gene expression in Arabidopsis thaliana

Bittner

Buer

Baier

2020

Preprint

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Background The majority of stress-sensitive genes responds to cold and highlight in the same direction, if plants face the stresses for the first time. As shown recently for a small selection of genes of the core environmental stress response cluster, pre-treatment of Arabidopsis thaliana with a 24 h long 4 °C cold stimulus modifies cold regulation of gene expression for up to a week at 20 °C, although the primary cold effects are reverted within the first 24 h. Such memory based regulation is called priming. Here, we show the effect of 24 h cold priming on cold regulation of gene expression on a transcriptome-wide scale and test if and how cold priming effects light regulation of gene expression.Results 304 genes were differently regulated between cold-primed and non-primed plants after a second 24 h long 4 °C cold treatment. After triggering the plants with a heat-filtered highlight stimulus (800 µmol quanta m -2 s -1 ), 1011 genes showed priming dependent regulation. Only 32 of

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Section: Discussionsupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Cold priming uncouples light- and cold-regulation of gene expression in Arabidopsis thaliana

Bittner

Buer

Baier

2020

Preprint

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“…In addition to histone methylation, other histone modifications also play important roles in the cold stress response. Histone acetylation is enriched in the bodies of a number of cold‐responsive genes (Zhu et al 2008; Park et al 2018). This process is dynamically regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs).…”

Section: Epigenetic Regulation During the Extreme‐temperature Stress mentioning

confidence: 99%

“…Recent studies have indicated that another HD2 family deacetylase, HD2C in Arabidopsis , is involved in CBF‐dependent transcriptional activation of COR genes upon cold stress. HD2C is a target of HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 15 (HOS15)‐mediated degradation under cold treatment (Park et al 2018). HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 15 is a component of the CULLIN 4 (CUL4)‐based E3 ubiquitin ligase complex (Zhu et al 2008).…”

Section: Epigenetic Regulation During the Extreme‐temperature Stress mentioning

confidence: 99%

Epigenetic regulation in plant abiotic stress responses

Chang

Jiang

et al. 2020

JIPB

340

225

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In eukaryotic cells, gene expression is greatly influenced by the dynamic chromatin environment. Epigenetic mechanisms, including covalent modifications to DNA and histone tails and the accessibility of chromatin, create various chromatin states for stress-responsive gene expression that is important for adaptation to harsh environmental conditions. Recent studies have revealed that many epigenetic factors participate in abiotic stress responses, and various chromatin modifications are changed when plants are exposed to stressful environments. In this review, we summarize recent progress on the cross-talk between abiotic stress response pathways and epigenetic regulatory pathways in plants. Our review focuses on epigenetic regulation of plant responses to extreme temperatures, drought, salinity, the stress hormone abscisic acid, nutrient limitations and ultraviolet stress, and on epigenetic mechanisms of stress memory.

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“…At the heart of this regulation is the chaperone activity of the cold shock protein cspA and its 5'UTR that acts as a thermosensor (Giuliodori et al, 2010) and auto-regulates its own abundance in a temperature-dependent way . In plants, cold adaptation is more complex, involving temperature-induced adjustments of the chromatin (Zeng et al, 2019;Park et al, 2018), transcriptional (Nagano et al, 2019), pre-mRNA processing (Calixto et al, 2018), post-transcriptional and posttranslational landscapes (Zhu, 2016). The transcriptional response to cold acclimatization in plants is beginning to be unraveled and entire signaling networks such as the C-repeat binding transcription factor (CBFs) regulon have been exposed (Zhao et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Cold induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm

Fischl

McManus

Oldenkamp

et al. 2020

Preprint

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Cooling patients to sub-physiological temperatures is an integral part of modern medicine. We show that cold exposure induces temperature-specific changes to the higher-order chromatin and gene expression profiles of human cells. These changes are particularly dramatic at 18°C, a temperature synonymous with that experienced by patients undergoing controlled deephypothermia during surgery. Cells exposed to 18°C exhibit largely nuclear-restricted transcriptome changes. These include the nuclear accumulation of core circadian clock suppressor gene transcripts, most notably REV-ERBα. This response is accompanied by compaction of higher-order chromatin and hindrance of mRNPs from engaging nuclear pores.Rewarming reverses chromatin compaction and releases the transcripts into the cytoplasm, triggering a pulse of suppressor gene proteins that resets the circadian clock. We show that cold-induced upregulation of REV-ERBα alone is sufficient to trigger this resetting. Our findings uncover principles of the cellular cold-response that must be considered for current and future applications involving therapeutic deep-hypothermia.

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Epigenetic switch from repressive to permissive chromatin in response to cold stress

Cited by 169 publications

References 70 publications

Cold priming uncouples light- and cold-regulation of gene expression in Arabidopsis thaliana

Cold priming uncouples light- and cold-regulation of gene expression in Arabidopsis thaliana

Epigenetic regulation in plant abiotic stress responses

Cold induced chromatin compaction and nuclear retention of clock mRNAs resets the circadian rhythm

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