Epinephrine Oxidation in the Presence of Interfering Molecules on Gold and Gold Electrodes modified with Gold Nanoparticles and Thiodipropionic Acid in Aqueous Solution. A Comparative Study

Abstract

Thiodipropionoc acid (TDPA), cysteamine (CA) and gold nanoparticles (Au-NPs) modified gold pure electrodes have been applied in voltammetric sensors for simultaneous detection of epinephrine (EP), ascorbic (AA) and uric (UA) acids. Modified electrodes with self assembled layers (SAMs) show high selectivity, sensitivity, reproducibility and stability. A linear relationship between the epinephrine concentration and the current response is obtained in the range of 0.1 mM to 0.65 mM with the detection limit 0.065 mM for the electrodes modified at 2D surface and in the range of 0.1 mM to 0.75 mM with the detection limit 0.082 mM for the electrodes modified at the 3D surface.

Electrochemical characterization of poly(fuchsine acid) modified glassy carbon electrode and its application for simultaneous determination of ascorbic acid, epinephrine and uric acid

“…The detection limits (S/N = 3) were determined to be 0.009, 0.01 and 0.03 μmol L −1 for AA, EP, and UA, respectively. These were much lower than those previously reported for the simultaneous detection of AA, EP, and UA [15][16][17][18][19][20][21][22][23]. The anodic peak currents of AA, EP, and UA were reduced to 97.9%, 98.7% and 97.35% of the initial responses, respectively, after 40 consecutive CV measurements in the same condition.…”

Selective Electrochemical Detection of Epinephrine Using Gold Nanoporous Film

“…The electrochemical behavior of epinephrine was reported to be influenced by the acidity or alkalinity of the solution [50]. Effect of solution pH on the electrochemical behaviors was analyzed in PBS solutions of different pH (4, 7, and 9).…”

Polymer/Iron Oxide Nanoparticle Modified Glassy Carbon Electrodes for the Enhanced Detection of Epinephrine

“…Various methods, including liquid chromatography , spectrophotometry , flow injection analysis , chemiluminescence , capillary electrophoresis , and photokinetics have been reported for the determination of epinephrine. However, since epinephrine is easily oxidized, electrochemical methods constitute a quicker, cost‐effective, simple and more sensitive alternative, and have been amongst the most appealing and suitable techniques employed . Despite the advantages, the electrochemical determination of epinephrine can be a challenging task.…”

“…Additionally, epinephrine coexists in natural environments with other electroactive species such as ascorbic acid and uric acid, which oxidize at unmodified electrodes at almost the same potential, leading to poor selectivity and reproducibility . To overcome these limitations, the use of modified electrodes for monitoring epinephrine has been proposed .…”

“…Carbon nanotube modified electrodes have also been prepared and used for EP detection, in combination with other components such as cyclodextrin , Nafion , hematoxylin , cobalt phthalocyanine , tyrosinase , dopamine dithiocarbamate , chitosan , and iron oxide nanoparticles (Fe 3 O 4 ) . Gold , ITO and graphene modified electrodes are further attempts to the fabrication of EP electrochemical sensors.…”