EPR analysis of gamma irradiated single crystal cimetidine

Sayin, Ulku

doi:10.1016/j.molstruc.2012.07.022

Cited by 9 publications

(2 citation statements)

References 47 publications

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“…The g and linewidth values of the single signal were calculated as g=2.0047 and ∆H=20 G, respectively. When the literature is examined, it is seen that EPR spectroscopy is frequently used in examining irradiated food and amino acid compounds as well as irradiated drugs (Desrosiers, 1996;Kasumov et al, 2001, Aydın et al, 2008Aydın et al, 2009;Başkan et al, 2010;Sayın, 2013, Başkan et al, 2015Zhang, 2015;Sezer et al,2017, Tokatlı et al, 2018, Karakaş et al, 2018. In this study, it was aimed to determine the chemical structures of the free radicals formed after gamma irradiation of CLP and PAH samples, which have such important properties in medicine.…”

Section: Introductionmentioning

confidence: 99%

Gama ile Işınlanmış Klorpropamid ve Prokainamid Hidroklorür İlaç Hammaddelerinde Oluşan Serbest Radikallerin EPR Spektroskopisi ile Tanımlanması

SÜTÇÜ,

OSMANOĞLU

2023

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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In this study, it was aimed to determine the structural properties of free radicals formed by gamma irradiation in chlorpropamide and procainamide hydrochloride drug raw materials, which are widely used in medicine, by using electron paramagnetic resonance spectroscopy. As a result of gamma irradiation, it was determined that two different radicals were formed in both chlorpropamide and procainamide hydrochloride samples. It was suggested that –NĊH-, -NCH2ĊH2- and –NĊH-, -NĊHCH2- radicals were formed in chlorpropamide and procainamide hydrochloride samples, respectively. The simulated spectra closest to the experimental spectra recorded at room temperature of the samples studied in powder form were obtained using simulation software. The contributions of the proposed radicals to the experimental spectra were calculated. The g values of the obtained radicals and the hyperfine structure constants of the unpaired electrons were calculated.

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Section: Introductionmentioning

confidence: 99%

Gama ile Işınlanmış Klorpropamid ve Prokainamid Hidroklorür İlaç Hammaddelerinde Oluşan Serbest Radikallerin EPR Spektroskopisi ile Tanımlanması

SÜTÇÜ,

OSMANOĞLU

2023

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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“…Cimetidine is an H 2 -blocker drug from gastric parietal cells used to treat dyspepsia, gastric and duodenal ulcers, which not only inhibits the stimulating effects of histamine on gastric acid secretion, but also the actions of all other gastric stimulants (Saiyn 2012;Cotton et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Associative administration of cimetidine and exogenous melatonin on the endometrial receptors of estrogen, collagen and hormone levels in adult rats

Silva¹,

Elias

Silva³

et al. 2020

PECEN

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Cloridrato de cimetidina, um bloqueador de receptores H2 das células parietais gástricas, que age reduzindo a secreção de ácido no estômago e tem sido estudado como substância xenoestrogênica. O uso crônico da cimetidina produz distúrbios homonais e toxidade no aparelho reprodutor masculino, além de reduzir o estradiol 2-hidroxilado e aumentar níveis séricos de estradiol e prolactina em mulheres, levando a hiperprolactinemia, que pode ser fator de risco para o câncer. A melatonina, neurohormônio sintetizado pela glândula pineal tem importante papel na função reprodutiva, regulando a produção de estrógeno, progesterrona e prolactina. O estudo testou a hipótese de que a melatonina pode bloquear ou reduzir os efeitos estrogênicos da cimetidina no estroma uterino, interferindo nos receptores de estrógeno, no teor de fibras colágenas e nos níveis hormonais em ratas adultas. Quarenta e cinco (45) ratas albinas divididas em três grupos: I – tratadas com placebo (controle); II – tratado com cimetidina (50 mg/kg) e III – tratado com cimetidina (50 mg/kg) associada à melatonina (200 μg/100 g). Os experimentos foram conduzidos por 7, 14 e 19 dias. Nos grupos tratados apenas com cimetidina, observou-se marcações mais intensas dos receptores REα, maior distribuição das fibras colágenas no endométrio, elevação dos níveis séricos de estrogênio, prolactina e redução da progesterona, nos animais tratados por 19 dias. Na associação cimetidina e melatonina, acredita-se que a melatonina bloqueou esses efeitos. A melatonina tem atividade citoprotetora para efeitos crônicos da cimetidina no estroma endometrial, por reduzir ou prevenir o aumento da síntese de fibras de colágeno pelos fibroblastos regulando a atividade do estrogênio sérico, bem como a expressão de seus receptores endometriais, além de manter os níveis normais de progesterona e prolactina.Palavras chave: Melatonina, receptor de estrógeno, xenoestrógeno, morfometria, níveis hormonais.

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ESR of Irradiated Drugs and Excipients for Drug Control and Safety

Iravani

2017

Electron Spin Resonance in Food Science

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EPR analysis of gamma irradiated single crystal cimetidine

Cited by 9 publications

References 47 publications

Gama ile Işınlanmış Klorpropamid ve Prokainamid Hidroklorür İlaç Hammaddelerinde Oluşan Serbest Radikallerin EPR Spektroskopisi ile Tanımlanması

Gama ile Işınlanmış Klorpropamid ve Prokainamid Hidroklorür İlaç Hammaddelerinde Oluşan Serbest Radikallerin EPR Spektroskopisi ile Tanımlanması

Associative administration of cimetidine and exogenous melatonin on the endometrial receptors of estrogen, collagen and hormone levels in adult rats

ESR of Irradiated Drugs and Excipients for Drug Control and Safety

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