Epithelioid angiomyolipoma of the liver with striking giant cell component: Fine‐needle aspiration biopsy findings of a rare neoplasm

Alatassi, Houda; Sahoo, Sunati

doi:10.1002/dc.20979

Cited by 22 publications

(16 citation statements)

References 13 publications

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“…Previous literature showed most Epi-HAML tumors were completely devoid of adipose tissue, so little or no fatty attenuation or tense was observed on CT or MRI images, which is a characteristic radiographic features of Epi-HAML compared with that of typical HAML. However, the low fat content of Epi-HAML makes the diagnosis of these tumors difficult [1, 2, 4]. In our study, precontrast CT or MRI did not detect fatty attenuation in any of the tumors, a result consistent with previous reports.…”

Section: Discussionsupporting

confidence: 92%

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Epithelioid angiomyolipoma of the liver: CT and MRI features

Chen

Wang

et al. 2012

Abdom Imaging

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The purpose of our study was to retrospectively evaluate the computed tomography (CT)/magnetic resonance imaging features of epithelioid angiomyolipoma of the liver (Epi-HAML), with pathology as a reference. We reviewed the CT/MRI findings of six lesions of Epi-HAML and found absence of adipose tissue in the lesions. In addition, recognizing the imaging features of no capsule, and hypervasularity with central punctiform or filiform vessels as a characteristic enhancement may distinguish Epi-HAML from other hepatic tumors.

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Section: Discussionsupporting

confidence: 92%

“…However, there are atypical AMLs composed almost exclusively of epithelioid cells with pronounced abnormal blood vessels and with less or no lipocytes. These atypical AMLs have been referred to as Epi-AML [4]. The appearance of an Epi-AML has been reported in the kidney but rarely in the liver [5].…”

Section: Discussionmentioning

confidence: 99%

Epithelioid angiomyolipoma of the liver: CT and MRI features

Chen

Wang

et al. 2012

Abdom Imaging

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“…The liver is the second most common site of AML occurrence (1). Hepatic AML can present similarly to malignant tumors, such as hepatocellular carcinoma, both clinically and radiologically.…”

Section: Discussionmentioning

confidence: 99%

“…AMLs most frequently occur in the kidney, with the liver being the second most common site of involvement (1).…”

mentioning

confidence: 99%

Angiomyolipoma of the Liver: A Rare Benign Tumor Treated with a Laparoscopic Approach for the First Time

Damaskos

Garmpis

Garmpi

et al. 2017

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“…Angiomyolipoma: In hepatic angiomyolipoma, the haemorrhagic aspirates consist predominantly of epithelioid and/or spindle cells with increased vascularity but without obvious fat cells. The epithelioid variant is characterized by non‐cohesive sheets of epithelioid cells with thin cytoplasm, atypical nuclei and scattered bizarre, multinucleated forms 66 . Some larger cells have centrally condensed cytoplasm with peripheral vacuolation, bean‐shaped nucleus, distinct nucleolus and open chromatin.…”

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confidence: 99%

Fine needle aspiration biopsy of hepatocellular carcinoma and hepatocellular nodular lesions: role, controversies and approach to diagnosis

Wee

2011

Cytopathology

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The role of fine needle aspiration (FNA) biopsy of the liver has evolved. Advances in imaging modalities have obviated the need for tissue confirmation in clinically classic hepatocellular carcinoma (HCC). The risks of needle tract seeding and haematogenous dissemination have been actively debated. Nowadays, cytopathologists are confronted by smaller and smaller nodules, detected due to increased surveillance of high-risk cirrhotic patients. Tissue characterization of small well-differentiated hepatocellular nodular lesions (size less than and equal to 2 cm) is extremely challenging and has therapeutic implications. Major issues in the cytodiagnosis of HCC include: (i) distinguishing benign hepatocellular nodular lesions, namely, large regenerative nodules, dysplastic nodules, focal nodular hyperplasia and hepatocellular adenoma from reactive hepatocytes; (ii) distinguishing well-differentiated HCC from benign hepatocellular nodular lesions; (iii) distinguishing poorly differentiated HCC from intrahepatic cholangiocarcinoma and metastatic carcinomas; (iv) determining the histogenesis of a malignant tumour; and (v) determining the site of origin of a malignant tumour. An overview of the biological evolution and histopathological aspects of dysplastic nodules, small HCCs and 'nodule-in-nodule' lesions is presented in tandem with clinically relevant nomenclature. An algorithmic approach to FNA diagnosis of HCC and hepatocellular nodular lesions is outlined. Optimal results depend on (i) a dedicated radiologist-cytopathologist team; (ii) an on-site cytology service, (iii) a combined cytohistological approach, (iv) immunohistochemistry, and (v) clinicopathological correlation. As we move towards personalized medicine, it is envisaged that hepatic FNA is likely to become a point of care in the management protocol as it takes on the additional role of procurement of tumour and peritumoural tissues for genomic and proteomic profiling to enable targeted molecular therapy.

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Epithelioid angiomyolipoma of the liver with striking giant cell component: Fine‐needle aspiration biopsy findings of a rare neoplasm

Cited by 22 publications

References 13 publications

Epithelioid angiomyolipoma of the liver: CT and MRI features

Epithelioid angiomyolipoma of the liver: CT and MRI features

Angiomyolipoma of the Liver: A Rare Benign Tumor Treated with a Laparoscopic Approach for the First Time

Fine needle aspiration biopsy of hepatocellular carcinoma and hepatocellular nodular lesions: role, controversies and approach to diagnosis

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