Episodic migraine and obesity and the influence of age, race, and sex

Peterlin, B. Lee; Rosso, Andrea L.; Williams, Michelle A.; Rosenberg, Jason R.; Haythornthwaite, Jennifer A.; Merikangas, Kathleen R.; Gottesman, Rebecca F.; Bond, Dale S.; He, Jianmei; Zonderman, Alan B.

doi:10.1212/wnl.0b013e3182a824f7

Cited by 92 publications

(121 citation statements)

References 31 publications

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“…A study of 30215 subjects found migraine symptoms in 3791; there was no association between migraine prevalence and increased BMI but an association was found between increased body weight with increased headache incidence and pain severity (25). A recent study in similar age groups found a relationship between migraine and obesity (26,27). Several adipocytokines are released from adipose tissue.…”

Section: Migraine In the Presence Of Insulin Resistance And Obesitymentioning

confidence: 99%

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The Relationship Between Migraine and Nutrition

Özturan¹,

Şanlıer²,

Coşkun³

2016

tnd

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Section: Migraine In the Presence Of Insulin Resistance And Obesitymentioning

confidence: 99%

“…In addition, hypothalamic peptides and nutrition-related neurotransmitters such as orexin and adipokines may contribute to the pathophysiology of migraine. Regulation of the release of these peptides and proteins may trigger or contribute to the development of headache in migraine (26).…”

Section: Migraine In the Presence Of Insulin Resistance And Obesitymentioning

confidence: 99%

The Relationship Between Migraine and Nutrition

Özturan¹,

Şanlıer²,

Coşkun³

2016

tnd

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“…[3][4][5][6] Sphingolipids (e.g., sphingomyelins, ceramides) are a group of bioactive lipids that are critical components of membrane microdomains. 7,8 In addition to important structural roles, these…”

Section: Classification Of Evidencementioning

confidence: 99%

Interictal, circulating sphingolipids in women with episodic migraine

et al. 2015

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Objective: To evaluate interictal, circulating sphingolipids in women migraineurs.Methods: In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n 5 52) and from controls (n 5 36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled with tandem mass spectrometry using multiple reaction monitoring. Multivariate logistic regression was used to examine the association between serum sphingolipids and EM odds. A recursive partitioning decision tree based on the serum concentrations of 10 sphingolipids was used to determine the presence or absence of EM in a subset of participants.Results: Total ceramide (EM 6,502.9 ng/mL vs controls 10,518.5 ng/mL; p , 0.0001) and dihydroceramide (EM 39.3 ng/mL vs controls 63.1 ng/mL; p , 0.0001) levels were decreased in those with EM as compared with controls. Using multivariate logistic regression, each SD increase in total ceramide (odds ratio [OR] 0.07; 95% confidence interval [CI]: 0.02, 0.22; p , 0.001) and total dihydroceramide (OR 0.05; 95% CI: 0.01, 0.21; p , 0.001) levels was associated with more than 92% reduced odds of migraine. Although crude sphingomyelin levels were not different in EM compared with controls, after adjustments, every SD increase in the sphingomyelin species C18:0 (OR 4.28; 95% CI: 1.87, 9.81; p 5 0.001) and C18:1 (OR 2.93; 95% CI: 1.55, 5.54; p 5 0.001) was associated with an increased odds of migraine. Recursive portioning models correctly classified 14 of 14 randomly selected participants as EM or control. Conclusion:These results suggest that sphingolipid metabolism is altered in women with EM and that serum sphingolipid panels may have potential to differentiate EM presence or absence. Classification of evidence:This study provides Class III evidence that serum sphingolipid panels accurately distinguish women with migraine from women without migraine. Neurology ® 2015;85:1214-1223 GLOSSARY BMI 5 body mass index; C1P 5 ceramide-1-phosphate; CI 5 confidence interval; DHC 5 dihydroceramide; DHSM 5 dihydrosphingomyelin; DSM-IV 5 Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition); EM 5 episodic migraine; HIT-6 5 Headache Impact Test-6; LacCer 5 lactosylceramide; MHC 5 monohexosylceramide; OPLS-DA 5 orthogonal partial least squares discriminant analysis; OR 5 odds ratio; PHQ-9 5 Patient Health Questionnaire-9; S1P 5 sphingosine-1-phosphate; SM 5 sphingomyelin.Although the full pathophysiology of migraine is not known, current theories suggest that migraine is largely an inherited brain disorder associated with a sterile, neurogenic inflammation and alterations in neuronal excitability and the cerebrovasculature.1,2 Several lines of evidence also indicate that migraineurs have a greater risk of stroke and disorders related to lipid metabolism including hypercholesterolemia, impaired insulin sensitivity, and obesity. [3][4][5][6] Sphingolipids (e.g., sphingomyelins, ceramides) are a group of bioactive lipids that are critical components of m...

