Epigenetics and autoimmunity

Brooks, Wesley H.; Dantec, Christelle Le; Pers, Jacques‐Olivier; Youinou, Pierre; Renaudineau, Yves

doi:10.1016/j.jaut.2009.12.006

Cited by 267 publications

(185 citation statements)

References 163 publications

(144 reference statements)

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“…For example, alterations in gene expression impacted through epigenetic mechanisms can lead to the development of autoreactive lymphocytes in systemic lupus erythematosus, synoviocyte proliferation in rheumatoid arthritis or neural demyelination in multiple sclerosis (reviewed in ref. 28). Studies in asthma are also leading to a new understanding of the role of environmental exposures in altering DNA methylation as well as histone modifications (reviewed in ref.…”

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confidence: 99%

DNA methylation in white blood cells

et al. 2011

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DNA methylation in white blood cells

et al. 2011

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“…cellular mechanisms, and have been identified as key players in producing rapid adaptation to changing environmental conditions [7,8]. Interestingly, several recent studies have established a link between cellular microenvironment and specific miRNAs [911], indicating that miRNAs may be a key to understand not only the adaptive responses of the cells to their microenvironment, but also the mechanisms underlying disease processes induced by adverse stimuli, such as hypoxia in cancer.…”

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confidence: 99%

Ion channels/transporters as epigenetic regulators? —a microRNA perspective

Jiang

Zhang

Chan

2012

Sci. China Life Sci.

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MicroRNA (miRNA) alterations in response to changes in an extracellular microenvironment have been observed and considered as one of the major mechanisms for epigenetic modifications of the cell. While enormous efforts have been made in the understanding of the role of miRNAs in regulating cellular responses to the microenvironment, the mechanistic insight into how extracellular signals can be transduced into miRNA alterations in cells is still lacking. Interestingly, recent studies have shown that ion channels/transporters, which are known to conduct or transport ions across the cell membrane, also exhibit changes in levels of expression and activities in response to changes of extracellular microenvironment. More importantly, alterations in expression and function of ion channels/transporters have been shown to result in changes in miRNAs that are known to change in response to alteration of the microenvironment. In this review, we aim to summarize the recent data demonstrating the ability of ion channels/transporters to transduce extracellular signals into miRNA changes and propose a potential link between cells and their microenvironment through ion channels/transporters. At the same time, we hope to provide new insights into epigenetic regulatory mechanisms underlying a number of physiological and pathological processes, including embryo development and cancer metastasis. ion channel, miRNAs, epigenetic, microenvironment

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“…It has been shown in both lupus and Sjogern's syndrome, two conditions characterized by the presence of ANAs and other auto-antibodies, that there are potentially pathologic epigenetic changes that are associated with auto-antibody production [36,37]. Given that epigenetic changes are implicated in the generation of autoimmunity, and that obesity has been linked to multiple epigenetic mechanisms, it is possible that nutritionally induced epigenetic changes are also driving autoimmunity in obese patients [38]. This could in fact potentially amplify whatever role, adipokines may play in autoimmunity.…”

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confidence: 99%