Epilepsy and neurodevelopmental disorders of language

Pal, Deb K.

doi:10.1097/wco.0b013e328344634a

Cited by 37 publications

(27 citation statements)

References 38 publications

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“…This seems to contradict our finding that the earlier age of disease onset is associated with more severe language deficit in BECTS children. Functional MRI studies have shown abnormality in functional connectivity and language impairment in BECTS patients [26,27,28,29]. Since epileptic discharges in sleep may interfere with the development of cognitive linguistic processes [8], it is likely that early onset of epileptic discharges, especially during the crucial period of language development, contributes to the severe language deficit in BECTS children.…”

Section: Discussionmentioning

confidence: 99%

Language Dysfunction Is Associated with Age of Onset of Benign Epilepsy with Centrotemporal Spikes in Children

Ma¹,

Chen²,

Wang³

et al. 2015

Eur Neurol

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Aims: To assess the language function of children with benign epilepsy with centrotemporal spikes (BECTS), and investigate associated risk factors. Methods: The language function of 63 children with BECTS and 30 healthy controls was assessed using the language subtest of the Chinese version of the Wechsler Intelligence Scale for Children (C-WISC). Multiple linear regression analysis was applied to assess the risk factors of language dysfunction in children with BECTS. Results: The total score of language test of C-WISC, and the individual scores, were significantly lower in children with BECTS compared with the scores attained by the healthy controls, and were also significantly lower in children with BECTS with onset earlier than 6 years of age compared with those whose disease onset occurred later. There were no significant correlations between language function and treatment, frequency of seizures, lateralization of centrotemporal spikes, or duration of seizures, but there was a positive correlation between language dysfunction and the age at disease onset. Conclusion: Children with BECTS have language difficulties, especially those with earlier disease onset. Early age at seizure onset is a risk factor for language dysfunction in children with BECTS.

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Section: Discussionmentioning

confidence: 99%

Language Dysfunction Is Associated with Age of Onset of Benign Epilepsy with Centrotemporal Spikes in Children

Ma¹,

Chen²,

Wang³

et al. 2015

Eur Neurol

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“…Studies often report that the mean IQ of groups with epilepsy is at the lower end of the normal range [23,24], and the ability to reason about belief states and to understand the causes and consequences of emotions is impaired in children with global developmental delay [25,26]. Children with epilepsy with normal global cognition are also at higher risk for disorders of language and communication [27][28][29]. Preschool CWE have been found to have lower verbal IQ and deficits in basic language functions [30][31][32], whereas school-aged CWE cohorts have displayed additional problems with more complex skills that include pragmatic language [33,34] and conversational discourse functions [28,35].…”

Section: Introductionmentioning

confidence: 99%

Impaired performance on advanced Theory of Mind tasks in children with epilepsy is related to poor communication and increased attention problems

Lunn

Lewis

Sherlock

2015

Epilepsy & Behavior

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Children with epilepsy (CWE) have social difficulties that can persist into adulthood, and this could be related to problems with understanding others' thoughts, feelings, and intentions. This study assessed children's ability to interpret and reason on mental and emotional states (Theory of Mind) and examined the relationships between task scores and reports of communication and behavior. Performance of 56 CWE (8-16years of age) with below average IQ (n=17) or an average IQ (n=39) was compared with that of 62 healthy controls with an average IQ (6-16years of age) on cognition, language, and two advanced Theory of Mind (ToM) tasks that required children to attribute mental or emotional states to eye regions and to reason on internal mental states in order to explain behavior. The CWE-below average group were significantly poorer in both ToM tasks compared with controls. The CWE - average group showed a significantly poorer ability to reason on mental states in order to explain behavior, a difference that remained after accounting for lower IQ and language deficits. Poor ToM skills were related to increased communication and attention problems in both CWE groups. There is a risk for atypical social understanding in CWE, even for children with average cognitive function.

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“…Those syndromes may sometimes overlap with each other [7,8]. They may also show broader connections; hence, RE may be associated with developmental verbal dyspraxia (DVD) [9,10,11], i.e. difficulties in mastering sequences of oral and facial movements, impairing speech articulation, and accompanied by additional problems with expressive and receptive language.…”

Section: Introductionmentioning

confidence: 99%

The Role of the Urokinase Receptor in Epilepsy, in Disorders of Language, Cognition, Communication and Behavior, and in the Central Nervous System

Bruneau¹,

Szepetowski²

2011

CPD

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As a key component of the plasminogen activation system, uPAR, the receptor for the plasminogen activator of the urokinase type, is involved in many physiological and pathological processes. Besides its classical roles, there has been increased evidence that uPAR or uPAR-associated pathways, participate in the development, in the functioning and in the pathology of the central nervous system. Qualitative and quantitative changes in the expressions of uPAR and of its canonical ligand uPA have been observed in a large variety of epileptic disorders, either in human or in animal models, as well as in other brain diseases (stroke and brain trauma, multiple sclerosis, Alzheimer's disease, cerebral malaria, HIV-associated leukoencephalopathy and encephalitis). The variety of such pathological conditions and the different brain areas and cell types involved, likely reflects the wide range and the complexity of the multiple and somehow intertwined pathophysiological mechanisms related with uPAR. In the mouse, the knock-out of the Upar-encoding gene (Plaur) leads to significant and nearly complete loss in parvalbumin-containing interneurons during brain development. This is associated with increased susceptibility to spontaneous and chemically-induced seizures and with increased anxiety and impaired social interactions. The recent identification of the novel uPAR ligand SRPX2 (Sushi repeat protein, X-linked 2) and the regulation of both the SRPX2 and PLAUR genes by transcription factor FOXP2 has shed novel and exciting insights into the role of uPAR-related molecular networks in rolandic epilepsy, in developmental verbal dyspraxia, in perisylvian polymicrogyria, and generally in disorders of the speech areas and circuits. uPAR, its regulators and partners, as well as other proteins containing Ly-6/uPAR/alpha-neurotoxin domains, represent key entry points for present and future studies not only on speech-related disorders but also on epilepsy and autism spectrum disorders.

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Epilepsy and neurodevelopmental disorders of language

Cited by 37 publications

References 38 publications

Language Dysfunction Is Associated with Age of Onset of Benign Epilepsy with Centrotemporal Spikes in Children

Language Dysfunction Is Associated with Age of Onset of Benign Epilepsy with Centrotemporal Spikes in Children

Impaired performance on advanced Theory of Mind tasks in children with epilepsy is related to poor communication and increased attention problems

The Role of the Urokinase Receptor in Epilepsy, in Disorders of Language, Cognition, Communication and Behavior, and in the Central Nervous System

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