EPR study of free radicals in some drugs γ-irradiated in the solid state

Ambroż, Hanna B.; Kornacka, Ewa; Marciniec, B; Ogrodowczyk, Magdalena; Przybytniak, G.

doi:10.1016/s0969-806x(99)00489-2

Cited by 47 publications

(23 citation statements)

References 9 publications

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“…The determined EPR values for the ring type radical agree with the values found by other research for similar ring radicals that have 14 N atoms [45][46][47][48][49][50][51][52][53]. The spectra of the Right Part are similar to the spectra of ring radicals obtained from gamma-irradiated 4-phenylsemicarbazide [52] and alpha-benzoinoxime [53] in previously published studies.…”

Section: Resultssupporting

confidence: 88%

EPR analysis of gamma irradiated single crystal cimetidine

Sayin

2013

Journal of Molecular Structure

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Section: Resultssupporting

confidence: 88%

EPR analysis of gamma irradiated single crystal cimetidine

Sayin

2013

Journal of Molecular Structure

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“…In this context, it is important to find methods distinguishing between unirradiated and irradiated drugs and foods. Electron Paramagnetic Resonance (EPR) spectroscopy is one of the leading methods used to identify foods and drugs [7,8].…”

Section: Introductionmentioning

confidence: 99%

Study of dose-response and radical decay curves of gamma irradiated norfloxacin using EPR spectroscopy

Sütçü¹,

Osmanoğlu²

2017

AIP Conference Proceedings

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In this study, Electron Paramagnetic Resonance (EPR) spectra of unirradiated and γ-irradiated at doses of 1, 5, 10, 12 and 15 kGy norfloxacin (NOF) were investigated. Before irradiation no EPR signal were observed. After irradiation a weak singlet signal at g = 2.0039 were obtained at room temperature. In order to describe the variation of EPR signal intensity with absorbed radiation dose, several mathematical equations were tried. Increasing irradiation dose up to 15 kGy has increased the signal intensity of the central signal however, no significant changes were observed in g spectroscopic splitting factor. The stability of signal intensity of irradiated NOF was studied over a storage period of 200 days. According to analyses conducted, EPR spectroscopy can be used to distinguish irradiated and unirradiated samples from each other.

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“…It can be used for studying the radiolysis mechanism or for the detection of irradiated amino acids and drugs where unpaired electron is included. (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) Besides, this technique has also been applied to irradiated foodstuffs and for the detection of free radicals produced by an irradiation treatment in the meat containing bone. (18)(19)(20)(21)(22)(23) The aim of this work is to study behaviors and the hyperfine structure of free radicals formed in N-methyl-dl-alanine (NMA), N,N-dimethyl glycine hydrochloride (DMGH), and D -( + ) -galactosamine hydrochloride (DG) amino acid derivatives by gamma radiation at room temperature.…”

Section: Introductionmentioning

confidence: 99%

The effect of gamma radiation of amino acid derivatives in the solid state: an EPR study

Dicle¹,

Osmanoğlu²

2014

Radiation Effects and Defects in Solids

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The spectroscopic features of free radicals produced in gamma irradiation of the N-methyl-dlalanine, N,N -dimethyl glycine hydrochloride and d -( + ) -galactosamine hydrochloride were investigated at room temperature at the dose 15 kGy using EPR technique. The paramagnetic species observed in these compounds were identified as CH 3Ċ HCOOH,ĊHOH(CHOH) 3 NH 2 (CH) 2 O, and (CH 3 ) 2 NĊHCOOH.HCl, respectively. A comparison with a new paramagnetic species recently observed and characterized in irradiated amino acids indicates that the new radical presented here has a similar structure. In this paper, we have also studied the stability of these compounds at room temperature after irradiation.

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EPR study of free radicals in some drugs γ-irradiated in the solid state

Cited by 47 publications

References 9 publications

EPR analysis of gamma irradiated single crystal cimetidine

EPR analysis of gamma irradiated single crystal cimetidine

Study of dose-response and radical decay curves of gamma irradiated norfloxacin using EPR spectroscopy

The effect of gamma radiation of amino acid derivatives in the solid state: an EPR study

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