Epigenetic Transgenerational Inheritance

Blanco, Joan; Sánchez, Cristina Camprubí

doi:10.1007/978-3-030-21664-1_4

Cited by 17 publications

(17 citation statements)

References 112 publications

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“…Additional animal models have shown similar results, reporting that epigenetic alterations at PEG3 and H19 can occur in sperm cells in offspring from diabetic and/or obese mice (Ge et al, 2014). These studies, when taken together, highlight that both defective DNA methylation and imprinting marks may be transferred through generations, potentially affecting the health of adult offspring (Grossniklaus et al, 2013;Ge et al, 2014;Soubry et al, 2015;Blanco Rodríguez and Camprubí Sánchez, 2019). However, this assumption has been questioned in a recent meta-analysis of coordinated epigenome-wide association studies of paternal prenatal body mass index (BMI) in relation to DNA methylation (Sharp et al, 2021).…”

Section: Lifestyle Factorsmentioning

confidence: 67%

Epigenetics of Male Infertility: The Role of DNA Methylation

Rotondo

Lanzillotti

Mazziotta

et al. 2021

Front. Cell Dev. Biol.

114

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In recent years, a number of studies focused on the role of epigenetics, including DNA methylation, in spermatogenesis and male infertility. We aimed to provide an overview of the knowledge concerning the gene and genome methylation and its regulation during spermatogenesis, specifically in the context of male infertility etiopathogenesis. Overall, the findings support the hypothesis that sperm DNA methylation is associated with sperm alterations and infertility. Several genes have been found to be differentially methylated in relation to impaired spermatogenesis and/or reproductive dysfunction. Particularly, DNA methylation defects of MEST and H19 within imprinted genes and MTHFR within non-imprinted genes have been repeatedly linked with male infertility. A deep knowledge of sperm DNA methylation status in association with reduced reproductive potential could improve the development of novel diagnostic tools for this disease. Further studies are needed to better elucidate the mechanisms affecting methylation in sperm and their impact on male infertility.

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Section: Lifestyle Factorsmentioning

confidence: 67%

Epigenetics of Male Infertility: The Role of DNA Methylation

Rotondo

Lanzillotti

Mazziotta

et al. 2021

Front. Cell Dev. Biol.

114

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“…Histone retention in sperm, a mechanism that is tightly intertwined with the establishment of the sperm epigenome, seems to have an impact in inter-and trans-generational epigenetic inheritance. Any alteration in the sperm epigenome seem to be enough to produce altered inherited epigenetic traits (Champroux et al, 2018;Blanco Rodriguez and Camprubi Sanchez, 2019;Cavalli and Heard, 2019;Hart and Tadros, 2019;King et al, 2019;Perez and Lehner, 2019;Shukla et al, 2019;Lewens, 2020).…”

Section: Altered Histone Retention and Transgenerational Inheritancementioning

confidence: 99%

The Interplay Between Replacement and Retention of Histones in the Sperm Genome

Torres-Flores

Hernández‐Hernández

2020

Front. Genet.

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The genome of eukaryotes is highly organized within the cell nucleus, this organization per se elicits gene regulation and favors other mechanisms like cell memory throughout histones and their post-translational modifications. In highly specialized cells, like sperm, the genome is mostly organized by protamines, yet a significant portion of it remains organized by histones. This protamine-histone-DNA organization, known as sperm epigenome, is established during spermiogenesis. Specific histones and their posttranslational modifications are retained at specific genomic sites and during embryo development these sites recapitulate their histone profile that harbored in the sperm nucleus. It is known that histones are the conduit of epigenetic memory from cell to cell, hence histones in the sperm epigenome may have a role in transmitting epigenetic memory from the sperm to the embryo. However, the exact function and mechanism of histone retention remains elusive. During spermatogenesis, most of the histones that organize the genome are replaced by protamines and their retention at specific regions may be deeply intertwined with the eviction and replacement mechanism. In this review we will cover some relevant aspects of histone replacement that in turn may help us to contextualize histone retention. In the end, we focus on the architectonical protein CTCF that is, so far, the only factor that has been directly linked to the histone retention process.

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“…Environmental cues (e.g., food, xenobiotics, stress, etc.) can regulate phenotypic diversity in the same genome and can influence the inheritance of epigenetic marks [10][11][12][13][14]. During this window of epigenetic plasticity, fetal growth, organ maturation and susceptibility to disease are all programmed.…”

Section: Epigenetic Programming During the First 1000 Days Of Lifementioning

confidence: 99%

Nutri-Epigenetics and Gut Microbiota: How Birth Care, Bonding and Breastfeeding Can Influence and Be Influenced?

Gabbianelli

Bordoni

Morano

et al. 2020

IJMS

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Maternal lifestyle is an important factor in the programming of an infant’s epigenome, in particular when considered alongside the mode of birth and choice of feeding method (i.e., breastfeeding or formula feeding). Beginning in utero, and during the first two years of an infant’s life, cells acquire an epigenetic memory of the neonatal exposome which can be influential across the entire lifespan. Parental lifestyle (e.g., malnutrition, alcohol intake, smoke, stress, exposure to xenobiotics and/or drugs) can modify both the maternal and paternal epigenome, leading to epigenetic inheritance in their offspring. This review aims to outline the origin of early life modulation of the epigenome, and to share this fundamental concept with all the health care professionals involved in the development and provision of care during childbirth in order to inform future parents and clinicians of the importance of the this process and the key role it plays in the programming of a child’s health.

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Epigenetic Transgenerational Inheritance

Cited by 17 publications

References 112 publications

Epigenetics of Male Infertility: The Role of DNA Methylation

Epigenetics of Male Infertility: The Role of DNA Methylation

The Interplay Between Replacement and Retention of Histones in the Sperm Genome

Nutri-Epigenetics and Gut Microbiota: How Birth Care, Bonding and Breastfeeding Can Influence and Be Influenced?

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