Epilepsy in the elderly

Leppik, Ilo E.

doi:10.1007/s11910-001-0096-5

Cited by 15 publications

(44 citation statements)

References 28 publications

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“…As was mentioned above, we found that this vitamin demonstrated a protective effect against seizure-related disorders of the BBB permeability in young and adult rats, and the 70 mg/kg dose was effective [12]. At the same time, it is well-known that there are noticeable age-dependent modifications of the epileptic and epileptiform activity [27]. The threshold value for the attacks created by PTZ introductions is higher in old animals, durations of generalized attacks are longer in this age group than in adults, and old animals are distinguished by a higher relapse ratio [28,29].…”

Section: Discussionsupporting

confidence: 57%

Effect of Vitamin E on Blood-Brain Barrier Permeability in Aged Rats with PTZ-Induced Convulsions

2011

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The effect of vitamin E on the blood-brain barrier (BBB) permeability was studied under conditions of pentylenetetrazole (PTZ)-induced convulsions in aged (23-to 24-month-old) male albino rats; Evans Blue was used as a tracer. The BBB permeability was found to considerably increase in rats with PTZ-evoked seizures; the Evans Blue contents in the left and right hemispheres and cerebellum + brainstem region were significantly higher than those in the control. Vitamin E used in the dose of 70 mg/kg exerted practically no beneficial effect on the increased BBB permeability in rats with seizures, while a greater dose of vitamin E (700 mg/kg) exerted a significant protective effect, especially with respect to the cerebellum + brainstem regions (P < 0.01). The seizure-related rise in the arterial blood pressure was also smaller in the latter experimental group. Thus, our observations confirm the importance of the dose of vitamin E as a protective factor for the BBB permeability and demonstrate that the dose dependence of this antioxidant in aged animals differs from that in younger organisms.

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Section: Discussionsupporting

confidence: 57%

Effect of Vitamin E on Blood-Brain Barrier Permeability in Aged Rats with PTZ-Induced Convulsions

2011

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“…The elderly are fastest growing segment of the population 1 . In many developed countries, they constitute approximately 30% of the total population 2 .…”

Section: Introductionmentioning

confidence: 99%

Caracterização da epilepsia com início após os 60 anos de idade

Bruscky

Leite

Correia

et al. 2016

Rev. bras. geriatr. gerontol.

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Introduction: Despite its high incidence, the characteristics of epilepsy in elderly patients have not yet been widely studied. The clinical presentation of the disease is mostly atypical and findings from complementary examinations provide little help with diagnosis. Few reports have characterized this group of individuals. Objective: To describe the characteristics of patients with epilepsy with onset after 60 years of age. Method: A descriptive study of a case series was designed. For this purpose, 50 patients diagnosed with epilepsy with onset after 60 years of age, treated at the outpatient epilepsy clinic of the Hospital da Restauração (Recife-PE), were consecutively assessed. Results: The 50 patients included in the study had an average age of 75.3 (±13) years, 30 (60.0%) were female and 20 (40.0%) were male. The average age at the first seizure episode was 72.5 (±11.5) years. Focal epilepsy seizures were the most predominant (83.8%). The occurrence of status epilepticus was low in this group (4.0%). Symptomatic epilepsy was the most frequent type, and most of the causes were of vascular etiology (43.0%). Carbamazepine was most commonly used for treatment, and the patients responded well to low-dose monotherapy. Electroencephalograms displayed normal results in many cases (50.0%), and neuroimaging showed nonspecific findings for most individuals (83.0%). Conclusion: Epilepsy in elderly patients is predominantly focal and symptomatic, with a low occurrence of status epilepticus and good therapeutic response. The encephalogram and neuroimaging results are frequently nonspecific.

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“…Yaşlılarda aktif epilepsi prevalansı %1.5 olup, bu değer genç erişkinlerin üç katına eşittir. [1,2] Fakat huzurevlerinde kalanlar arasında bu değer %5'i aşmaktadır. [1,2] Yaşlılardaki epilepsi genç bireylerle aynı özellikleri göstermez.…”

Section: Introductionunclassified

Epilepsy in elderly patients

Halaç¹

2015

Epilepsi

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SummaryObjectives: The incidence of new-onset epilepsy is high among the elderly. This study presents the demographic characteristics, etiological factors, seizure types and response rates to treatment in a group of patients aged 65 years or over with delayed-onset epilepsy. Methods:The study comprised a retrospective evaluation of the records of 43 patients aged 65 or older with a diagnosis of delayed-onset epilepsy who were admitted to the epilepsy clinic in the Neurology Department of Bezmialem University Faculty of Medicine.Results: Patient mean age was 74.9 (66-92 years). Underlying disease was found to be cerebrovascular disease in 37.2%. Based on seizure type, 67.4% (n=29) patients had partial-onset and 32.6% (n=14) had generalized seizure. Treatment protocol in 93% (n=40) of the patients was monotherapy antiepileptic drugs, the most commonly used being levetiracetam (53.5%). Assessment of drug side effects showed no complaint in 86% (n=37) of the patients. During the three months prior to the study, 95.3% of the patients had been seizure free. Conclusion:The study found cerebrovascular disease to be the most common etiological factor in delayed-onset epilepsy. Partial-onset secondary generalized seizure was the most common seizure type. All patients responded well to monotherapy and have a good prognosis.Key words: Epilepsy; treatment; elderly patients. ÖzetAmaç: Yaşlılarda yeni başlangıçlı epilepsi insidansı oldukça yüksektir. Çalışmada, 65 yaş üstü geç başlangıçlı epilepsi tanısı alan hastaların demografik özellikleri, etiyolojik faktörleri, nöbet tipleri ve tedaviye yanıt oranları sunulmuştur ve literatür eşliğinde sonuçlar tartışılmıştır. Sonuç: Geç başlangıçlı epilepsi hastalarında en sık görülen etiyolojik neden serebrovasküler hastalık olup nöbet tipi çoğunlukla parsiyel başlangıçlı sekonder jeneralize tonik kloniktir, hastalar monoterapiye iyi yanıt verir ve prognoz iyi seyirlidir. Gereç ve

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Epilepsy in the elderly

Cited by 15 publications

References 28 publications

Effect of Vitamin E on Blood-Brain Barrier Permeability in Aged Rats with PTZ-Induced Convulsions

Effect of Vitamin E on Blood-Brain Barrier Permeability in Aged Rats with PTZ-Induced Convulsions

Caracterização da epilepsia com início após os 60 anos de idade

Epilepsy in elderly patients

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