Epileptic Prodromal Alzheimer’s Disease, a Retrospective Study of 13 New Cases: Expanding the Spectrum of Alzheimer’s Disease to an Epileptic Variant?

Crétin, Benjamin; Sellal, François; Philippi, Nathalie; Bousiges, Olivier; Bitonto, Laure Di; Milch, Catherine; Blanc‬, ‪Frederic

doi:10.3233/jad-150096

Cited by 103 publications

(87 citation statements)

References 14 publications

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“…Studies have shown that seizures related to AD may precede or coincide with the onset of the cognitive decline (3–5). Our three cases suggest that elderly onset temporal epileptic auras may be a presenting symptom of AD.…”

Section: Discussionmentioning

confidence: 99%

“…Seizures are prevalent in around 28% of cases with AD and were long thought mostly to be a late manifestation of the disease process with the progression of neurodegeneration (2). However, more recent studies have revealed that in some cases, seizures related to AD may precede or coincide with the onset of the cognitive changes (3–5). Neuroimaging studies in patients with mild cognitive impairment (MCI) have highlighted hippocampal hyperactivation on fMRI (6), and treatment with the anti-seizure medication levetiracetam targeting this hyperactivation was found to improve memory task performance (7).…”

Section: Introductionmentioning

confidence: 99%

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Recurrent Epileptic Auras As a Presenting Symptom of Alzheimer’s Disease

et al. 2017

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Seizures are a common co-morbidity during the course of Alzheimer’s disease (AD) and in a subset of patients may be one of the presenting symptoms. In this case series, we highlight three patients with recurrent medically refractory epileptic auras whose work up ultimately lead to the diagnosis of AD. All three patients underwent prolonged EEG, serial neuropsychological testing, FDG-PET, cerebrospinal fluid (CSF) AD biomarkers, and MRI. CSF biomarkers were particularly helpful in two cases. These cases highlight the importance of having a high index of suspicion for AD in new onset “idiopathic” epilepsy in the elderly.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recurrent Epileptic Auras As a Presenting Symptom of Alzheimer’s Disease

et al. 2017

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“…Moreover, disturbed activity may contribute to the development of cognitive violations: epileptiform and rhythmic abnormalities in the temporal regions (in particular in the hippocampus) can cause amnestic disorders, which were reduced by antiepileptic drug treatment (Gallassi, 2006; Bakker et al, 2012). In patients with seizures in combination with AD, a case series from California with so called “vu/déjà vu” phenomena was described (Vossel et al, 2013), while another series from France (Cretin et al, 2016) had some cases that were termed “epileptic prodromal AD.” The authors believed that there is an epileptic version of AD, which usually starts with seizures as an initial symptom followed by cognitive deficit. Similar signs of cognitive and behavioral impairments in TLE and AD have been recently described by Chin and Scharfman (2013).…”

Section: Electro-clinical Data For Patients With “Epileptic Prodromalmentioning

confidence: 99%

“…Adult-onset epilepsy of unknown cause could thus represent a risk factor for the ongoing neurodegenerative damage, even when epileptic manifestations and clinically recognized dementia are separated by long time (Cretin et al, 2016; Sarkis et al, 2017). …”

Section: Electro-clinical Data For Patients With “Epileptic Prodromalmentioning

confidence: 99%

Alterations of Coherent Theta and Gamma Network Oscillations as an Early Biomarker of Temporal Lobe Epilepsy and Alzheimer’s Disease

Kitchigina

2018

Front. Integr. Neurosci.