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“…While some studies included adults of all ages, [5][6][7] others were limited to younger 3,8,9 or older [10][11][12] populations, whereas others stratified by age (e.g., ,50 and $50 years). 13,14 Likewise, some studies included both men and women (combined or stratified), 1 whereas others were limited to only women. 3,[9][10][11][12] The operational definition of exposure and outcome categories has also varied substantially across studies.…”

mentioning

confidence: 99%

“…3,[9][10][11][12] The operational definition of exposure and outcome categories has also varied substantially across studies. Although most studies reported using the WHO physical status categories, 15 some compared obese individuals (body mass index [BMI] $30) with those who were nonobese (e.g., underweight, overweight, and normal weight combined [BMI ,30]), 12,14 others compared obese (BMI $30) with normal weight (BMI 18.5-29.9) individuals, 3,13 whereas others compared those in partial obesity grades (e.g., BMI 30-34.9, BMI 35-39.9, BMI $40) with normal weight individuals 6,7,9 (table e-1 at Neurology.org).…”

mentioning

confidence: 99%

Body composition status and the risk of migraine

et al. 2017

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Objective: To evaluate the association between migraine and body composition status as estimated based on body mass index and WHO physical status categories.Methods: Systematic electronic database searches were conducted for relevant studies. Two independent reviewers performed data extraction and quality appraisal. Odds ratios (OR) and confidence intervals (CI) were pooled using a random effects model. Significant values, weighted effect sizes, and tests of homogeneity of variance were calculated.Results: A total of 12 studies, encompassing data from 288,981 unique participants, were included. The age-and sex-adjusted pooled risk of migraine in those with obesity was increased by 27% compared with those of normal weight (odds ratio [OR] 1.27; 95% confidence interval [CI] 1.16-1.37, p , 0.001) and remained increased after multivariate adjustments. Although the age-and sex-adjusted pooled migraine risk was increased in overweight individuals (OR 1.08; 95% CI 1.04, 1.12, p , 0.001), significance was lost after multivariate adjustments. The age-and sex-adjusted pooled risk of migraine in underweight individuals was marginally increased by 13% compared with those of normal weight (OR 1.13; 95% CI 1.02, 1.24, p , 0.001) and remained increased after multivariate adjustments. Conclusions:The current body of evidence shows that the risk of migraine is increased in obese and underweight individuals. Studies are needed to confirm whether interventions that modify obesity status decrease the risk of migraine. Both migraine and obesity are conditions associated with substantial personal and societal burdens.1 As obesity is a potentially modifiable risk factor, the relationship between migraine and obesity has been a focus of research interest for the last decade. [1][2][3] Although several studies support that obesity is associated with an increased risk of migraine, results are inconsistent with regards to included populations, how obesity status is categorized, and other features of individual study design and conduct, and the conclusions drawn.

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Episodic migraine and obesity and the influence of age, race, and sex

Abstract: The odds of EM are increased in those with obesity, with the strongest relationships among those younger than 50 years, white individuals, and women.

Cited by 92 publications

References 31 publications

The Relationship Between Migraine and Nutrition

The Relationship Between Migraine and Nutrition

Interictal, circulating sphingolipids in women with episodic migraine

Body composition status and the risk of migraine

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