Episodic memory decline in Parkinson’ s disease: relation with white matter hyperintense lesions and influence of quantification method

Dunet, Vincent; Fartaria, Mário João; Deverdun, Jérémy; Bars, Emmanuelle Le; Maury, Florence; Castelnovo, Giovanni; Kober, Tobias; Cuadra, Meritxell Bach; Gény, Christian; Maréchal, Bénédicte; Champfleur, Nicolas Menjot de

doi:10.1007/s11682-018-9909-x

Cited by 20 publications

(17 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Parkinson's disease; white matter hyperintensities White matter hyperintensities (WMH), commonly associated with aging and cerebral small vessel disease, 1 have been observed on magnetic resonance imaging (MRI) of patients with Parkinson's disease (PD) 2 ; however, their exact role in clinical presentation and disease progression remains controversial. Although some studies demonstrate WMH to be significantly associated with a greater burden of motor dysfunction, mild cognitive impairment, and progression to dementia, [3][4][5][6][7][8][9][10] other studies have found no independent association beyond that of normal aging. [11][12][13][14][15][16][17][18] Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic form of cerebral small vessel disease with hallmark signs of WMH.…”

Section: Discussionmentioning

confidence: 99%

“…The heterogeneity of these reports is further aggravated by the difficulty interpreting findings from studies using different cognitive assessments tools and approaches to measure WMH burden. 4,13 The main strength of our study was the ability to draw data from ONDRI's study design. ONDRI implemented a standardized multicenter, multiplatform approach that enabled the volumetric analysis of MRI-based neurovascular biomarkers and genomic information using validated quantification methods in their respective fields.…”

Section: Discussionmentioning

confidence: 99%

“…White matter hyperintensities (WMH), commonly associated with aging and cerebral small vessel disease, 1 have been observed on magnetic resonance imaging (MRI) of patients with Parkinson's disease (PD) 2 ; however, their exact role in clinical presentation and disease progression remains controversial. Although some studies demonstrate WMH to be significantly associated with a greater burden of motor dysfunction, mild cognitive impairment, and progression to dementia, 3‐10 other studies have found no independent association beyond that of normal aging 11‐18 …”

mentioning

confidence: 99%

See 2 more Smart Citations

Parkinson's Disease, NOTCH3 Genetic Variants, and White Matter Hyperintensities

et al. 2020

View full text Add to dashboard Cite

Background White matter hyperintensities (WMH) on magnetic resonance imaging may influence clinical presentation in patients with Parkinson's disease (PD), although their significance and pathophysiological origins remain unresolved. Studies examining WMH have identified pathogenic variants in NOTCH3 as an underlying cause of inherited forms of cerebral small vessel disease. Methods We examined NOTCH3 variants, WMH volumes, and clinical correlates in 139 PD patients in the Ontario Neurodegenerative Disease Research Initiative cohort. Results We identified 13 PD patients (~9%) with rare (<1% of general population), nonsynonymous NOTCH3 variants. Bayesian linear modeling demonstrated a doubling of WMH between variant negative and positive patients (3.1 vs. 6.9 mL), with large effect sizes for periventricular WMH (d = 0.8) and lacunes (d = 1.2). Negative correlations were observed between WMH and global cognition (r = −0.2). Conclusion The NOTCH3 rare variants in PD may significantly contribute to increased WMH burden, which in turn may negatively influence cognition. © 2020 International Parkinson and Movement Disorder Society

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Parkinson's Disease, NOTCH3 Genetic Variants, and White Matter Hyperintensities

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Whether these deficits are caused by the impairment of encoding or that of retrieval strategy remains controversial. Recently, a study showed that episodic memory function might be related to white matter hyperintense lesions 39 .…”

Section: Discussionmentioning

confidence: 99%

Evaluating Mild Cognitive Dysfunction in Patients with Parkinson’s Disease in Clinical Practice in Taiwan

