2006
DOI: 10.1016/j.hepres.2005.12.011
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Epimorphin expression and stellate cell status in mouse liver injury

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Cited by 19 publications
(23 citation statements)
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“…[11][12][13] Epimorphin is reported to bind aVb5 and aVb1 integrins on target epithelial cells and to initiate specific signaling processes, 32 but its receptors and its signaling pathways have not been fully identified and its functions in vivo remain unclear.…”
Section: Discussionmentioning
confidence: 99%
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“…[11][12][13] Epimorphin is reported to bind aVb5 and aVb1 integrins on target epithelial cells and to initiate specific signaling processes, 32 but its receptors and its signaling pathways have not been fully identified and its functions in vivo remain unclear.…”
Section: Discussionmentioning
confidence: 99%
“…Nevertheless, our finding that epimorphin inhibition caused persistently increased macrophage and myofibroblast infiltration, cell proliferation and loss of E-cadherin expression on tubular epithelial cells strongly suggests that epimorphin functions basically in the repair of renal fibrosis possibly through mesenchymal-epithelial interaction. Considering what we know of tissue damage in other organs, [11][12][13][14][15] we assume that when a kidney is injured epimorphin functions as a repair protein and has a role similar to its role as a morphogen when a kidney develops.…”
Section: Discussionmentioning
confidence: 99%
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“…The protein is known to act as a morphogen during tissue restoration in the adult liver (Yoshino et al 2006).…”
Section: Discussionmentioning
confidence: 99%
“…Deletion analyses of epimorphin have revealed that the morphogenic and vesicle-fusion functions are separable: the the C-terminal SNARE and TM domains are essential for syntaxin-mediated vesicular fusion (Chen and Scheller, 2001;Giraudo et al, 2006) but they are dispensable for epimorphinmediated morphogenic activity . Despite these differences and the many studies in a diverse range of tissues in which extracellularly presented epimorphin has been shown to regulate developmental processes (Bascom et al, 2005;Fritsch et al, 2002;Hirai et al, 1998;Hirai et al, 2001;Hirai et al, 1992;Lehnert et al, 2001;Oka and Hirai, 1996;Oka et al, 2006;Qin et al, 2005;Radisky et al, 2003;Takebe et al, 2003;Tulachan et al, 2006;Yoshino et al, 2006), the Epimorphin (also known as syntaxin 2) acts as an epithelial morphogen when secreted by stromal cells of the mammary gland, lung, liver, colon, pancreas and other tissues, but the same molecule functions within the cell to mediate membrane fusion. How this molecule, which lacks a signal sequence and contains a transmembrane domain at the Cterminus, translocates across the plasma membrane and is secreted to become a morphogen, and how it initiates morphogenic events is not clear.…”
Section: Introductionmentioning
confidence: 99%