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Alzheimer’s disease (AD) and temporal lobe epilepsy (TLE) are the most common forms of neurodegenerative disorders characterized by the loss of cells and progressive irreversible alteration of cognitive functions, such as attention and memory. AD may be an important cause of epilepsy in the elderly. Early diagnosis of diseases is very important for their successful treatment. Many efforts have been done for defining new biomarkers of these diseases. Significant advances have been made in the searching of some AD and TLE reliable biomarkers, including cerebrospinal fluid and plasma measurements and glucose positron emission tomography. However, there is a great need for the biomarkers that would reflect changes of brain activity within few milliseconds to obtain information about cognitive disturbances. Successful early detection of AD and TLE requires specific biomarkers capable of distinguishing individuals with the progressing disease from ones with other pathologies that affect cognition. In this article, we review recent evidence suggesting that magnetoencephalographic recordings and coherent analysis coupled with behavioral evaluation can be a promising approach to an early detection of AD and TLE.Highlights Data reviewed include the results of clinical and experimental studies.Theta and gamma rhythms are disturbed in epilepsy and AD.Common and different behavioral and oscillatory features of pathologies are compared.Coherent analysis can be useful for an early diagnostics of diseases.

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“…AD patients, including those with familial AD, are at increased risk for epileptic seizures, and recent findings suggest a very high incidence of sub-clinical epileptiform activity in AD (Born, 2015). Data from longitudinal human studies suggest that neuronal hyperexcitability occurs before cognitive impairment (Cretin et al, 2016). Early cell culture studies demonstrated that pathogenic forms of Aβ (Mattson et al, 1992) and tau (Furukawa et al, 2003) perturb neuronal calcium homeostasis, which can render neurons vulnerable to excitotoxicity, while subsequent studies showed that neurons in transgenic mice that express AD-causing APP, presenilin 1, or tau mutations exhibit vulnerability to excitotoxicity (Decker et al, 2016; Guo et al,1999; Hall et al, 2015; Palop et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Brain regional synchronous activity predicts tauopathy in 3×TgAD mice

Liu

Stein

et al. 2018

Neurobiology of Aging

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Alzheimer’s disease (AD) is characterized by progressive cognitive impairment and by extensive neuronal loss associated with extracellular amyloid β-peptide (Aβ) plaques and intraneuronal tau pathology in temporal and parietal lobes. AD patients are at increased risk for epileptic seizures, and data from experimental models of AD suggest that aberrant neuronal network activity occurs early in the disease process before cognitive deficits and neuronal degeneration. The contributions of Aβ and/or tau pathologies to dysregulation of neuronal network activity are unclear. Using a transgenic mouse model of AD (3 × TgAD mice) in which there occurs differential age-dependent development of tau and Aβ plaque pathologies, we applied analysis of resting state functional magnetic resonance imaging regional homogeneity, a measure of local synchronous activity, to discriminate the effects of Aβ and tau on neuronal network activity throughout the brain. Compared to age-matched wild-type mice, 6- to 8-month-old 3 × TgAD mice exhibited increased regional homogeneity in the hippocampus and parietal and temporal cortices, regions with tau pathology but not Aβ pathology at this age. By 18–24 months of age, 3 × TgAD mice exhibited extensive tau and Aβ pathologies involving the hippocampus and multiple functionally related brain regions, with a spatial expansion of increased local synchronous activity to include those regions. Our findings demonstrate that age-related brain regional hypersynchronous activity is associated with early tau pathology in a mouse model, consistent with a role for early tau pathology in the neuronal circuit hyperexcitability that is believed to precede and contribute to neuronal degeneration in AD.

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Epileptic Prodromal Alzheimer’s Disease, a Retrospective Study of 13 New Cases: Expanding the Spectrum of Alzheimer’s Disease to an Epileptic Variant?

Cited by 103 publications

References 14 publications

Recurrent Epileptic Auras As a Presenting Symptom of Alzheimer’s Disease

Recurrent Epileptic Auras As a Presenting Symptom of Alzheimer’s Disease

Alterations of Coherent Theta and Gamma Network Oscillations as an Early Biomarker of Temporal Lobe Epilepsy and Alzheimer’s Disease

Brain regional synchronous activity predicts tauopathy in 3×TgAD mice

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