Epithelial-mesenchymal transition related to bone invasion in oral squamous cell carcinoma

Vanini, Jaqueline Vaz; Koyama, Leonardo Kenji Sakaue; Matos, Leandro Luongo de; Junior, José Martins Figueredo; Cernea, Cláudio Roberto; Nagano, Cibele Pidorodeski; Coutinho‐Camillo, Cláudia Malheiros; Hsieh, Ricardo; Lourenço, Sílvia Vanessa

doi:10.1016/j.jbo.2022.100418

Cited by 2 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, a large body of studies has evaluated the diagnostic/prognostic value of surveilling key players in the growth, survival, invasion, and differentiation of oral epithelial cells and biological events deregulated in OPMDs and OSCCs [ 13 , 14 , 15 , 16 , 17 ]. Among the markers examined in the aforementioned studies are the basic helix-loop-helix twist homolog (TWIST) transcription factors, the Ki67 cell proliferation marker, the Bcl-2 survival factor, the pro-apoptotic Bax, the protein kinase B (AKT), the pro-invasive matrix metalloproteinases (MMPs), the cell membrane cadherins and connexins, and cytoskeleton components such as keratins or vimentin [ 13 , 14 , 15 , 16 , 17 ]. Further work has focused on the modulators of biological processes that are altered during oral carcinogenesis, such as the remodeling of the extracellular matrix (ECM) [ 18 , 19 , 20 , 21 , 22 ], the metabolism of glucose [ 23 ], and the inflammatory response [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

The Multiple Roles of CD147 in the Development and Progression of Oral Squamous Cell Carcinoma: An Overview

Barillari

Melaiu

Gargari

et al. 2022

IJMS

View full text Add to dashboard Cite

Cluster of differentiation (CD)147, also termed extracellular matrix metalloprotease inducer or basigin, is a glycoprotein ubiquitously expressed throughout the human body, the oral cavity included. CD147 actively participates in physiological tissue development or growth and has important roles in reactive processes such as inflammation, immunity, and tissue repair. It is worth noting that deregulated expression and/or activity of CD147 is observed in chronic inflammatory or degenerative diseases, as well as in neoplasms. Among the latter, oral squamous cell carcinoma (OSCC) is characterized by an upregulation of CD147 in both the neoplastic and normal cells constituting the tumor mass. Most interestingly, the expression and/or activity of CD147 gradually increase as healthy oral mucosa becomes inflamed; hyperplastic/dysplastic lesions are then set on, and, eventually, OSCC develops. Based on these findings, here we summarize published studies which evaluate whether CD147 could be employed as a marker to monitor OSCC development and progression. Moreover, we describe CD147-promoted cellular and molecular events which are relevant to oral carcinogenesis, with the aim to provide useful information for assessing whether CD147 may be the target of novel therapeutic approaches directed against OSCC.

show abstract