Epithelial Tumors of the Ovary

Seidman, Jeffrey D.; Ronnett, Brigitte M.; Shih, Ie‐Ming; Cho, Kathleen R.; Kurman, Robert J.

doi:10.1007/978-1-4614-3165-7_14-3

Cited by 3 publications

(5 citation statements)

References 385 publications

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“…Epithelial ovarian tumors (EOTs) are the most common type of ovarian tumors, accounting for ∼60% of ovarian tumors and 85% of malignant ovarian tumors . Histologically, EOTs are classified into benign (57–60%), borderline (4–14%), and malignant (21–33%) . Borderline EOTs are histologically characterized as tumors with low malignant potential, mitotic activity, and nuclear atypia as well as without obvious invasion of the stroma .…”

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confidence: 99%

“…Histologically, EOTs are classified into benign (57–60%), borderline (4–14%), and malignant (21–33%) . Borderline EOTs are histologically characterized as tumors with low malignant potential, mitotic activity, and nuclear atypia as well as without obvious invasion of the stroma . It is important to differentiate between borderline and malignant EOTs prior to and during surgery because of the fertility‐sparing conservative surgery for the former and radical surgery for the latter .…”

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confidence: 99%

“…Different imaging techniques are available in the diagnosis of ovarian masses; however, only a few studies have focused on borderline tumors. In addition, due to the overlapping imaging appearances between borderline and malignant EOTs, borderline EOTs often represent a diagnostic challenge . In fact, a considerable portion of EOTs cannot be correctly diagnosed on conventional magnetic resonance imaging (MRI).…”

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Role of proton MR spectroscopy in the differentiation of borderline from malignant epithelial ovarian tumors: A preliminary study

Feng

Liu

et al. 2018

Magnetic Resonance Imaging

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Background Due to the overlapping imaging appearances between borderline and malignant epithelial ovarian tumors (EOTs), borderline EOTs often represent a diagnostic challenge on conventional MRI. Proton magnetic resonance spectroscopy (1H‐MRS) might have potential to differentiate borderline from malignant tumors. Purpose To investigate the ability of 1H‐MRS to differentiate borderline from malignant EOTs. Study Type Prospective. Population In all, 278 patients with adnexal masses. Field Strength/Sequence 1.5 T Siemens Avanto MRI system and 1H‐MRS using a point‐resolved spectroscopy sequence (PRESS). Assessment Resonance peak integrals of the most common metabolites were analyzed and compared between the two groups. Statistical Tests The ratios of metabolites between borderline and malignant EOTs were compared with the Mann–Whitney U‐test. A receiver operating characteristic (ROC) curve was used to determine their differential diagnosis performances. Results In the solid components of borderline and malignant EOTs, the mean Cho/Cr, NAA/Cr, and NAA/Cho ratios were 4.4 ± 1.1 and 9.9 ± 2.8; 10.4 ± 3.0 and 2.2 ± 1.0; and 2.4 ± 0.7 and 0.3 ± 0.1, respectively (all P < 0.001). The sensitivity, specificity, and area under the curve (AUC) were 91%, 100%, and 0.98 for the Cho/Cr ratio; 100%, 98%, and 0.99 for the NAA/Cr ratio; and 100%, 100%, and 1.00 for the NAA/Cho ratio, respectively. In the cystic components, the mean Cho/Cr, NAA/Cr, and NAA/Cho ratios were 3.2 ± 0.8 and 5.1 ± 1.2; 9.1 ± 3.4 and 2.3 ± 1.4; and 2.9 ± 1.2 and 0.5 ± 0.4, respectively (all P < 0.001). The sensitivity, specificity, and AUC were 84%, 82%, and 0.89 for the Cho/Cr ratio; 94%, 97%, and 0.99 for the NAA/Cr ratio; and 94%, 97%, and 0.99 for the NAA/Cho ratio, respectively. Data Conclusion The NAA/Cho ratio is a reliable biomarker for differentiating borderline from malignant EOTs. Level of Evidence: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;49:1684–1693.

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Role of proton MR spectroscopy in the differentiation of borderline from malignant epithelial ovarian tumors: A preliminary study

Feng

Liu

et al. 2018

Magnetic Resonance Imaging

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“…This theory is supported by the co-existence of Brenner tumor with mucinous cystadenoma and histological features of Brenner tumor. [ 8 ]…”

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confidence: 99%

Coexisting brenner tumor and endometrial carcinoma

Sharma¹,

Khangar²,

Mallya³

et al. 2017

J Mid-life Health

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Brenner tumor is a rare ovarian neoplasm that is seen in women of the fifth to sixth decade. Classified as benign, borderline, and malignant, these tumors may be associated with estrogen production, thus altering the estrogen–progesterone ratio. High estrogen stimulates the endometrium and this is responsible for producing various pathologies, namely, hyperplasia, atypia, and carcinoma. Very few case reports have been published highlighting the same. A case report is being presented here of a coexisting Brenner tumor and well-differentiated endometrial carcinoma in a 55-year-old nulliparous postmenopausal woman.

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“…Histologically they are characterized by atypical epithelial proliferation without stromal invasion ( Seidman et al, 2002 ). They account for 10–15% of all epithelial ovarian tumors.…”

Section: Introductionmentioning

confidence: 99%

Oncologic and reproductive outcomes of borderline ovarian tumors in Indian population

Kumari

Kumar

Bhatla

et al. 2021

Gynecologic Oncology Reports

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Highlights In BOT Fertility sparing surgery is a safe procedure in early stage disease and should be performed in a young patient. Recurrences are more common in the cystectomy group as compared to oophorectomy (33% vs 6.2%; p = 0.03). Overall and Recurrence free survival is favourable and recurrences are always salvaged by surgery. Spontaneous conception and live birth rates after fertility sparing surgery in patients with BOT are modest (50%).

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Epithelial Tumors of the Ovary

Cited by 3 publications

References 385 publications

Role of proton MR spectroscopy in the differentiation of borderline from malignant epithelial ovarian tumors: A preliminary study

Role of proton MR spectroscopy in the differentiation of borderline from malignant epithelial ovarian tumors: A preliminary study

Coexisting brenner tumor and endometrial carcinoma

Oncologic and reproductive outcomes of borderline ovarian tumors in Indian population

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