Epithelial atypia and squamous metaplasia in nasal polyps

Baird, A. R.; Hilmi, Omar; White, Paul S.; Robertson, A J

doi:10.1017/s002221510014160x

Cited by 12 publications

(10 citation statements)

References 4 publications

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“…Baird et al 15 in a study of 20 cases of nasal polyps found that 50% of the lesions showed squamous metaplasia and 15% showed atypical changes in the lining mucosal membrane. They concluded that squamous metaplasia was much commoner than previously thought.…”

Section: Resultsmentioning

confidence: 99%

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Clinicopathological study of nasal polyps with special reference to mast cells in inflammatory polyps

Shulbha¹,

Dayananda²

2012

Basic and Applied Pathology

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Background and aim: Nasal polyposis is a relatively common condition found in 1–4% of the general population and in high percentages of some groups of patients. Nasal polyps diagnosed clinically are not always of inflammatory origin. A variety of non‐neoplastic and neoplastic conditions can present as nasal polyps. The aim of this study was to determine the various histopathological types, the predominant cells involved in the pathogenesis of inflammatory polyps with special reference to mast cells and to correlate them clinicopathologically. Methods: A total of 100 cases clinically diagnosed as nasal polyp, were studied over a period of 18 months. Results: Out of 100 cases studied, 91% of them were non‐neoplastic and 9% were neoplastic. Among the non‐neoplastic conditions, non‐allergic polyps accounted for 70% and allergic polyps accounted for 21% of cases. Among the neoplastic lesions, 6% were benign and 3% malignant. Squamous metaplasia was seen in 16.38% of cases. In stroma, mononuclear cells were predominant in 63.7% of inflammatory polyps, eosinophils in 19.11%, prominent edematous stroma in 26.39%, and vasculature > 2/high power field (hpf) in 20.39% of inflammatory polyps. 0–5 mast cells per 10 hpf were seen in 97.8% of inflammatory polyps in epithelium, whereas 11–20 mast cells in 26.4% of inflammatory polyps were seen in stroma. Conclusions: Nasal polyps diagnosed clinically are not always of inflammatory origin and therefore have to be subjected for histopathology.

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Section: Resultsmentioning

confidence: 99%

“…Baird et al 15 . in a study of 20 cases of nasal polyps found that 50% of the lesions showed squamous metaplasia and 15% showed atypical changes in the lining mucosal membrane.…”

Section: Discussionmentioning

confidence: 98%

Clinicopathological study of nasal polyps with special reference to mast cells in inflammatory polyps

Shulbha¹,

Dayananda²

2012

Basic and Applied Pathology

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“…Baird et al, in a short period of time such as eight months, showed the existence of atypia in fi ft een nasal polypectomy specimens containing squamous metaplasia (22). Th e study shows that preoperative complaint period of patients with metaplasia is longer than those without metaplasia.…”

Section: Discussionmentioning

confidence: 95%

Is there any relationship between the clinical, radiological and histopathologic findings in sinonasal polyposis?

Akbay¹,

Özgür²,

Çokkeser³

2013

TJPATH

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“…20 One unexpected finding in this study was squamous metaplasia in two specimens in the control group. A study by Baird et al 21 of 20 patients with nasal polyps found that 50% showed squamous metaplasia. They attributed this finding to chronicity of the disease.…”

Section: Discussionmentioning

confidence: 98%

Low Frequency Ultrasound in Chronic Rhinosinusitis with Nasal Polyposis and Recovery after Endoscopic Sinus Surgery: A Randomized Controlled Trial

Castro¹,

Cruz-Daylo²,

Jardin³

2017

Philipp J Otolaryngol Head Neck Surg

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Objective: The study aimed to determine the role of low frequency ultrasound in patients with Chronic Rhinosinusitis with Nasal Polyposis (CRS-NP) and recovery after Endoscopic Sinus Surgery (ESS) using Sino Nasal Outcome Test 22 (SNOT-22) questionnaires, modified Lund MacKay endoscopic appearance, and histopathologic examination. Methods: Study design: Single Blinded Randomized Controlled Trial Setting: Tertiary government hospital Subjects: 42 adult Filipinos aged 19 to 76 years-old diagnosed with Chronic Rhinosinusitis with grade 2 and 3 Nasal Polyposis and failure of maximal medical management (3-month course of antibiotics, nasal douche, topical steroids and other modalities) between June 2013 to June 2015 were randomized into two groups of 21 participants each-- the ultrasound-treated group and control group. Specimens (nasal polyps) from both groups were obtained and processed with Hematoxylin-Eosin (H&E) and gram staining. Specimens from the ultrasound-treated group received low frequency ultrasound (1 MHz, 1.0 watt/cm2, 20% pulsed mode, for 5 minutes at 370C) post-extraction and prior to staining. In phase II, the ultrasound group also received the same ultrasound treatment while the control group underwent ultrasound at 0 MHz frequency, 0 watt/cm2, both twice a week for 3 weeks, beginning one (1) week post operatively. Both groups accomplished SNOT-22 forms and were evaluated via modified Lund MacKay endoscopic appearance at 1 week (week 0 of treatment), 2 weeks, 3 weeks, and 1 month post operatively (week 3 of treatment). Results: Paired T-test showed a statistically significant difference between control and treatment groups in epithelial thickness with a p-value of 2.29E-10 (average of 73.34um for controls and 31.1um for the treatment group) at 95% confidence interval. The inflammatory cell count also differed significantly between control and treatment groups (average 293.85 and 29.65 inflammatory cells per high-power field in 10 random microscopic fields, respectively), p-value of 1.05E-17 on paired T-test; CI 95%. In phase II of the study, SNOT-22 results showed significant differences in improvement of symptoms in ultrasound-treated patients after Endoscopic Sinus Surgery (weekly mean scores of 38.05, 21, 11.3, and 10.45) and in modified Lund Mackay endoscopic appearance scores (weekly mean scores of 7.88, 4.35, 3.02, 2.08). Two-way analysis of variance showed significant differences between control and treatment groups for both SNOT-22 (p = 1.07E-80; 9.71E-119; CI 95%) and modified Lund Mackay endoscopic appearance scores (p = 3.89E-60; 1.85E-95; CI 95%). Conclusion: Low frequency therapeutic ultrasound demonstrated possible efficacy as an agent in disrupting epithelial architecture in patients with CRS-NP as well as in symptom improvement after endoscopic sinus surgery patients based on histopathologic evaluation, SNOT-22 and modified Lund MacKay endoscopic appearance scores. Low frequency ultrasound may be an adjuvant to conventional medical treatment in CRS-NP. Keywords: Biofilm, Sinusitis, Nasal Polyps, Chronic disease, Ultrasonic therapy

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Epithelial atypia and squamous metaplasia in nasal polyps

Cited by 12 publications

References 4 publications

Clinicopathological study of nasal polyps with special reference to mast cells in inflammatory polyps

Clinicopathological study of nasal polyps with special reference to mast cells in inflammatory polyps

Is there any relationship between the clinical, radiological and histopathologic findings in sinonasal polyposis?

Low Frequency Ultrasound in Chronic Rhinosinusitis with Nasal Polyposis and Recovery after Endoscopic Sinus Surgery: A Randomized Controlled Trial

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