Epithelioid hemangioma in the oral mucosa: A case report

Henriques, Águida Cristina Gomes; Vidal, Manuela Torres Andion; Gurgel, Clarissa Araújo Silva; Rocha, Clarissa Araújo Gurgel; Carneiro, Bráulio; Almeida, de; Santos, Jean Nunes dos

doi:10.2298/sarh1610535h

Cited by 3 publications

(11 citation statements)

References 18 publications

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“…The endothelial cells are usually associated with a prominent inflammatory infiltrate consisting of dispersed lymphocytes, eosinophils, histiocytes and mast cells. [4] Epithelioid hemangioma in the oral mucosa is a rare disease and often confused with other epithelioid vascular tumours and nonvascular soft tissue tumours. In the literature various terms have been used by different authors to describe this lesion, including angioblastic hyperplasia with eosinophilia (ALHE), nodular angioblastic lymphoid hyperplasia with eosinophilia, lymphofolliculosis, histiocytoid hemangioma pseudopyogenic granuloma, and atypical pyogenic granuloma.…”

Section: Discussionmentioning

confidence: 99%

Clinical and hystopathological dilemmas in diagnosis of epitheloid hemangioma of maxillae-case report

2018

ijdrr

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Clinical and hystopathological dilemmas in diagnosis of epitheloid hemangioma of maxillae-case report Epithelioid hemangioma (EH) is a rare benign tumor involving the blood vessels and surrounding epithelioid cells. Epitheloid hemangioma, also called histiocytoid hemangioma, angiolymphoid hyperplasia with eosinophilia (ALHE), is a very rare benign tumor in maxillofacial region. There is a controversy in regards to correct diagnosis of an epithelioid hemangioma (EH), particularly when arising in skeletal locations, because of aggressive clinical characteristics, including multifocal presentation and occasional lymph node involvement. Specifically, its distinction from epithelioid hemangio-endothelioma (EHE) has been controversial. In literature we did not find a case where EH involves maxilla. However, there are few cases reported in which EH involved maxillary sinus and nasal cavity. We will present a case of 21 year old male, who came to our Department with a lesion in frontal maxillary region. He underwent surgery four times, wide excision, and with four different histopathology results. The last result was ephiteloid hemangioma with metaplastic bone formation-a very rare benign lesion in oral region, but clinically with very aggressive nature.

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Section: Discussionmentioning

confidence: 99%

Clinical and hystopathological dilemmas in diagnosis of epitheloid hemangioma of maxillae-case report

2018

ijdrr

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“…5,6 Extracutaneous lesions are uncommon, with reports involving muscles, bones, orbits, and oral mucosa. 3,[6][7][8][9][10][11][12][13][14] Cases of EH in the oral mucosa are rarely observed and, when they occur, seem to have a greater predilection for the male gender, especially young adults. The lips, tongue, buccal mucosa, and palate are the most commonly involved sites.…”

Section: Introductionmentioning

confidence: 99%

“…The lips, tongue, buccal mucosa, and palate are the most commonly involved sites. 12,13 The oral presentation of EH is non-specific, and the lesion can easily be confused with other lesions such as angioma, pyogenic granuloma, facial granuloma, insect bites, Kaposi's sarcoma, salivary gland tumor, lymphoma, lipoma, and squamous cell carcinoma. 3,6,12,13 The diagnosis is based on the lesion's clinical appearance and typical histopathological characteristics.…”

Section: Introductionmentioning

confidence: 99%

“…12,13 The oral presentation of EH is non-specific, and the lesion can easily be confused with other lesions such as angioma, pyogenic granuloma, facial granuloma, insect bites, Kaposi's sarcoma, salivary gland tumor, lymphoma, lipoma, and squamous cell carcinoma. 3,6,12,13 The diagnosis is based on the lesion's clinical appearance and typical histopathological characteristics. 6,12,15 Histologically, the lesion is composed of well-formed round or ovoid vessels covered by epithelioid endothelial cells with a histiocytoid appearance; the vessels are surrounded by an infiltrate of lymphocytes and eosinophils.…”

Section: Introductionmentioning

confidence: 99%

“…3,15,16 The immuno-histochemistry of oral EH's epithelioid endothelial cells is commonly immunoreactive for CD34 and antigen associated with factor VIII. 3,6,[11][12][13][14] The treatment of EH is performed through surgical excision. Although recurrence may be observed in one-third of cases of cutaneous EH, 17 it is quite infrequent in the cases of the oral mucosa.…”

Section: Introductionmentioning

confidence: 99%

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Epithelioid hemangioma in the oral cavity: Report of a rare case

Assis¹,

Mattos²,

Milani³

2022

j.rpemd

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The epithelioid hemangioma (EH), also known as angiolymphoid hyperplasia with eosinophilia, is a benign, neoplastic vascular tumor rarely presented in the mouth. It is most frequent in young adult male patients. Clinically, it is characterized by papules or nodules, usually with a reddish-brown color, mimicking other vascular and non-vascular lesions. Histologically, the lesion is composed of well-formed round vessels with epithelioid endothelial cells, with a histiocytoid appearance, surrounded by an infiltrate of lymphocytes and eosinophils. Oral EH’s endothelial cells are commonly immunoreactive for CD34 and factor VIII antigen. Surgical excision is the most widely used form of treatment, and recurrences are uncommon. The aim of this study was to report a rare case of oral EH in a 52-year-old female patient.

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Epithelioid Hemangioma Masquerading as Traumatic Lesion: A Rare Case Report with Diagnostic Workup

Grover,

Jain,

Gulati

et al. 2024

Journal of Microscopy and Ultrastructure

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Wells and Whemser first identified epithelioid hemangioma (EH) as angiolymphoid hyperplasia in 1969. It is a rare type of vascular tumor that primarily affects men in their middle ages. Typically, it appears as a single or few reddish-to-brown nodules. EHs of the oral cavity have only seldom been reported up to this point. Histologically, it is distinguished by lobular vessel configuration, tombstone-like epithelioid cells lining the vessel wall, and a persistent inflammatory infiltration predominately made up of eosinophils. Although the terms EH and epithelioid hemangioendothelioma are sometimes confused, the two are distinct based on histopathology and a number of immunohistochemistry (IHC) markers, including high Ki67 index and ERG positivity observed later. Local trauma to a nearby vessel may be one of the etiopathogeneses for this entity. This is a rare case report of EH that was identified with the use of a panel of IHC markers and hematoxylin and eosin histology.

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Epithelioid hemangioma in the oral mucosa: A case report

Cited by 3 publications

References 18 publications

Clinical and hystopathological dilemmas in diagnosis of epitheloid hemangioma of maxillae-case report

Clinical and hystopathological dilemmas in diagnosis of epitheloid hemangioma of maxillae-case report

Epithelioid hemangioma in the oral cavity: Report of a rare case

Epithelioid Hemangioma Masquerading as Traumatic Lesion: A Rare Case Report with Diagnostic Workup

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