Lee

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Our study aimed to examine the contribution of commonly used tools, including the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA), and develop a formula for conversion of these tests in the Chinese population. We also create a predictive model for the detection of Chinese patients' mild cognitive impairment (MCI). We recruited 168 patients with Parkinson's disease (PD) from 12 medical centres or teaching hospitals in Taiwan, and each participant received a comprehensive neuropsychological assessment. Logistic regression analysis was conducted to find predictors of MCI with the help of a generalized additive model. We found that patients with an MMSe > 25 or a MoCA > 21 were less likely to have MCI. The discrimination powers of the two tests used for detecting MCI were 0.902 and 0.868, respectively, as measured by the area under the receiver operating characteristic curve (ROC). The best predictive model suggested that patients with a higher MMSE score, delayed recall scores of the 12-item Word Recall Test ≥ 5.817, and no test decline in the visuospatial index were less likely to have MCI (ROC = 0.982). Our findings have clinical utility in MCI detection in Chinese PD and need a larger sample to confirm. Evidence showed that non-motor symptoms are common in patients with movement disorders, Parkinson's disease (PD) 1 , in which cognitive dysfunction is the most troublesome symptom. The patients' cognitive profile is heterogeneous, and it is urgently needed to detect the subtle changes of cognitive function before full-brown dementia 2-4. In the PD population, mild cognitive impairment (MCI) is believed to be a forerunner of dementia, and the prevalence of MCI in PD population is around 26.7% (range: 18.9%-38.2%) 5. For detecting MCI, diagnostic criteria were suggested by the Movement Disorder Society (MDS), and this criterion has two means to clarify PD patients with MCI. The level I contain the usage of screening tools and the level II involved in the multiple neuropsychological assessments 6. Clinically, physicians use brief screening tools to measure the patient's mentality can meet the level I's requirement. That is, Level I has high clinical utility. Two most frequently used screening instruments, Mini-Mental State Examination (MMSE) 7 and the Montreal Cognitive Assessment (MoCA) 8 , applied for screening cognitive dysfunction in patients with Alzheimer's disease (AD) in clinical practice 9. However, their clinical utility in the PD population is disputed, especially in the PD population from Eastern countries. MMSE is a universally accepted test and is a handy tool to detect cognitive dysfunction in PD population 10,11. However, it is prone to ceiling effects and does not provide adequate sensitivity

show abstract

“…Accordingly, imaging and autopsy studies in PD patients have been used to probe for brain changes that predict and/or correlate with the severity of episodic memory impairment. These studies have identified thinning or decreased volume in hippocampus and in medial temporal and frontal lobe cortices ( 42 – 44 ) as well as increased total volumes of white matter hyperintense lesions in the frontal and temporal lobes ( 45 ) as promising candidates. Although less is known about the physiological processes that render episodic memory vulnerable in PD, there are reasons to suspect that biological sex and/or sex hormones play important roles.…”

Section: Introductionmentioning

confidence: 99%

Biological Sex and Sex Hormone Impacts on Deficits in Episodic-Like Memory in a Rat Model of Early, Pre-motor Stages of Parkinson's Disease

et al. 2020

View full text Add to dashboard Cite

Episodic memory deficits are among the earliest appearing and most commonly occurring examples of cognitive impairment in Parkinson's disease (PD). These enduring features can also predict a clinical course of rapid motor decline, significant cognitive deterioration, and the development of PD-related dementia. The lack of effective means to treat these deficits underscores the need to better understand their neurobiological bases. The prominent sex differences that characterize episodic memory in health, aging and in schizophrenia and Alzheimer's disease suggest that neuroendocrine factors may also influence episodic memory dysfunction in PD. However, while sex differences have been well-documented for many facets of PD, sex differences in, and sex hormone influences on associated episodic memory impairments have been less extensively studied and have never been examined in preclinical PD models. Accordingly, we paired bilateral neostriatal 6-hydroxydopamine (6-OHDA) lesions with behavioral testing using the What-Where-When Episodic-Like Memory (ELM) Task in adult rats to first determine whether episodic-like memory is impaired in this model. We further compared outcomes in gonadally intact female and male subjects, and in male rats that had undergone gonadectomy-with and without hormone replacement, to determine whether biological sex and/or sex hormones influenced the expression of dopamine lesioned-induced memory deficits. These studies showed that 6-OHDA lesions profoundly impaired recall for all memory domains in male and female rats. They also showed that in males, circulating gonadal hormones powerfully modulated the negative impacts of 6-OHDA lesions on What, Where, and When discriminations in domain-specific ways. Specifically, the absence of androgens was shown to fully attenuate 6-OHDA lesion-induced deficits in ELM for "Where" and to partially protect against lesion-induced deficits in ELM for "What." In sum, these findings show that 6-OHDA lesions in rats recapitulate the vulnerability of episodic memory seen in early PD. Together with similar evidence recently obtained for spatial working memory, the present findings also showed that diminished androgen levels provide powerful, highly selective protections against the harmful effects that 6-OHDA lesions have on memory functions in male rats.

show abstract

Episodic memory decline in Parkinson’ s disease: relation with white matter hyperintense lesions and influence of quantification method

Cited by 20 publications

References 35 publications

Parkinson's Disease, NOTCH3 Genetic Variants, and White Matter Hyperintensities

Parkinson's Disease, NOTCH3 Genetic Variants, and White Matter Hyperintensities

Evaluating Mild Cognitive Dysfunction in Patients with Parkinson’s Disease in Clinical Practice in Taiwan

Biological Sex and Sex Hormone Impacts on Deficits in Episodic-Like Memory in a Rat Model of Early, Pre-motor Stages of Parkinson's Disease

Contact Info

Product

Resources

About