Epileptic Seizures Associated With Cisplatin Administration

Mead, GM; Arnold, A.; Green, J.A.; Macbeth, Fergus; Williams, Carmen J.; Whitehouse, J. M. A.

doi:10.1016/s0022-5347(17)51194-5

Cited by 25 publications

(18 citation statements)

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“…Mead et al (12) described eight patients who experienced epileptic seizures while undergoing chemotherapy with agents containing CDDP. Severe hyponatremia, perhaps related to SIADH, was identified in two of these patients as a possible precipitating factor.…”

Section: Case Reportmentioning

confidence: 99%

Syndrome of Inappropriate Secretion of ADH (SIADH) Following Cisplatin Administration in a Pulmonary Adenocarcinoma Patient with a Malignant Pleural Effusion.

et al. 2001

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Wereport a patient with pulmonary adenocarcinoma complicated by the syndromeof inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS). A 66-year-old womanwas diagnosed as having pulmonary adenocarcinoma with malignant pleural effusion following investigations for cough and dyspnea. After drainage of the effusion she received combination chemotherapy with CDDPand VDS. She developed SIADH 48 hours following chemotherapy. Interestingly, the use of carboplatin (CBDCA) and VDSin the subsequent treatment course was well tolerated indicating that the SIADHwas most likely to have been induced by administration of CDDP.

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Section: Case Reportmentioning

confidence: 99%

Syndrome of Inappropriate Secretion of ADH (SIADH) Following Cisplatin Administration in a Pulmonary Adenocarcinoma Patient with a Malignant Pleural Effusion.

et al. 2001

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“…Other possible causes for epileptic seizures such as septic processes, mass lesions and vascular insult have also to be ruled out [9]. As seizures after cisplatin administration mostly occur only once and due to the fact that the neurotoxic side effects disappear with time, this clinical situation does not constitute an indication for long term antiepileptic therapy [11]. Furthermore, they do not represent a contraindication for further cytostatic therapy if there are no other clinical objections [11,12].…”

Section: Discussionmentioning

confidence: 99%

“…As seizures after cisplatin administration mostly occur only once and due to the fact that the neurotoxic side effects disappear with time, this clinical situation does not constitute an indication for long term antiepileptic therapy [11]. Furthermore, they do not represent a contraindication for further cytostatic therapy if there are no other clinical objections [11,12]. Nevertheless, further studies are neces sary to decide which is the best management of patients suffering from cisplatin-induced seizures.…”

Section: Discussionmentioning

confidence: 99%

“…They commonly are manifested by sensory peripheral neuropathy which occasionally progresses to motor involvement [5,6,11,12], Experimental data by Cowan et al [4] indicate an upward tendency of subclinical nerve damage with increasing cisplatin dose. Serial nerve conduction stud ies were performed on cancer patients treated with cisplatin doses ranging from 200 to 300 mg/m2.…”

Section: Discussionmentioning

confidence: 99%

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Seizures Associated with Cisplatin Administration

Brauers

Mattelaer²,

Mersdorf³

et al. 1997

Eur Urol

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“…Neurological and hematological complications similar to those that can occur in TTP, including seizures [15,16], cortical blindness [15], as well as Coombs' positive hemolytic anemia [17], have also been reported in a small num ber of patients receiving chemotherapy with cisplatin alone or in combination with other agents. We observ ed a patient who received cisplatin and bleomycin, and then developed a complication with clinical similari ties to HUS.…”

Section: Introductionmentioning

confidence: 95%

Elevated Plasma von Willebrand Factor Levels and Arterial Occlusive Complications Associated with Cisplatin-Based Chemotherapy

et al. 1985

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Factor-VIII-related von Willebrand factor (vWF) multimers are synthesized by endothelial cells, and plasma vWF antigen levels are elevated in some disorders associated with endothelial cell perturbation. We studied 13 patients during cisplatin-basedcombination chemotherapy for squamous cell carcinoma of the head and neck, esophagus, or lung. Before therapy, 3 of the patients had vWF antigen levels that were ≥400% of normal; and further elevations occurred during chemotherapy. Two of these patients had cerebrovascular accidents, and the third had complications similar to the hemolytic-uremic and acute respiratory distress syndromes. No abnormalities in plasma vWF patterns were detected. Elevated plasma vWF antigen levels before therapy may identify a subgroup of patients at special risk for arterial occlusive complications following cisplatin-based chemotherapy.

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Epileptic Seizures Associated With Cisplatin Administration

Cited by 25 publications

References 0 publications

Syndrome of Inappropriate Secretion of ADH (SIADH) Following Cisplatin Administration in a Pulmonary Adenocarcinoma Patient with a Malignant Pleural Effusion.

Syndrome of Inappropriate Secretion of ADH (SIADH) Following Cisplatin Administration in a Pulmonary Adenocarcinoma Patient with a Malignant Pleural Effusion.

Seizures Associated with Cisplatin Administration

Elevated Plasma von Willebrand Factor Levels and Arterial Occlusive Complications Associated with Cisplatin-Based Chemotherapy

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