Epithelial phosphate transport in ruminants, mechanisms and regulation

Shirazi-Beechey, Soraya P.; Penny, Jeffery I.; Dyer, Jane; Wood, I. Stuart; Tarpey, Patrick; Scott, D.; Buchan, William

doi:10.1038/ki.1996.142

Cited by 29 publications

(26 citation statements)

References 25 publications

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“…The order of magnitude of duodenal H ϩ -P i transport capacity (V max : 2.1 nmol ⅐ mg protein Ϫ1 ⅐ 10 s Ϫ1 ) as well as transporter affinity (K m : 0.4 mM) in goats correspond to those reported for sheep [V max : 3.6 nmol ⅐ mg protein Ϫ1 ⅐ 10 s Ϫ1 ; K m : 0.6 mM (13)]. Unlike in goats, in sheep, dietary P restriction (low-P diet) resulted in a higher duodenal P i transport capacity compared with control (high-P diet) (13). However, because P intake of the sheep was not precisely defined in that study, this discrepancy cannot be explained.…”

Section: P I Transport In the Duodenum Of Goatsmentioning

confidence: 67%

“…For sheep, H ϩ -P i transport in the upper small intestines has been described (13). This is in contrast to monogastric animals, in which duodenal P i transport has been identfied as a secondary active Na ϩ -coupled process (1).…”

Section: P I Transport In the Duodenum Of Goatsmentioning

confidence: 91%

“…In ruminants, the mechanism of intestinal P i transport is obviously more complex than in monogastric species. In the duodenum of sheep, an Na ϩ -independent, proton-driven P i transport has been described (13). Destruction of the inwardly directed H ϩ gradient into duodenal brushborder membrane vesicles (BBMV) inhibited P i uptake, suggesting the presence of an H ϩ -P i cotransport system.…”

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confidence: 99%

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Phosphate transport in the duodenum and jejunum of goats and its adaptation by dietary phosphate and calcium

Huber

Walter

Schröder

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

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Endogenous Pirecycling is a characteristic feature of the P homeostasis in ruminants. A pronounced salivary Pi secretion into the rumen is balanced by a high intestinal Pi absorption and an almost complete renal Pi reabsorption. In monogastric animals, the major Pi transport mechanism across the apical membrane of the enterocyte is an Na+-dependent transport mediated by NaPi cotransporter type IIb. In ruminants, an Na+-, as well as an H+-dependent, Pi transport system seems to exist in the small intestines. Therefore, morphological localization, type of ionic dependence, and ability to adapt to dietary P or Ca restriction of duodenal and jejunal Pi transport were characterized in goats. In the duodenum, there was an H+-dependent, Na+-sensitive Pi transport system that did not belong to the NaPi type II family and was not influenced by dietary P or Ca restriction. In contrast, in the jejunum, there was an Na+-dependent, H+-sensitive Pi transport mainly mediated by NaPi IIb. P restriction stimulated the NaPi IIb protein expression, resulting in higher Pi transport capacity.

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Section: P I Transport In the Duodenum Of Goatsmentioning

confidence: 67%

Section: P I Transport In the Duodenum Of Goatsmentioning

confidence: 91%

mentioning

confidence: 99%

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Phosphate transport in the duodenum and jejunum of goats and its adaptation by dietary phosphate and calcium

Huber

Walter

Schröder

et al. 2002

American Journal of Physiology-Regulatory, Integrative and Comp

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“…A similar value of apparent digestibility was obtained in the present study, when cows were supplied with the LP diet. Low dietary P increases the P absorption rate from the small intestine in ruminants (Horst, 1986;Shirazi-Beechey et al, 1996;Huber et al, 2002). It is possible that the LP cows adapted to the lower P supplementation by increasing the transport capacity in the small intestine (Huber et al, 2002).…”

Section: Discussionmentioning

confidence: 97%

Influence of low phosphorus intake during early lactation on apparent digestibility of phosphorus and bone metabolism in dairy cows

2006

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“…Furthermore, rumen microbes are able to digest phytic acid so that most of the phytate-bound P, the form of 0.35 and 0.70% of P in plants, is available for absorption in ruminants (Underwood and Suttle 2001). Low dietary P increases the P absorption rate or efficiency from the small intestine (Horst 1986;Shirazi-Beechey et al 1996;Huber et al 2002;Odongo et al 2002).…”

Section: Resultsmentioning

confidence: 99%

Long-term effects of feeding diets without mineral phosphorus supplementation on the performance and phosphorus excretion in high-yielding dairy cows

Odongo

McKnight²,

KoekKoek³

et al. 2007

Can. J. Anim. Sci.

