Epithelial-myoepithelial carcinoma of salivary glands.

Simpson, Roderick H.W.; Clarke, Tom; Sarsfield, P.; Gluckman, P

doi:10.1136/jcp.44.5.419

Cited by 115 publications

(89 citation statements)

References 18 publications

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“…The biphasic pattern of epithelial-myoepithelial carcinoma, showing basaloid and clear cells as well as a surrounding hyaline substance, is sufficiently characteristic for the diagnosis [12]. Immunohistochemical methods help to identify the two layers when they are morphologically indistinct [14]. Immunohistochemically the inner cells are positive for cytokeratin [5,14] and EMA [5,12,14].…”

Section: Discussionmentioning

confidence: 98%

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Epithelial-Myoepithelial Carcinoma of the Nasopharynx

Imate¹,

Yamashita²,

Endo³

et al. 2000

ORL

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We present a patient with a rare epithelial-myoepithelial carcinoma of the nasopharynx with a typical biphasic histopathologic pattern. Immunohistochemical findings support the concept that the inner cells differentiate to ductal epithelium and the outer cells to myoepithelium. In this patient complete excision of the tumor and reconstruction with a pedicled sternocleidomastoid myocutaneous flap were performed. A DNA diploid pattern from flow cytometric study indicates a favorable prognosis. There was no recurrence nor metastasis for 55 months.

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Section: Discussionmentioning

confidence: 98%

“…Immunohistochemical methods help to identify the two layers when they are morphologically indistinct [14]. Immunohistochemically the inner cells are positive for cytokeratin [5,14] and EMA [5,12,14]. The outer cells are positive for S-100 protein [5,12,14] and muscle actin [5,12].…”

Section: Discussionmentioning

confidence: 99%

Epithelial-Myoepithelial Carcinoma of the Nasopharynx

Imate¹,

Yamashita²,

Endo³

et al. 2000

ORL

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“…There are few reports on the effectiveness of different treatment modalities, although wide surgical excision is considered the treatment of choice [24]. Adjuvant radiotherapy maybe of use in preventing local recurrence [25,26]. The role of chemotherapy is uncertain.…”

Section: Discussionmentioning

confidence: 99%

Epithelial-Myoepithelial Carcinoma of Parotid Gland—A Surprising Clinical Entity

Bakshi¹,

Budhiraja²,

Gupta³

et al. 2012

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Objective: Objective of this study is to highlight the importance of considering clinical and radiological findings in parotid tumors before operating tumors with high suspicion of malignancy though reported as benign on histopathology. Material and Methods: 20 years old female patient underwent radical parotidectomy for epithelial-myoepithelial carcinoma of the left parotid gland which was diagnosed on FNAC. Contrast CT and contrast MRI also showed a tumor involving left parotid gland with destruction of ramus of mandible and loss of tissue planes medially & laterally. Facial nerve was infiltrated by tumor, thus sacrificed. Post operatively, patient had left facial palsy and was discharged after 7 days without any other sequelae. Postoperative histopathology showed pleomorphic adenoma with positive resection margins medially, superiorly & posteriorly. No further treatment was given in view of the benign nature of the tumor. Results: Patient was kept on monthly follow up and was disease free at one year follow up. Conclusion: Aggressive surgical treatment should be planned for malignant parotid tumors to give a better tumor free survival. Misdiagnosis can occur on FNAC as it can hit only one part of the tumor thus missing a malignant tumor or can interpret pleomorphic adenoma as epithelial-myoepithelial carcinoma.

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“…Dedifferentiation in salivary gland carcinomas other than ADCC is a rare but well recognized phenomenon and has been documented in epithelial-myoepithelial carcinoma (EMECa) [34][35][36][37][38], acinic cell carcinoma [39][40][41][42][43][44], mucoepidermoid carcinoma [45,46], polymorphous low-grade adenocarcinoma [47,48], hyalinizing clear cell carcinoma [49] and salivary duct carcinoma [50][51][52][53]. In the dedifferentiated (recurrent) acinic cell carcinoma presented by Piana et al [42], there was evidence of myoepithelial differentiation (clear cell morphology, widespread positivity for S100 protein and focal immunoreactivity for SMA).…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Myoepithelial Carcinoma of the Sinonasal Tract: an Underrecognized Salivary-Type Tumor Among the Sinonasal Small Round Blue Cell Malignancies? Report of One Case and a Review of the Literature

Petersson

Chao

2010

Head and Neck Pathol

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We present a 45 year old female patient with a nasal carcinoma showing high-grade/anaplastic histomorphological features and with a distinct myoepithelial immunohistochemical phenotype including positivity for smooth muscle actin, p63, S100 protein with no sustentacular pattern, calponin, cytokeratin 14, vimentin and cytokeratins (AE1-3 and CK5/6). A minority (\5%) of the cells showed focal and variable immunoreactivity for EMA with no cuticular/canalicular pattern. Bcl-2, CD99, CD117 and CD56 were variously positive, but chromogranin and synaptophysin were negative. Weak to moderate nuclear p53 immunoreactivity was seen in 50% of tumor cells. Mib-1/Ki-67 showed an average proliferation of 60-70%. Fluorescent in situ hybridization revealed no EWS-gene translocation. In situ hybridization for EBER was negative.

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Epithelial-myoepithelial carcinoma of salivary glands.

Cited by 115 publications

References 18 publications

Epithelial-Myoepithelial Carcinoma of the Nasopharynx

Epithelial-Myoepithelial Carcinoma of the Nasopharynx

Epithelial-Myoepithelial Carcinoma of Parotid Gland—A Surprising Clinical Entity

Anaplastic Myoepithelial Carcinoma of the Sinonasal Tract: an Underrecognized Salivary-Type Tumor Among the Sinonasal Small Round Blue Cell Malignancies? Report of One Case and a Review of the Literature

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