Epitendinous Suture Techniques in Extensor Tendon Repairs—An Experimental Evaluation

Henderson, James; Sutcliffe, M.P.F.; Gillespie, Paddy

doi:10.1016/j.jhsa.2011.08.038

Cited by 14 publications

(10 citation statements)

References 28 publications

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“…SIS is used as the wound is kept clean and smooth, and it aligns tissues well. HMS is chiefly used in big tension wounds, in repair of blood vessel rupture or in closing the peritoneum, to create a smooth inner wall (2,3). However, the differences in the resulting fibrotic processes of the two types of suture remain to be clarified.…”

Section: Introductionmentioning

confidence: 99%

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Effects of different sutures on fibrosis and wound healing in a rabbit model of corneal wounds

Liu

Chen

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the study was to investigate wound healing and scar formation in rabbit corneal lamellar wounds repaired with simple interrupted sutures (SIS) or horizontal mattress sutures (HMS). Two parallel ‘I’-shaped lamellar cornea wounds were created in one eye of 40 white New Zealand rabbits, while 5 uninjured rabbits were sacrificed to serve as normal controls. One side of the wounds, in the test rabbits, was closed with SIS, while the other side was treated with HMS. Ten days later, the stitches were removed under anesthesia. The animals were sacrificed on days 14 and 21, and months 3 and 6 after the suturing surgery, and corneal samples were subjected to histological and immunofluorescent studies: α-smooth muscle actin (α-SMA) and vimentin were used to detect myofibroblasts and fibroblasts, respectively, and collagen type I and III was used to detect extracellular matrix (ECM) deposition. Relevant mRNA levels were assessed by quantitative polymerase chain reaction (qPCR) to elucidate the differences in wound healing and formation of fibrosis. Macroscopic and hematoxylin and eosin staining observations showed that the two sides of the wounds developed the most prominent fibrotic tissue on day 21. The immunofluorescence and qPCR results showed that HMS wounds produced increased α-SMA, vimentin and collagen type III compared to the SIS wounds on day 14 or 21. The collagen type I expression showed no distinctive difference in SIS and HMS wounds. In conclusion, corneal lamellar wounds treated with SIS developed less fibrotic-related proteins and related mRNA in the early stages of wound healing than wounds treated with HMS. Although differences were not distinct after 3 months, the results of the present study suggest a benefit in choosing SIS over HMS, as at least the initial fibrotic process seems more benign with SIS. Corneal wounds should be carefully sutured, ensuring the tissue is well aligned.

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Section: Introductionmentioning

confidence: 99%

“…Since the cornea is transparent, avascular and composed of simple substances, it is an ideal site to investigate the process of wound healing (2). When the cornea is injured, the quiescent keratocytes in the wound stroma become apoptotic, and the keratocytes nearby are activated.…”

Section: Introductionmentioning

confidence: 99%

Effects of different sutures on fibrosis and wound healing in a rabbit model of corneal wounds

Liu

Chen

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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“…106 In a separate ex vivo study, pulley-wrapped tension was applied to the tendon to better simulate gliding over bony surfaces. 107 In this case, the interrupted horizontal mattress technique proved to be significantly more effective in regards to ultimate tensile strength and resistance to gapping. An in vivo approach to this problem provides a more comprehensive perspective on this issue, as biological healing factors and cyclic loading are taken into account.…”

Section: Flexormentioning

confidence: 77%

“…99 In the past, the canine model was relied upon to perform research on flexor tendons. 98-100 More recently, a wider variety of animals have been used to characterise flexor tendon injury and repair, including chicken, 101 canine, 102-104 ovine, 105 porcine, 106,107 and rabbit 105-110 models. The best choice of model system will depend on the essential characteristics that must be mimicked for a particular research question.…”

Section: Flexormentioning

confidence: 99%

The role of animal models in tendon research

Hast

Zuskov

Soslowsky

2014

Bone & Joint Research

113

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Tendinopathy is a debilitating musculoskeletal condition which can cause significant pain and lead to complete rupture of the tendon, which often requires surgical repair. Due in part to the large spectrum of tendon pathologies, these disorders continue to be a clinical challenge. Animal models are often used in this field of research as they offer an attractive framework to examine the cascade of processes that occur throughout both tendon pathology and repair. This review discusses the structural, mechanical, and biological changes that occur throughout tendon pathology in animal models, as well as strategies for the improvement of tendon healing.Cite this article: Bone Joint Res 2014;3:193–202.

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“…Of the four traditional techniques, the Kessler suture and the Bunnell suture have been shown to be stronger than the mattress or fi gure of eight sutures [ 30 ]. More recently, there has been interest in the use of epitendinous sutures [ 31 ], such as the Silfverskiold suture or a running interlocking horizontal mattress suture [ 32 ], both of which have been shown to be stronger than the core suture techniques.…”

Section: Principles Of Surgical Treatment For Open Injuriesmentioning

confidence: 99%

Injuries: Tendon – Extensor

Knight

2014

Disorders of the Hand

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Epitendinous Suture Techniques in Extensor Tendon Repairs—An Experimental Evaluation

Cited by 14 publications

References 28 publications

Effects of different sutures on fibrosis and wound healing in a rabbit model of corneal wounds

Effects of different sutures on fibrosis and wound healing in a rabbit model of corneal wounds

The role of animal models in tendon research

Injuries: Tendon – Extensor

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