EPR and FT-IR spectroscopic studies of l-lysine monohydrochloride and l-glutamic acid hydrochloride powders

Aydin, Murat; Kartal, Zeki; Osmanoğlu, Şemsettin; Başkan, M. Halim; Topkaya, R.

doi:10.1016/j.molstruc.2011.03.010

Cited by 31 publications

(16 citation statements)

References 32 publications

(29 reference statements)

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“…At 300 °C, the TG curve showed the beginning of the degradation of the PCV. The DSC curve of LYS (Figure 2) showed an endothermic peak at 261 °C, which corresponded to its melting temperature and degradation (as observed in the TG curve), which agreed with a previous study [32]. A mass loss of 1.66% at about 70 °C was observed due to the loss of water.…”

Section: Resultssupporting

confidence: 90%

Solid-State Characterization and Compatibility Studies of Penciclovir, Lysine Hydrochloride, and Pharmaceutical Excipients

et al. 2019

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The physical and chemical characterization of the solid-state properties of drugs and excipients is fundamental for planning new formulations and developing new strategies for the treatment of diseases. Techniques such as differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy are among the most commonly used techniques for these purposes. Penciclovir and lysine are individually used to treat the herpes virus. As such, the development of a formulation containing both drugs may have therapeutic potential. Solid-state characterization showed that both penciclovir and lysine were crystalline materials with melting points at 278.27 °C and 260.91 °C, respectively. Compatibility studies of penciclovir and lysine indicated a possible interaction between these substances, as evidenced by a single melting point at 253.10 °C. The compatibility of several excipients, including ethylenediaminetetraacetic acid, cetostearyl alcohol, sodium lauryl sulphate, di-tert-butyl methyl phenol, liquid petrolatum, methylparaben, nonionic wax, paraffin, propylene glycol, and propylparaben, was evaluated in ternary (penciclovir-lysine-excipient) mixtures (1:1:1, w/w/w) to determine the optimal formulation. The developed formulation was stable under accelerated and ambient conditions, which demonstrated that the interaction between penciclovir and lysine was suitable for the development of a formulation containing both drugs.

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Section: Resultssupporting

confidence: 90%

Solid-State Characterization and Compatibility Studies of Penciclovir, Lysine Hydrochloride, and Pharmaceutical Excipients

et al. 2019

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“…The radical produced in LG was also observed in γ -irradiated single crystals of 2,2-dimethyl succinic acid and l-lysine monohydrochloride at room temperature. The reported average values a CH = 2.7 mT, a CH2 = 1 mT, and a CH = 2.03 mT, a 1 CH2 = 3.66 mT, a 2 CH2 = 2.54 mT agree with our results (19,20). The simulation of the spectrum with the given values is shown in Figure 3(b).…”

Section: Resultssupporting

confidence: 88%

“…When the magnetic field is along the a axis, the NCH 2Ċ H radical indicates only that the unpaired electron is interacted with nitrogen nucleus. The hyperfine coupling constant for the 14 The characterization of the radical is found by comparing the simulated and experimental spectra, and by addition of the derived hyperfine splittings with those obtained in similar radicals (17,19,20). The experimental and simulated EPR spectra were found to be in agreement well with each other, as shown in Figure 1(a) and 1(b).…”

Section: Resultssupporting

confidence: 58%

“…The experimental and simulated EPR spectra are found to agree well with each other. A spectrum with similar features and the same hyperfine splittings was observed in the single crystals of 2,2-dimethyl succinic acid, and l-lysine monohydrochloride (19,20). Analysis of these interactions was discussed in the LG and shown mainly to be due to hyperfine coupling in radical.…”

Section: Resultsmentioning

confidence: 57%

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Electron paramagnetic resonance study of free radicals in γ-irradiated L-glutamine and L-glutamine-t-butyl ester hydrochloride

Dicle

Osmanğolu

İpek

2015

Radiation Effects and Defects in Solids

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Electron paramagnetic resonance (EPR) spectra of γ -irradiated single crystals of l-glutamine (LG) and l-glutamine-t-butyl ester hydrochloride (LGBESHCI) powders were studied and analyzed for different orientations of the crystals in the magnetic field, after γ -irradiation. The spectra were observed to be independent of temperature down to 130 K. The hyperfine interaction tensors for one α proton and two β protons of radical have been determined at 295 K. An analysis of the EPR of γ -irradiated single crystals of LG and LGBESHCI powders shows that the paramagnetic species produced by the radiation damage is CH 2Ċ H. The g values of the radical and the hyperfine structure constants of the free electron with nearby protons and 14 N nucleus were determined. The results were found to be in good agreement with the existing literature data.

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“…90; 116 No espectro da lisina estão presentes bandas em 1580 cm -1 referente a deformação assimétrica dos grupos -NH2 e em 1508 cm -1 referente a deformação simétrica dos grupos -NH2. 118 O desaparecimento deste último é um indício da formação do entrecruzamento entre as duas cadeias poliméricas…”

Section: Hidrogéis De Goma Gelana E Jeffaminaunclassified

Redes poliméricas de macromoléculas naturais como hidrogéis superabsorventes

Sabadini¹

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New hydrogels based on natural macromolecules such as gellan gum, chitosan, alginate, gelatin and lysine were synthetized and characterized by spectroscopic, thermal and microscopic analysis. The samples were also investigated in terms of water absorption and fertilizers release. The samples were obtained by crosslinking reactions of gellan gum (GGHA and GGLA) with (i) chitosan ( For the sample GGHA:CH the water retention time was 100% higher and about 60% higher for the hydrogels GGHA:LYS, GGHA:JEF and GGHA:GEL. The samples were charged with commercial fertilizers such as phosphate monopotassium (MKP) and phosphate monopotassium (MKP), and they were tested as controlled fertilizer release materials for agriculture. It was observed for all samples that a complete release of MKP occurred after 8 h of its immersion in water and was estimated in about 400 mg per one gram of polymer. The controlled release of NPK was in about 300 mg per one gram of hydrogel, independent of the hydrogel composition. In conclusion, all the obtained results revealed that the natural macromolecules-based hydrogels are very promising alternatives for humidity control system and controlled fertilizers release in agriculture.

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EPR and FT-IR spectroscopic studies of l-lysine monohydrochloride and l-glutamic acid hydrochloride powders

Cited by 31 publications

References 32 publications

Solid-State Characterization and Compatibility Studies of Penciclovir, Lysine Hydrochloride, and Pharmaceutical Excipients

Solid-State Characterization and Compatibility Studies of Penciclovir, Lysine Hydrochloride, and Pharmaceutical Excipients

Electron paramagnetic resonance study of free radicals in γ-irradiated L-glutamine and L-glutamine-t-butyl ester hydrochloride

Redes poliméricas de macromoléculas naturais como hidrogéis superabsorventes

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