2023
DOI: 10.31557/apjcb.2023.8.1.75-89
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Epigenetics and Cancer: A Comprehensive Review

Abstract: Cancer is a disease with extraordinary clinical significance, with much of medical research being devoted to it. Innumerable factors are relevant in fully understanding cancer but the epigenetic aspect stands out. Epigenetics is the study of changes, often germ-line, to the genome affecting the gene expression by silencing certain genes and modifying the gene expression. The three primary mechanisms for epigenetic changes are DNA methylation, histone modification and non-coding RNA (ncRNA) associated gene sile… Show more

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Cited by 6 publications
(2 citation statements)
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“…Conversely, the silencing of tumor suppressor genes through histone deacetylation and methylation is a hallmark of many cancers. HDACs and histone demethylases can contribute to the epigenetic silencing of genes that regulate cell cycle control and DNA repair [143,201,207]. (2) Epigenetic Plasticity and Drug Resistance: Cancer cells often exhibit epigenetic plasticity, allowing them to adapt to changing environments and develop resistance to therapies [208].…”
Section: Microrna-mediated Regulation Of Histone Modificationsmentioning
confidence: 99%
“…Conversely, the silencing of tumor suppressor genes through histone deacetylation and methylation is a hallmark of many cancers. HDACs and histone demethylases can contribute to the epigenetic silencing of genes that regulate cell cycle control and DNA repair [143,201,207]. (2) Epigenetic Plasticity and Drug Resistance: Cancer cells often exhibit epigenetic plasticity, allowing them to adapt to changing environments and develop resistance to therapies [208].…”
Section: Microrna-mediated Regulation Of Histone Modificationsmentioning
confidence: 99%
“…Targeted mAbs directed against antigens unique to or overexpressed by tumor cells can induce tumor cell death through various mechanisms, with the blockade of growth factor receptor signaling being a prominent mechanism. 101 Examples of monoclonal antibodies used in cancer treatment include trastuzumab (Herceptin) for HER2-positive breast cancer and rituximab (Rituxan) for specific types of lymphoma. 102 Small-Molecule Inhibitors: Small-molecule inhibitors function by binding to specific target proteins and inhibiting their function.…”
Section: Targeted Therapies and Immunotherapymentioning
confidence: 99%