Epithelial Dysplasia in Endoscopic Gastric Mucosal Biopsies

Farini, R; Leandro, Gioacchino; Farinati, Fabio; Mario, F. Di; Scalabrin, G.; Mazzucato, B; Cecchetto, Attilio; Naccarato, R.

doi:10.1177/030089168106700614

Cited by 10 publications

(2 citation statements)

References 9 publications

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“…Dysplasia is fairly often documented in asso ciation with GU [9], particularly when it is relapsing [8], In this series, epithelial dyspla sia affected only patients older than 40. Its peak preceded that of GC, supporting the hypothesis of dysplasia being a morphologi cal precursor of the tumor.…”

Section: Discussionmentioning

confidence: 75%

Gastric Ulcer and Stomach Aging: Pathophysiology and Clinical Implications

Farinati¹,

Cardin²,

Mario³

et al. 1988

Gerontology

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138 consecutive patients with endoscopically and histologically confirmed benign gastric ulcer were investigated in order to evaluate the relationship between aging and parameters relating to gastric ulcer pathophysiology and natural history: prevalence in dyspeptic patients referred to an endoscopic unit, recurrences, gastric acid secretory capacity, peptic activity, incidence of precancerous and neoplastic changes. On the basis of our results, different populations of gastric ulcer patients seem to be identifiable: (1) young patients (aged under 40), with low prevalence and recurrence rates, with acid capacity above normal range, high peptic activity and no risk for precancerous or neoplastic changes, (2) middle-aged subjects (41–50), with high prevalence and recurrence rates, high peptic activity and acid activity within the normal range, atrophic gastritis, intestinal metaplasia, dysplasia and low incidence of cancer, and (3) elderly patients (aged over 50), with lower prevalence and recurrence rates, frequent association with chronic atrophic gastritis, impaired acid and peptic secretion, in whom one may observe either an association of the ulceration with cancer or evolution of dysplasia into neoplasia. These observations confirm that elderly and middle-aged gastric ulcer patients should undergo routine follow-up, and that pathophysiological data should be taken into account before deciding upon antiulcer therapy.

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Section: Discussionmentioning

confidence: 75%

Gastric Ulcer and Stomach Aging: Pathophysiology and Clinical Implications

Farinati¹,

Cardin²,

Mario³

et al. 1988

Gerontology

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show abstract

“…In parallel with experience in other organs, precancerous dysplasia has been defined. [1][2][3][4][5][6] These definitions are a subjective assessment of increasing architectural and cytological atypia which fall short of the diagnosis of carcinoma and require the skills of an experienced pathologist.…”

Section: Introductionmentioning

confidence: 99%

Morphometric analysis of gastric dysplasia

Jarvis

Whitehead

1985

The Journal of Pathology

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The grading of gastric epithelial dysplasia has been studied by means of computer aided morphometry. Measurements of histological features were made on segments of epithelium from 38 selected cases of dysplasia graded by subjective assessment. The measurements were statistically compared with the subjective scores using discriminant analysis. The measurements were found to provide significant discrimination between all groups. Nuclear size proved to be the main discriminating variable. Prediction of the likely group membership of individual cases was possible using classification equations derived from the discriminant analysis. Classification of the original data set revealed prediction errors which suggested a bias against diagnosis of dysplasia. As a result of this study reliable, repeatable and objective gradings of gastric epithelial dysplasia can be obtained by inexperienced persons with an accuracy approaching that of a skilled pathologist.

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Carcinoembryonic antigen in gastric juice collected during endoscopy. Value in detecting high-risk patients and gastric cancer

Nitti

Farini²,

Grassi

et al. 1983

Cancer

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In order to ascertain the role of gastric carcinoembryonic antigen (CEA) determination in detecting patients with a risk for gastric cancer, 69 subjects were studied; 23 were referred for endoscopy because of dyspepsia but without obvious macroscopic lesions, 27 with duodenal ulcer, 11 with benign gastric ulcer, 8 with gastric cancer. The following results were obtained by subdividing the material according to the histologic interpretation of the results of gastric mucosal biopsies: (1) in the presence of minor histologic abnormalities of the gastric mucosa, CEA in gastric juice was under 100 ng/ml in all but five cases; and (2) in moderate or severe chronic atrophic gastritis (associated or otherwise with intestinal metaplasia or dysplasia), and in gastric cancer, gastric CEA ranged between 224 and 3120 ng/ml in all but two cases. Although not diagnostic for gastric cancer, gastric CEA is a promising test in detecting patients at risk, including those with dysplasia of the gastric mucosa. Cancer 52:2334‐2337, 1983.

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Epithelial Dysplasia in Endoscopic Gastric Mucosal Biopsies

Cited by 10 publications

References 9 publications

Gastric Ulcer and Stomach Aging: Pathophysiology and Clinical Implications

Gastric Ulcer and Stomach Aging: Pathophysiology and Clinical Implications

Morphometric analysis of gastric dysplasia

Carcinoembryonic antigen in gastric juice collected during endoscopy. Value in detecting high-risk patients and gastric cancer

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