Epithelioid trophoblastic tumor: a case report

Lo, Christine; Low, Ivan Cherh Chiet; Tan, Alvin; Baranyai, Judith

doi:10.1111/j.1525-1438.2006.00609.x

Cited by 13 publications

(5 citation statements)

References 7 publications

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“… 8 Lo et al reported a 9-cm ETT extending to the right pelvic side wall, with an extensive area containing necrotic matter. 9 Liang et al, Noh et al, and Fadare et al have reported four cases of large cystic lesions containing hemorrhagic material and necrosis, as in this case, and some of their cases had fistulas in the uterine cavity. 6 , 10 , 11 In the present case, the fistula was narrow and was associated with no inflammation or foreign body reaction along its length; an inflow of menstrual blood through it was therefore considered unlikely.…”

Section: Discussionmentioning

confidence: 51%

MR Imaging of Uterine Epithelioid Trophoblastic Tumor: A Case Report

Kageyama

Kanoto

Sugai

et al. 2016

MRMS

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Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic neoplasm of chorionic-type intermediate trophoblasts, and it is most frequently located in the lower uterine segment and endocervix. Due to the epithelial-growth pattern with geographic necrosis exhibited by the neoplastic cells, ETT is commonly confused, both clinically and pathologically, with squamous cell carcinoma. Although there have been no previous reports of ETT focusing on computed tomography (CT) or magnetic resonance imaging (MRI) findings, we report a case of uterine ETT with special attention to the MRI findings referring to the pathological findings and MR images of previous reports. A 42-year-old Japanese woman (gravid 1, para 1) presented with uterus enlargement during screening, and complained of recent-onset lower abdominal pain. The MRI showed a solid tumor throughout the entire myometrium of the lower uterine segment, with the hemorrhagic cystic portion extending to the posterior subserosal space. Following hysterectomy, the final pathological diagnosis was ETT. An ETT is essentially a solid tumor composed of intermediate trophoblasts that exhibit an epithelial-like growth pattern and contain geographic necrosis with calcification. In our case, MRI revealed a non-specific-intensity solid tumor in the lower uterine segment with massive necrosis and hemorrhage extending to the subserosa. While it is difficult to distinguish between ETT and uterine carcinomas, recognition of certain tumor shapes and necrosis could enable more accurate diagnosis before treatment.

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Section: Discussionmentioning

confidence: 51%

MR Imaging of Uterine Epithelioid Trophoblastic Tumor: A Case Report

Kageyama

Kanoto

Sugai

et al. 2016

MRMS

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“…The well-circumscribed, nodular growth pattern of ETT is not seen in CC. The hyaline like matrix and necrosis present in ETT can resemble keratin and has reportedly lead to the misdiagnosis of cervical squamous cell carcinoma (SCC) [12–16]. In addition to keratin, SCC is further marked by the presence of keratin pearls and intercellular bridges [13].…”

Section: Discussionmentioning

confidence: 99%

Epithelioid Trophoblastic Tumor: A Case Report and Review of the Literature

Scott

Smith

Desouki

et al. 2012

Case Reports in Obstetrics and Gynecology

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Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic tumor. Cases of ETT present as abnormal vaginal bleeding in women of reproductive age, with low human chorionic gonadotropin (hCG) levels. ETT can be a sequela of any gestational event and can present in both intrauterine and extrauterine sites. Metastasis and death have been reported. We present a case of a 44-year-old female incidentally diagnosed with ETT following laparoscopic-assisted vaginal hysterectomy. Postoperative evaluation for metastatic disease was negative. The patient has been closely followed and remains disease free 8 months postoperatively. ETT presents a diagnostic challenge due to its rarity and histologic resemblance to other pathologies. ETT is relatively chemoresistant and managed surgically. Misdiagnosis delays effective treatment and affects survival.

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“…Most reported cases of epithelioid trophoblastic tumor have solitary nodules with a sharp tumor border growing in an expansive fashion, invading the cervix or myometrium deeply, which is consistent with our ultrasound findings (Figure 2). In contrast, placental‐site trophoblastic tumor shows infiltrating growth penetrating between muscle fibers8–11. Ultrasonography may be helpful for differentiating between these two types of tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Generally the behavior of epithelioid trophoblastic tumor is similar to that of placental‐site trophoblastic tumor, and both of them usually behave in a benign fashion, but metastasis and death occur in about 25% and 10% of cases, respectively3. Epithelioid trophoblastic tumor, like placental‐site trophoblastic tumor, may be unresponsive to the chemotherapeutic agents used in the treatment of other types of gestational trophoblastic disease and the recommended primary treatment is surgical intervention8, 11, 12.…”

Section: Discussionmentioning

confidence: 99%