Epithelioid hemangioendothelioma of the parotid salivary gland

Pigadas, N.; Mohamid, Waria; McDermott, Pedro Estrada

doi:10.1067/moe.2000.106299

Cited by 35 publications

(27 citation statements)

References 29 publications

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“…This tumor primarily committed to the soft tissues of the extremities (4), cases have been reported in lung, liver, bones, skin and the head and neck region, including the oral cavity (4)(5)(6). The EH is rare in the head and neck region and even more rare in the oral cavity, with 27 cases described from 1975 to 2008.…”

Section: Introductionmentioning

confidence: 99%

Intraoral epithelioid hemangioendothelioma: A case report and review of the literature

Gordon-Nunez¹,

Silva²,

Lopes³

et al. 2010

Med Oral

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The epithelioid hemangioendothelioma (EH) is an uncommon angiocentric neoplasm of borderline or intermediate malignant potential, between the hemangioma and conventional angiosarcoma. It is characterized by the proliferation of endothelial cells with epithelioid or histiocitóide morphology with vacuolated cytoplasm and occasional eosinophilic spindle cells. Shows potential for local recurrence as well as the ability to metastasize. Rarely affects the oral cavity, it have been described from 1975 until 2008 only 27 oral cases. Morphologically the EHs may be confused with other lesions, from a hemangioma to a squamous cell carcinoma, and thus immunohistochemical analysis is required. This paper reports the clinical and immunohistochemical characteristics of a case of EH in the gingiva of the tooth 35 of a 17 years-old-white-female. We present a review of the clinicopathological and immunohistochemical characteristics of the intraoral epithelioid hemangioendothelioma cases previously reported.

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Section: Introductionmentioning

confidence: 99%

Intraoral epithelioid hemangioendothelioma: A case report and review of the literature

Gordon-Nunez¹,

Silva²,

Lopes³

et al. 2010

Med Oral

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“…Immunohistochemical findings such as CD31, CD34 and F8 immunopositivity support the endothelial nature of Since 1982, EHE has been diagnosed in many other sites, such as larynx, oral cavity, heart, mediastinum, abdomen, parotid salivary gland, brain, nasal cavity, cutaneous structures, testis, lung, liver and bone [3,[6][7][8][9][10][11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 98%

Epithelioid hemangioendothelioma derived from the spine region: Case report and review of the literature

Gökhan

Akyuz

Gürer

et al. 2006

Wien Klin Wochenschr

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Epithelioid hemangioendotheliomas (EHE) are rare vascular tumors which generally originate from soft tissues and visceral organs. Primary bone EHEs, especially those occurring in the spine region, are extremely rare. Our case is that of a 30-year-old man who was admitted to hospital with low back pain, difficulty in walking, post-voiding urinary incontinence and numbness in the caudal area. X-ray showed a lytic process affecting the vertebra L2 and collapse of L1. Vertebrectomy of L1 and gross total tumor resection were performed. Histopathological and immunohistochemical findings of the tumor tissue supported the diagnosis of EHE. The case, which to the best of our knowledge is only the fifth such reported case, is presented with its clinicopathological findings and a review of the literature.

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“…Tumors were most frequently located in the soft tissue of the head and neck, gingiva and tongue. Other sites previously cited included buccal mucosa, parotid gland, nasal cavity, floor of mouth, larynx and thyroid [21][22][23][24][25][26][27]. Treatment was mainly local excision with only one case also treated by radiation.…”

Section: Discussionmentioning

confidence: 99%

“…Several examples at rare sites including the head and neck have previously been reported [13][14][15][16][17][18]. Regardless of origin, EHE may pose a diagnostic challenge due to the overlapping morphologic features with certain carcinomas, melanoma, and epithelioid sarcoma phenotypes [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. This diagnostic difficulty may further be compounded by occasional expression of cytokeratin in these tumors [12].…”

Section: Introductionmentioning

confidence: 95%

Epithelioid Hemangioendothelioma of the Head and Neck: Role of Podoplanin in the Differential Diagnosis

Naqvi

Ordóñez

Luna

et al. 2007

Head and Neck Pathol

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Epithelioid hemangioendothelioma is an uncommon vascular tumor of soft tissue and bone that may rarely occur in the liver, lung and the head and neck. We present five new cases of epithelioid hemangioendothelioma of the head and neck region diagnosed and managed in one institution in order to define the phenotypic characteristics, podoplanin immunohistochemical staining and the biological outcome. Podoplanin is a transmembrane mucoprotein selectively expressed in lymphatic endothelium and recently in some vascular neoplasms. The patients were comprised of two male and three female patients ranging in age from 4 to 71 years. The lesions were found in the gingiva, submandibular region soft tissue, nasal cavity and tongue, and ranged in size from 0.7 to 2.5 cm. All tumors manifested infiltrative cords and nests of epithelioid cells with occasional spindle morphology in a myxoid stroma. Immunohistochemical analysis of vascular and epithelial markers showed strong and uniform cytoplasmic reactivity for podoplanin and variable intensity and staining of CD31 and lack of cytokeratin staining in tumor cells. Surgical treatment included simple and wide local excisions. Of the three patients with follow-up, one developed lymph node metastasis and one had no evidence of disease 10 months after surgery. The patient with multiple recurrences and LN metastases was additionally treated with chemotherapy and is under consideration for radiation therapy. Hemangioendothelioma of the head and neck is: (1) a low-grade malignancy with a tendency for local recurrence and regional lymph node metastasis, (2) complete excision with negative margins is the treatment of choice for localized disease and (3) podoplanin may be useful in differentiating epithelioid hemangioendothelioma from non-vascular tumors.

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Epithelioid hemangioendothelioma of the parotid salivary gland

Cited by 35 publications

References 29 publications

Intraoral epithelioid hemangioendothelioma: A case report and review of the literature

Intraoral epithelioid hemangioendothelioma: A case report and review of the literature

Epithelioid hemangioendothelioma derived from the spine region: Case report and review of the literature

Epithelioid Hemangioendothelioma of the Head and Neck: Role of Podoplanin in the Differential Diagnosis

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