Epinephrine stimulates prostaglandin synthesis by bullfrog lung from warm‐acclimated, but not cold‐acclimated, animals

Herman, Ceil A.; Martinez, Jeanelle M.

doi:10.1002/jez.1402480113

Cited by 6 publications

(1 citation statement)

References 25 publications

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“…Thus ANP may function as a negative feedback regulator of ET 3 and the vasoconstrictive actions of endothelin are opposed by this vasodilator 27 . Also, prostaglandin synthesis was shown to be increased by adrenaline 28 , by which counter regulatory vasodilatation may be induced.…”

Section: Discussionmentioning

confidence: 99%

Influence of different volume therapy regimens on regulators of the circulation in the critically ill

Boldt¹,

Müeller²,

Menges³

et al. 1996

British Journal of Anaesthesia

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Various vasoactive substances are involved in the regulation of the macro- and microcirculation. We have investigated if these regulators change during long-term volume therapy with human albumin (HA) or hydroxyethylstarch solution (HES) in trauma and sepsis patients. To maintain pulmonary capillary wedge pressure (PCWP) at 10-15 mm Hg, either 20% HA (HA-trauma, n = 14; HA-sepsis, n = 14) or 10% low-molecular weight HES solution (HES-trauma, n = 14; HES-sepsis, n = 14) were infused for 5 days, otherwise patient management did not differ between the two groups (trauma/sepsis). Mean arterial pressure (MAP), heart rate (HR), PCWP and cardiac index (CI) were monitored in all patients. Liver function was assessed using the monoethylglycinexylidide (MEGX) test, and gastric intramucosal pH (pHi) was monitored by tonometry to assess splanchnic perfusion. Plasma concentrations of vasopressin, endothelin-1, adrenaline, noradrenaline, atrial natriuretic peptide and 6-keto-prostaglandin F1 alpha were measured from arterial blood samples. All measurements were carried out on the day of admission to the intensive care unit (trauma patients) or on diagnosis of sepsis, and daily over the next 5 days at 12:00. MAP, HR and PCWP did not differ between the corresponding subgroups (trauma/sepsis). Cl increased significantly more in the HES than in the HA groups. pHi and MEGX plasma concentrations did not differ in the trauma patients throughout the study. Both were lower than normal in the sepsis groups and increased more markedly in the HES than in the albumin-treated patients (P < 0.05). In the trauma patients, concentrations of all vasoactive regulators were very similar in both groups. In both sepsis groups, vasopressors (vasopressin, endothelin-1, noradrenaline and adrenaline) were significantly increased above normal at baseline and decreased more markedly in HES than in HA patients. Concentrations of atrial natriuretic peptide increased only in the HA patients (from 159 (SD 31) to 215 (38) pg ml-1 on day 2). Plasma concentrations of 6-keto-prostaglandin F1 alpha decreased significantly only in the HES sepsis patients (from 112 (25) to 47 (15) pg ml-1).

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Section: Discussionmentioning

confidence: 99%

Influence of different volume therapy regimens on regulators of the circulation in the critically ill

Boldt¹,

Müeller²,

Menges³

et al. 1996

British Journal of Anaesthesia

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Hormonal and metabolic responses of juvenile alligators to cold shock

Lance¹,

Elsey²

1999

J. Exp. Zool.

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Eicosanoid synthesis by warm‐and cold‐acclimated American bullfrog (Rana catesbeiana) brain

et al. 1994

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Previous studies in bullfrogs have demonstrated the presence of leukotriene (LT)C4 binding sites in the brain. However, synthesis of eicosanoids by brain tissue has not been examined. Because prostaglandin (PG) synthesis differs in warm- and cold-acclimated bullfrog lung tissue, this study compared the synthesis of prostaglandins and leukotrienes in brains from warm-(22 degrees C) and cold-acclimated (5 degrees C) animals. Initial experiments determined that leukotriene and prostaglandin production rates were greatest during the initial 30 min time period. Therefore, tissues were incubated in Munsick's solution and gassed with 95% O2, 5% CO2 for 30 min. Media were analyzed by radioimmunoassay for LTC4, LTB4, PGE2, PGF2 alpha, TXB2, and 6-keto PGF1 alpha. In warm-acclimated bullfrog brains, production was as follows: LTC4 > PGE2 > 6-keto PGF1 alpha, thromboxane (TX)B2, LTB4, and PGF2 alpha. Brain tissues from cold-acclimated animals incubated at 22 degrees C produced significantly greater quantities of PGE2 and 6-keto PGF1 alpha than did brains from warm-acclimated animals. Stimulation of TXB2 levels was observed when the animal was stunned with a blow to the head prior to decapitation. Indomethacin, a cyclooxygenase inhibitor, decreased prostaglandin but not leukotriene synthesis. Epinephrine (4 x 10(-8) M), the amphibian sympathetic postganglionic neurotransmitter, stimulated leukotriene synthesis by brains from warm-acclimated bullfrogs, and the effect was blocked with the 5-lipoxygenase inhibitor MK-886 (5 x 10(-5) M). These results clearly indicate that the bullfrog brain synthesized both leukotrienes and prostaglandins. Further studies are necessary to determine their function in the amphibian central nervous system.

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Epinephrine stimulates prostaglandin synthesis by bullfrog lung from warm‐acclimated, but not cold‐acclimated, animals

Cited by 6 publications

References 25 publications

Influence of different volume therapy regimens on regulators of the circulation in the critically ill

Influence of different volume therapy regimens on regulators of the circulation in the critically ill

Hormonal and metabolic responses of juvenile alligators to cold shock

Eicosanoid synthesis by warm‐and cold‐acclimated American bullfrog (Rana catesbeiana) brain

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