Epithelial ovarian cancer inherent resistance: May the pleiotropic interaction between reduced immunosurveillance and drug-resistant cells play a key role?

Laganà, Antonio Simone; Sofo, Vincenza; Vitale, Salvatore Giovanni; Triolo, Onofrio

doi:10.1016/j.gore.2016.09.004

Cited by 51 publications

(30 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recurrant oviarian cancer typically poorly responds to first, and sometimes even second line chemotherapy. In this scenario, it possible that the ovarian cancer inherent resistance may be due to reduced immunosurveillance and drugresistant cells [18,19]. Surgical removal of drug-resistant tumors can obtain the maximum clinical benefit.…”

Section: Discussionmentioning

confidence: 99%

Preoperative serum levels of HE4 and CA125 predict primary optimal cytoreduction in advanced epithelial ovarian cancer: a preliminary model study

Feng

Liao

2020

J Ovarian Res

View full text Add to dashboard Cite

Objective: The aim of this study is to establish a noninvasive preoperative model for predicting primary optimal cytoreduction in advanced epithelial ovarian cancer by HE4 and CA125 combined with clinicopathological parameters. Methods: Clinical data including preoperative serum HE4 and CA125 level of 83 patients with advanced epithelial ovarian cancer were collected. The sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy of each clinical parameter were calculated. The Predictive Index score model and the logistic model were constructed to predict the primary optimal cytoreduction. Results: Optimal surgical cytoreduction was achieved in 62.65% (52/83) patients. Cutoff values of preoperative serum HE4 and CA125 were 777.10 pmol/L and 313.60 U/ml. (1) Patients with PIV ≥ 6 may not be able to achieve optimal surgical cytoreduction. The diagnostic accuracy, NPV, PPV and specificity for diagnosing suboptimal cytoreduction were 71, 100, 68, and 100%, respectively. (2) The logistic model was: logit p = 0.12 age − 2.38 preoperative serum CA125 level − 1.86 preoperative serum HE4 level-2.74 histological type-3.37. AUC of the logistic model in the validation group was 0.71(95%CI 0.54-0.88, P = 0.025). Sensitivity and specificity were 1.00 and 0.44, respectively. Conclusion: Age, preoperative serum CA125 level and preoperative serum HE4 level are important non-invasive predictors of primary optimal surgical cytoreduction in advanced epithelial ovarian cancer. Our PIV and logistic model can be used for assessment before expensive and complex predictive methods including laparoscopy and diagnostic imaging. Further future clinical validation is needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Preoperative serum levels of HE4 and CA125 predict primary optimal cytoreduction in advanced epithelial ovarian cancer: a preliminary model study

Feng

Liao

2020

J Ovarian Res

View full text Add to dashboard Cite

show abstract

“…Cancer cell drug-resistance mechanisms play a critical role [34,35]. A growing notion is that reduced immune surveillance and immune escape also plays a crucial role in cancer progression [36,37]. Yet, evidence suggests that certain types of chemotherapy may in fact reboost tumor immune response by inducing immunogenic cell death [20].…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of baseline T cells, B cells and neutrophil-lymphocyte ratio (NLR) in recurrent ovarian cancer treated with chemotherapy

