Epithelioid sarcoma: a tumour of myofibroblasts

Blewitt, R W; Aparicio, S. R.; Bird, C. C.

doi:10.1111/j.1365-2559.1983.tb02269.x

Cited by 33 publications

(10 citation statements)

References 21 publications

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“…[87][88][89] This occurs mainly toward the edges of the tumor nodules by apparent transition from epithelioid cells and is associated with expression of smooth muscle and muscle-specific actins but not desmin. 90 Similar myofibroblast-like differentiation is also seen in spindle cells of sarcomatoid carcinoma.…”

Section: Myofibroblast-like Differentiation In Malignant Tumors With mentioning

confidence: 99%

Myofibroblastic Malignancies

Fisher¹

2004

Advances in Anatomic Pathology

116

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Malignant tumors composed of myofibroblasts are increasingly being recognized, but their existence remains controversial. Currently accepted examples within this category represent spindle cell or pleomorphic neoplasms of the soft tissues with a spectrum of histological grades. Low- and intermediate-grade myofibrosarcomas are fascicular spindle cell neoplasms resembling fibrosarcoma or leiomyosarcoma. They infiltrate deep soft tissue with disproportionate involvement of head and neck sites and can recur locally but infrequently metastasize. They variably express myoid immunohistochemical markers, and their differential diagnosis includes benign myofibroblastic proliferations such as fasciitis and fibromatosis as well as other types of spindle cell sarcoma. High-grade (pleomorphic) myofibrosarcomas are an ultrastructurally defined subset of malignant fibrous histiocytoma, which they resemble in morphology and behavior. Inflammatory myofibroblastic tumor and infantile fibrosarcoma are neoplasms that have myofibroblastic features and have been included in this category, but they have distinctive genetic findings. This article reviews the concept of myofibrosarcoma and describes its variants.

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Section: Myofibroblast-like Differentiation In Malignant Tumors With mentioning

confidence: 99%

Myofibroblastic Malignancies

Fisher¹

2004

Advances in Anatomic Pathology

116

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“…In addition, myofibroblastic differentiation has been observed in tumours showing predominantly epithelial differentiation, notably epithelioid sarcoma [5,29,33] and sarcomatoid carcinomas [1]. In both, there appears to be progression or transition from cells with epithelioid features to those of myofibroblasts, with immunophenotypical and ultrastructural changes accompanying the change in cell shape.…”

Section: Other Sarcomas Of Myofibroblastsmentioning

confidence: 99%

Myofibrosarcoma

Fisher

2004

Virchows Arch

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Myofibrosarcomas are malignant tumours of myofibroblasts, which have been recognised for many years, but have become clearly defined only recently. They are low- or high-grade sarcomas that arise in soft tissue or bone in adults or children. Low-grade myofibrosarcomas are infiltrative tumours, usually in deep soft tissue, with a predilection for the head and neck region, which display a range of microscopic appearances from fasciitis-like to fibrosarcoma-like; all cases at least focally display nuclear pleomorphism. They express smooth-muscle actin and calponin, and some express desmin, but most lack h-caldesmon. Low-grade myofibrosarcomas can recur but rarely metastasise. Their differential diagnosis is from benign myofibroblastic proliferations, such as fasciitis and fibromatosis, as well as from fibrosarcoma and leiomyosarcoma. Pleomorphic myofibrosarcomas are high-grade pleomorphic sarcomas (malignant fibrous histiocytoma), which show ultrastructural evidence of myofibroblastic differentiation. They closely resemble malignant fibrous histiocytoma clinically and morphologically, but are more frequently actin positive. This article describes the low- and high-grade variants of myofibrosarcoma and other malignant tumours with myofibroblastic differentiation.

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“…The tumour tends to spread along connective tissue planes, or grow along neurovascular bundles. The exact histogenesis ofthe tumour remains uncertain (Cooney, 1982;Blewitt, Apavicio & Bird, 1983). A mesenchymal origin seems compatible with the ultrastructural features (Bloustein, Silverberg & Waddell, 1976).…”

Section: Discussionmentioning

confidence: 98%

Epithelioid sarcoma-a case report

et al. 1986

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Summary A case of epithelioid sarcoma of the thumb is reported and the problems of diagnosis and management considered. Epithelioid sarcoma is a rare tumour which was first recognized as a distinct entity by Enzinger in 1970. It is frequently mistaken by clinicians and pathologists for a variety of benign and malignant processes, especially chronic inflammatory disorders, synovial sarcoma and ulcerating squamous cell carcinoma. Young adults are mainly affected; the principal tumour sites are the fingers, hands and forearm. The tumour is often superficial, affecting dermis or subcutis.

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Epithelioid sarcoma: a tumour of myofibroblasts

Cited by 33 publications

References 21 publications

Myofibroblastic Malignancies

Myofibroblastic Malignancies

Myofibrosarcoma

Epithelioid sarcoma-a case report

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