Is there any relationship between the clinical, radiological and histopathologic findings in sinonasal polyposis?

Akbay, Ercan; Özgür, Tümay; Çokkeser, Yaşar

doi:10.5146/tjpath.2013.01163

Cited by 5 publications

(5 citation statements)

References 16 publications

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“…However, both ciliated and squamous epithelium can sometimes be found in polyp tissue depending of its origin. 3,4 The history, physical examination, CT scan and nasopharyngoscopic findings were highly suggestive of a polyp but were not supported by histopathology. We therefore defined this nasopharyngeal tissue in the present report as being a polypoid mass.…”

Section: Discussionmentioning

confidence: 98%

Cryptococcal nasopharyngeal polypoid mass in a cat

Livet

Javard

Alexander

et al. 2015

Journal of Feline Medicine and Surgery Open Reports

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Case summaryAn indoor 9-year-old castrated male domestic cat was referred with a 4 month history of increased upper airway noise. Computed tomography revealed a nasopharyngeal polypoid mass, which was removed endoscopically with basket forceps. Histopathology was compatible with a polypoid granulomatous pharyngitis with Cryptococcus-like organisms. This was supported by a positive serum latex cryptococcal antigen agglutination test (LCAT). Minimal inflammation of the nasal tissue was noted on histopathology, with no evidence of fungus. Following endoscopic removal of the mass, the patient was treated with systemic antifungal medication (itraconazole). One year after diagnosis, the LCAT titer was negative and the cat remained free of clinical signs.Relevance and novel informationThis case report emphasizes the importance of considering Cryptococcus species as a potential etiology in cats presented with signs of nasopharyngeal obstruction with an isolated nasopharyngeal polypoid mass, even if kept indoors.

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Section: Discussionmentioning

confidence: 98%

Cryptococcal nasopharyngeal polypoid mass in a cat

Livet

Javard

Alexander

et al. 2015

Journal of Feline Medicine and Surgery Open Reports

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“…[1][2][3]6 Nasal polyposis is considered to be grouped into eosinophilic and non-eosinophilic types, but among various attempts to further divide the nasal polyps based on inflammatory cells, in one of the subdivisions they can be clustered into five types depending on the presence and predominance of lymphocytes, plasma cells, eosinophils, neutrophils, and mixed inflammatory cells. 3,5,7 This pattern of results about the diverse distribution of type and population of the inflammatory cell can be explained as, sinonasal polyposis, commonly also known as Chronic Rhinosinusitis with Nasal Polyps, i.e., CRSwNP, is characteristically a heterogeneous disease with several etiologies and multiple predisposing factors. Nasal polyposis cases follow the pattern of inflammation that fluctuates considerably by geographical region and ethnicity and keeps evolving.…”

Section: Discussionmentioning

confidence: 99%

“…Histopathologic differences may also arise according to the status of polyp, history of radiation exposure, gender and odontogenic infections. [5][6][7][8][9][10] There are three distinct patterns of inflammation seen in sinonasal tissue, with predominant eosinophilic infiltration in Th2 inflammation. Similarly, the abundance of Lymphocytes, Mast cells, and plasma cells is also strong evidence of Th2 determined inflammatory process.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the study on the second-generation Asian Mongolian residing in the United States revealed a non-inflammatory Th1-Th17 pattern for CRSwNP. 4,5 This type of study is lacking in Aryan or Indian sub origin including the population of Bangladesh, Pakistan, Afghanistan, Sri Lanka and other Arab countries. Hence, the present study, which is unique in its own type is designed to examine the Th1/ Th2/Th17 inflammatory pattern in the Indian sub origin population based on the study of inflammatory cellular distribution and cellular phenotypes in the tissue of Sino-nasal polyposis.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory cell distribution accrediting Th2 inflammation in Sinonasal polyp in Indian Population

Singh¹,

Kumari

Mishra³

et al. 2022

IJOAS

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The pathophysiology of Chronic Rhino-Sinusitis with Nasal Polyposis (CRSwNP) showed distinct ethnic and geographic differences whereas the Western Caucasian population revealed Th2 eosinophilic inflammation in contrary to the Asian Mongolian population with Th1-Th17 non-eosinophilic inflammatory pattern. Prospective Observational study was undertaken from December 2019 to December 2021 on 50 patients who were diagnosed to have sinonasal polyposis. The collected polyp tissue was sent to the histopathological department for further microscopic evaluation. The types of inflammatory cell infiltrate studied in the tissue specimens obtained during surgery included lymphocytes, eosinophils, neutrophils, mast cells, and plasma cells. The age of patients ranged from 11 to 70 years with a mean age of 31.80±17.69 years. The male to female ratio was 1.3:1. The 62% of patients showed the predominance of eosinophil which was of grade III and grade IV category, Lymphocyte infiltrate of grades III and IV was present in 46% of cases, Mast cell was 30% and 10% of grade III and Grade IV respectively, and the Neutrophils were found only in 22% and 105 of cases of grade III & Grade IV, respectively which was the least of all inflammatory cells found in polyp tissue. The cellular predominance was shifted toward the Th2 type of inflammation with the predominance of Eosinophil, Lymphocytes, Plasma cells, and mast cells in the Asian Aryan sub origin population contrary to the Th17 type of inflammation as indicated by the least infiltration of Neutrophils as reported in Asian Mongolian Populations.

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“…Numerous inflammatory cells can be identified in polypous tissue, including lymphocytes, plasmocytes, macrophages, eosinophils, and basophils, and under certain conditions with proliferation of blood vessels, fibrosis, and tissue necrosis [6,7]. The increased number of activated eosinophils, neutrophils and plasmocytes in the nasal polyps, as compared to the normal nasal mucosa, suggests that inflammatory processes play an important role in the pathophysiology of nasal polyps [8].…”

Section:  Introductionmentioning

confidence: 99%

Involvement of inflammatory cells in chronic rhinosinusitis with nasal polyps

Enache

Ioniță

Anghelina³

et al. 2021

Rom J Morphol Embryol

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Inflammation plays an important role in the pathogenesis of nasal polyps. Understanding the biomolecular action mechanisms of inflammatory elements can contribute to improving the prognosis of these lesions. The study analyzed the distribution and immunohistochemically quantified eosinophils [eosinophil major basic protein (BMK-13)], lymphocytes [cluster of differentiation (CD) 4, CD8, CD20] and plasmocytes (CD138) in both the epithelial and stromal compartment in relation to composite scores, which included specific histopathological parameters for 50 sinonasal polyps. Inflammatory elements predominated at stromal level, the high histological composite scores being frequently associated with increased expression of inflammatory elements. Also, the numerical distribution of inflammatory elements indicated positive linear relations within the groups BMK-13/CD8 and CD4/CD20/CD138, and a negative linear relation between the two groups. This aspect can support the existence of alternative or sequential pathogenic mechanisms involved in the pathogenesis of sinonasal polyps, and the results obtained can be used for a better stratification of patients in order to optimize the therapy.

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Is there any relationship between the clinical, radiological and histopathologic findings in sinonasal polyposis?

Cited by 5 publications

References 16 publications

Cryptococcal nasopharyngeal polypoid mass in a cat

Cryptococcal nasopharyngeal polypoid mass in a cat

Inflammatory cell distribution accrediting Th2 inflammation in Sinonasal polyp in Indian Population

Involvement of inflammatory cells in chronic rhinosinusitis with nasal polyps

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