et al. 2020

View full text Add to dashboard Cite

Purpose: Biomarkers are needed to guide treatment decisions in recurrent ovarian cancer, as a high proportion of patients do not benefit from treatments. Data on immune subsets in patients receiving chemotherapy are scarce. We investigated the impact of T cells, B cells, neutrophils and the neutrophil-lymphocyte ratio (NLR) in ovarian cancer patients receiving palliative chemotherapy. Methods: Blood samples were collected prospectively at baseline in recurrent ovarian cancer (N = 72) receiving chemotherapy. T cells, B cells, neutrophils, and NLR were analyzed. Primary and secondary endpoints were overall survival (OS) and treatment response, respectively. Cutoffs for T and B cells were predefined. Results: In patients with low vs. high T and B cells counts, OS was 6.1 months vs 12.0 months (P = 0.017) and 6.1 months vs 12.0 months (P = 0.011, respectively. Low T and B cells analyzed as continuous variables were also associated with unfavorable OS, P = 0.011 and P = 0.007, respectively. Neutrophils had no significant prognostic impact. Median NLR was 4.1. High vs. low NLR was associated with poor survival, 7.4 months vs. 15.9 months (P = 0.012). In multivariate analysis including platinum sensitivity, number of prior lines of chemotherapy, and performance status, high NLR remained an independent poor prognostic factor HR: 2.17 (95% CI 1.21-3.88) (P = 0.009). High NLR was also significantly associated with lack of response, OR 0.15 (95% CI: 0.04-0.51) (P = 0.002). Conclusion: In recurrent ovarian cancer patients undergoing palliative chemotherapy, low T and B lymphocyte counts had an unfavorable prognostic impact. High NLR was associated with lack of response and a poor prognosis, and the parameter may be used in patient counselling and treatment decisions.

show abstract

“…The combination of younger age, AVB, and nulliparity, as well as other characteristics, including obesity, in women with synchronous endometrioid/endometrial carcinomas suggests the involvement of a hormonal “field effect” in the development of these simultaneous tumors, particularly endometrioid cell-type tumors [ 14 , 19 ]. In recent years, accumulating evidence has suggested that ovarian cancer arises from the pleiotropic interactions of the committed stem cells within the ovary, the surrounding microenvironment, and the infiltrating immune cells [ 20 , 21 ]. Thus, whether these interactions may contribute to the development of synchronous endometrial and ovarian disorders needs further exploration.…”

Section: Discussionmentioning

confidence: 99%

Risk of synchronous endometrial disorders in women with endometrioid borderline tumors of the ovary

et al. 2018

View full text Add to dashboard Cite

BackgroundSynchronous endometrial disorders have been poorly studied in women with endometrioid borderline ovarian tumors (EBOT). The aims of this study were to investigate the risk of endometrial disorders among women with EBOT and associated factors, as well as their oncological and fertility outcomes.ResultsThis retrospective study included 33 women with EBOT. Their mean age was 41.9 years, and endometria were evaluated in 25 of these patients. The prevalence of synchronous endometrial disorders was 52.0% (n = 13/25) and this incidence was 41.4% (n = 46/111) after systematic analysis. Univariable analysis showed that EBOT patients who were younger, nulliparous, and had experienced abnormal vaginal bleeding were more likely to have synchronous endometrial disorders. The median follow-up was 54 months (range: 14-250 months), and three patients (10.3%) developed recurrences. No deaths due to EBOT were recorded. Among the nine nulliparous women treated conservatively who were attempting to conceive, only one (11.1%) pregnancy resulted in a live birth.ConclusionsSynchronous endometrial disorders are common in women with EBOT, especially in those who are younger, nulliparous, and have experienced abnormal vaginal bleeding. Thus, endometrial sampling should be performed in women with EBOT undergoing conservative surgery, and a hysterectomy should be performed in cases requiring radical treatment.

show abstract

Epithelial ovarian cancer inherent resistance: May the pleiotropic interaction between reduced immunosurveillance and drug-resistant cells play a key role?

Abstract: HighlightsCancer cells may have inherent chemoresistance which allows an indefinite expansion.Transformed ovarian epithelial cells may undergo an immunoediting process.Immunoedited ovarian cancer drug-resistant cells escape first-line chemotherapy.

Cited by 51 publications

References 8 publications

Preoperative serum levels of HE4 and CA125 predict primary optimal cytoreduction in advanced epithelial ovarian cancer: a preliminary model study

Preoperative serum levels of HE4 and CA125 predict primary optimal cytoreduction in advanced epithelial ovarian cancer: a preliminary model study

Prognostic significance of baseline T cells, B cells and neutrophil-lymphocyte ratio (NLR) in recurrent ovarian cancer treated with chemotherapy

Risk of synchronous endometrial disorders in women with endometrioid borderline tumors of the ovary

Contact Info

Product

Resources

About