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. W. 2007. Longterm effects of feeding diets without mineral phosphorus supplementation on the performance and phosphorus excretion in high-yielding dairy cows. Can. J. Anim. Sci. 87: 639-646. The objective of this study was to assess the long-term effects of feeding a diet with no mineral phosphorus (P) supplementation on performance and P excretion in high-yielding dairy cows. In exp. 1, 24 primiparous (PP) and 40 multiparous (MP) Holstein cows were allocated to one of two treatments at calving: (1) regular corn silage and alfalfa haylage based milking cow total mixed ration (TMR; 0.42% P diet) or (2) milking cow total mixed ration (TMR) without supplemental mineral P (0.35% P diet) in a completely randomized design. The trial lasted until after two lactations were completed or the cow was culled. In exp. 2, eight MP Holstein cows (108 ± 8.0 d in milk) were used to determine P digestibility and retention in a completely randomized block design. In exp. 1, the 0.35% P diet cows had lower body weight, body condition score and milk urea nitrogen and higher faecal P than the 0.42% P cows. The dry matter intake (DMI) of PP cows on the 0.35% P diet was lower than that of PP cows on the 0.42% P diet. There was no difference in the DMI of MP cows. The P intake of 0.35% P diet PP cows was 30% lower than that of 0.42% P diet PP cows. The P intake of 0.35% P diet MP cows was 20% lower than that of 0.42% P diet MP. The digestibility coefficient of P for the 0.35% P diet was higher than that for the 0.42% P diet. These results suggest that the forages used in the present study contained adequate amounts of P to sustain milk production in high-yielding MP cows. However, for PP cows some mineral P supplementation is recommended especially during early lactation.Key words: Phosphorus, environmental pollution, intensive dairy operations Odongo, N. E., McKnight, D., KoekKoek, A., Fisher, J. W., Sharpe, P., Kebreab, E., France, J. et McBride, B. W. 2007. Effets à long terme d'une alimentation sans supplément de phosphore minéral sur la performance des vaches laitières à rendement élevé et sur leur excrétion de phosphore. Can. J. Anim. Sci. 87: 639-646. L'étude devait évaluer les effets à long terme d'un régime non enrichi de phosphore minéral (P) sur la performance de grosses productrices de lait et sur l'excrétion de P par cellesci. Lors de la première expérience, les auteurs ont réparti entièrement au hasard 24 vaches Holstein primipares (PP) et 40 multipares (MP) entre deux traitements, au vêlage. Les traitements consistaient en 1) une ration mixte complète pour vache laitière à base d'ensilage ordinaire de maïs et de mi-fané de luzerne (TMR; régime à 0,42 % de P) ou 2) la TMR sans supplément de P minéral (régime à 0,35 % de P). L'essai a duré deux lactations ou jusqu'à la réforme de l'animal. Pour la deuxième expérience, huit vaches MP Holstein (108 ± 8,0 jours de lactation) réparties en bloc randomisé ont servi à déterminer la digestibilité et la réten-tion du P. Lors de la première expérience, les vaches recevant 0,35 % de...

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Epithelial phosphate transport in ruminants, mechanisms and regulation

Cited by 29 publications

References 25 publications

Phosphate transport in the duodenum and jejunum of goats and its adaptation by dietary phosphate and calcium

Phosphate transport in the duodenum and jejunum of goats and its adaptation by dietary phosphate and calcium

Influence of low phosphorus intake during early lactation on apparent digestibility of phosphorus and bone metabolism in dairy cows

Long-term effects of feeding diets without mineral phosphorus supplementation on the performance and phosphorus excretion in high-yielding dairy cows

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