Epigenetics of Glioblastoma Multiforme

Abstract

Aberrations in the epigenetic machinery of the genome may results the inactivation of critical genes and the epigenetic changes are important mechanisms in the evolution of malignancies that not only contributes to tumorigenesis but may also precede genetic changes. Several epigenetic mechanisms have been observed in glioblastomas including DNA hyper-methylation of genes, histone modifications including methylation and acetylation, nucleosomal rearrangement and dysregulation of noncoding RNA expression have been shown to play a critical role in the biology of glioblastomas and to contribute to the clinical outcome. This review examines the general role of epigenetic changes in the malignant process and focuses on the known epigenetic changes and development of new therapeutic strategies against these malignancies.

Dichotomy in Growth and Invasion From Low to High Grade Glioma Cellular Variants 

“…al., 2011;Caffo et. al., 2014;Rasime 2015;Ghosh et al, 2017]. Present study showed high increase of methylation pattern in glioma tissue of higher grades with clustered enhanced DNMT1 expression at protein levels which has also been re ected in mRNA production level, but here the difference is less (Fig.…”

Glia to glioma: A wrathful journey

“…IGF2, IL-8) renders "epimutational" correlation with increased invasion, therapeutic escaping and abnormal proliferative nature of glioma [86,[88][89][90] . recent findings also suggest that epigenetic alterations are somehow linked to somatic gene abnormalities [87] .…”

“…SOCS1, SOCS2) and silencing genes associated with DNA repair mechanism (e.g. MGMT) [84][85][86][87] . Interestingly on the other hand, hypomethylation-oriented up-regulation of genes causing invasiveness (e.g.…”