Epigenetics of Mediterranean Diet: Altering Disease Risk

Ross, Sharon A.

doi:10.1007/978-3-319-27969-5_15

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…High intake of vegetables and fruits is associated with a lower prevalence of global DNA hypomethylation, which is linked to increased risk of cancer. 76 Conversely, increased DNA methylation of tumor suppressor genes is a risk factor in tumorigenesis. For example, our group reported that in-utero exposure to the grape phytoalexin resveratrol may prevent in rodent female offspring DNA hypermethylation and transcriptional repression of the breast cancer susceptibility gene, BRCA-1 by compounds that activate the aromatic hydrocarbon receptor (AhR).…”

Section: Prevention Of Chronic Diseasesmentioning

confidence: 99%

Mediterranean Diet and Prevention of Chronic Diseases

2017

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A large body of research data suggests that traditional dietary habits and lifestyle unique to the Mediterranean region (Mediterranean diet, MD) lower the incidence of chronic diseases and improve longevity. These data contrast with troubling statistics in the United States and other high income countries pointing to an increase in the incidence of chronic diseases and the projected explosion in cost of medical care associated with an aging population. In 2013, the MD was inscribed by UNESCO in the “Representative List of the Intangible Cultural Heritage of Humanity.” The 2015–2020 Dietary Guidelines for Americans included the MD as a healthy dietary pattern. Therefore, specific objectives of this article are to provide an overview of the nutritional basis of this healthful diet, its metabolic benefits, and its role in multiple aspects of disease prevention and healthy aging. Whereas recommendations about the MD often focus on specific foods or bioactive compounds, we suggest that the eating pattern as a whole likely contributes to the health promoting effects of the MD.

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Section: Prevention Of Chronic Diseasesmentioning

confidence: 99%

Mediterranean Diet and Prevention of Chronic Diseases

2017

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“…This whole-diet approach has been described as the most optimal preventive approach and is based on the synergistic interaction between several nutrients, as suggested by findings from the Three City observational study [ 22 ]. The Mediterranean diet and its correlates, like the MIND diet, characterized by a high intake of whole cereals and legumes, fruits, vegetables, and fish, are among the best described diets, with shown protective effects among several populations [ 36 , 37 , 38 , 39 , 40 , 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Mediterranean Dietary Pattern on Cognitive Status in Community-Dwelling Older Adults

Yaghi,

El Hayeck,

Boulos

et al. 2023

Nutrients

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Modifiable factors associated with cognitive decline (CD) require more attention, particularly dietary patterns. This study aimed to investigate the link between cognitive decline and associated factors, particularly dietary patterns (DPs), in community-dwelling older Lebanese of modest economic status. Our cross-sectional national study included 352 participants above 60 years old, from the medico-social centers of the ministry of social affairs all over the country. CD was screened based on literacy. Nutritional and dietary data were collected through a validated food frequency questionnaire. DPs were extracted by the K-mean cluster analysis. CD was found in 32.7% and 61.5% of literate and illiterate groups, respectively. Identified DPs included a Westernized type and Mediterranean type, with high and moderate food intakes. In the context of literacy, independent factors associated with CD were age above 80 years, living in Beirut, frailty, and adopting a Westernized (OR = 3.08, 95% CI: 1.22–7.8) and a high-intake Mediterranean DP (OR = 2.11, 95% CI: 1.05–4.22). In the context of illiteracy, the same factors were associated with CD, but not DP nor frailty, with an age cut-off at 78 years. In a Lebanese sample of older adults, factors associated with CD depend on the level of literacy, with DP only associated with CD in the context of literacy.

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Nutritional genomics, inflammation and obesity

Corrêa¹,

Quintanilha²,

Norde³

et al. 2020

Archives of Endocrinology and Metabolism

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The Human Genome Project has significantly broadened our understanding of the molecular aspects regulating the homeostasis and the pathophysiology of different clinical conditions. Consequently, the field of nutrition has been strongly influenced by such improvements in knowledge -especially for determining how nutrients act at the molecular level in different conditions, such as obesity, type 2 diabetes, cardiovascular disease, and cancer. In this manner, characterizing how the genome influences the diet and vice-versa provides insights about the molecular mechanisms involved in chronic inflammation-related diseases. Therefore, the present review aims to discuss the potential application of Nutritional Genomics to modulate obesity-related inflammatory responses. Arch

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Epigenetics of Mediterranean Diet: Altering Disease Risk

Cited by 3 publications

References 61 publications

Mediterranean Diet and Prevention of Chronic Diseases

Mediterranean Diet and Prevention of Chronic Diseases

Effect of Mediterranean Dietary Pattern on Cognitive Status in Community-Dwelling Older Adults

Nutritional genomics, inflammation and obesity

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