Epithelioid trophoblastic tumor of paracervix and parametrium

Noh, H.T.; Lee, Kap Ho; Lee, M.A.; Ko, Young Bok; Hwang, Soo Hyun; Son, SungKyong

doi:10.1111/j.1525-1438.2007.01086.x

Cited by 21 publications

(23 citation statements)

References 8 publications

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“…All previously reported extrauterine ETT included lung, vagina, broad ligament, fallopian tube, gallbladder, paracervix and parametrium, probably originating from uterine trophoblastic disease [6][7][8][9][10][11][12]. Pancreas metastasis in our study, to our knowledge, was the first case reported.…”

Section: Discussionmentioning

confidence: 39%

Epithelioid trophoblastic tumor: a clinicopathological and immunohistochemical study of seven cases

Shi

Wan

et al. 2010

Med Oncol

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The objective of this study is to evaluate the clinicopathological features and immunohistochemical characteristics of epithelioid trophoblastic tumor (ETT). Seven cases of epithelioid trophoblastic tumor treated in the Women's Hospital of Zhejiang University from 2004 September to 2008 December were retrospectively analyzed. Immunohistochemical study was performed. The most common presenting symptom was vaginal bleeding. Four patients had prior evidence of molar pregnancy and three patients presented with metastases. Mean age at diagnosis was 34.7 years. Mean pregnancy interval was 3.39 years. Human chorionic gonadotropin levels were 33.25-174315.5 IU/l. One case died from metastasis in lungs. The remaining six patients survived without recurrence. Immunohistochemistry revealed diffusely positive for CK18, and focally positive for β-hCG, HPL, Mel-CAM (CD146) and inhibin-alpha. Nuclear staining of Ki67 and p63 were seen. The confirmation of epithelioid trophoblastic tumor diagnosis is difficult before surgery. Surgical intervention is the recommended primary treatment.

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Section: Discussionmentioning

confidence: 39%

Epithelioid trophoblastic tumor: a clinicopathological and immunohistochemical study of seven cases

Shi

Wan

et al. 2010

Med Oncol

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“…The interval between prior gestation or gestational trophoblastic tumor and ETT can range from 2 weeks to 30 years [8,9]. Extrauterine ETT in the absence of a uterine tumor has been documented in the lung, parametrial tissue, broad ligament, liver, spine, orbit and lymph nodes [8,9,10,11,12,13,14]. …”

Section: Discussionmentioning

confidence: 99%

Epithelioid Trophoblastic Tumor: Report of Two Cases in Postmenopausal Women with Literature Review and Emphasis on Cytological Findings

Almarzooqi

Al-Safi²,

Al-Jassar³

et al. 2014

Acta Cytologica

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Background: Epithelioid trophoblastic tumor (ETT) is a rare gestational trophoblastic neoplasm of intermediate trophoblasts. It was first described by Shih and Kurman [Am J Surg Pathol 1998;22:1393-1403] who outlined its clinicopathologic characteristics in 14 cases, establishing it as a distinct entity of gestational trophoblastic tumors. It represents 1.39% of all gestational trophoblastic diseases. Most cases are reported in reproductive-age women following a prior gestation with a time interval between 2 weeks and 30 years. ETT is extremely rare in postmenopausal women. It is commonly misdiagnosed as a squamous cell carcinoma (SCC), poorly differentiated carcinoma or another gestational trophoblastic tumor. Limited data is available regarding its cytological features on Pap smears. Cases: We report 2 cases of uterine ETT occurring in postmenopausal women. In both cases, an initial diagnosis of an SCC and a poorly differentiated carcinoma was rendered. We highlight the features of ETT helpful in differentiating it from other mimickers with emphasis on rarely reported cytological features of this neoplasm. Conclusion: ETT is a rare tumor with characteristic cytological features, but is commonly confused with SCC. A high index of suspicion is needed to make the correct diagnosis or to raise the consideration of ETT, especially in cases with an increased β-human chorionic gonadotropin.

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“…Most cases present in reproductive-age women with a prior gestation. The most common presenting symptom is abnormal uterine bleeding (Noh et al, 2008;Vencken et al, 2006;Palmer et al, 2008). This case posed a diagnostic challenge because of its unusual presenting characteristics.…”

Section: Discussionmentioning

confidence: 96%

“…Epithelioid trophoblastic tumor (ETT) is an uncommon gestational trophoblastic tumor (Noh et al, 2008) which often presents as a discrete uterine mass following pregnancy with vaginal bleeding (Noh et al, 2008;Vencken et al, 2006). Here we report our experience in managing a nulligravid woman with an unusual presentation of this rare tumor type.…”

Section: Introductionmentioning

confidence: 92%