Eprinomectin in dairy zebu Gobra cattle (Bos indicus): plasma kinetics and excretion in milk

Bengone-Ndong, T.; Ba, Mosidze; Kane, Yaghouba; Sané, I.; Sutra, J.F.; Alvinerie, M.

doi:10.1007/s00436-005-0103-x

Cited by 12 publications

(3 citation statements)

References 19 publications

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“…Pharmacokinetics of eprinomectin following topical administration have been described in both lactating and non-lactating bovine species or breeds, such as Prim Holstein (Alvinerie et al, 1999c), Indian Zebu cattle (Bengone-Ndong et al, 2006) Water Buffaloes (Dupuy et al, 2008) and Aubrac cattle (non-lactating, Lumaret et al, 2005). Pharmacokinetic parameters varied in different bovine species or breeds.…”

Section: Introductionmentioning

confidence: 98%

Plasma and milk kinetics of eprinomectin following topical or oral administration to lactating Chinese Holstein cows

Wen

Pan

Wang

et al. 2010

Veterinary Parasitology

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Section: Introductionmentioning

confidence: 98%

Plasma and milk kinetics of eprinomectin following topical or oral administration to lactating Chinese Holstein cows

Wen

Pan

Wang

et al. 2010

Veterinary Parasitology

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“…The pharmacokinetics of eprinomectin have been described in several bovine species or breeds, including the Prim Holstein (Alvinerie et al ., ), Chinese Holstein (Wen et al ., ), Braunvieh (Rehbein et al ., ), Indian Zebu cattle (Bengone‐Ndong et al ., ), and water buffaloes (Dupuy et al ., ), it has not been reported in lactating yaks. These reports show that the pharmacokinetics of eprinomectin could be quite different in different bovine species or breeds.…”

Section: Introductionmentioning

confidence: 99%

Plasma kinetics, excretion in milk of eprinomectin, and its efficacy against Hypoderma spp. following topical administration in yaks

Shi

Cai³

et al. 2015

Vet Pharm & Therapeutics

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The plasma pharmacokinetics and mammary excretion of eprinomectin were determined in dairy yaks following topical administration at a dose of 0.5 mg/kg. The kinetics of plasma and milk concentrations were analyzed using a noncompartmental model. Plasma and milk concentrations of eprinomectin increased to reach maximal concentrations of 5.45 ± 2.84 and 2.29 ± 0.90 ng/mL at a Tmax of 1.79 ± 0.57 and 2.00 ± 0.82 days, respectively. The concentration of eprinomectin in plasma was remained >0.5 ng/mL for more than 30 days after administration. The mean residence times of eprinomectin in plasma and milk were 14.73 ± 6.22 and 9.37 ± 2.81 days, respectively. The AUC value in plasma (55.89 ± 18.16 ng day/mL) was threefold greater than that in milk (18.02 ± 6.48 ng day/mL). The AUC milk/plasma ratio was 0.33 ± 0.08. The systemic availability of eprinomectin in yaks was lower than that observed value in other domestic bovines. The low level of eprinomectin excretion in milk suggests that eprinomectin can be used in yaks with zero milk-withdrawal time. The efficacy of eprinomectin against naturally acquired larvae of Hypoderma spp. was also determined in yaks. Topically administrated eprinomectin at a dose of 0.5 mg/kg was 100% efficacious against larvae of Hypoderma bovis, H. lineatum, and H. sinense.

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“…Due to the physiological adaptations of zebu Gobra to its environment, drug pharmacokinetics may be different in comparison with other ruminants. It has been demonstrated that the availability of ivermectin and eprinomectin is low in zebu Gobra in comparison to other breeds of cattle (Bengone Ndong et al 2005, 2006. As the antiparasitic activity of macrocyclic lactones depends on drug concentrations and time of parasite exposure to them, an evaluation of the pharmacokinetic profiles may help to estimate and optimize drug efficacy.…”

Section: Introductionmentioning

confidence: 99%

A comparative kinetic study of doramectin and moxidectin in zebu Gobra cattle (Bos indicus)

Bengone-Ndong¹,

Mvouaka²,

Kane³

et al. 2008

Parasitol Res

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The plasma kinetics of doramectin and moxidectin were evaluated in zebu Gobra under field conditions after subcutaneous administration of 0.2 mg kg(-1) of commercially available formulations for cattle. The results indicate that the absorption of moxidectin from the site of injection was significantly faster (absorption half-life [t1/2ab] = 0.7 day) than that of doramectin (t1/2ab = 3.1 days). Moxidectin peak plasma concentration (Cmax) was reached significantly earlier (tmax = 0.4 day) compared with that of doramectin (tmax = 5.3 days). No differences in Cmax values were observed; the area under the concentration-time curve was higher for doramectin (475 ng day ml(-1)) compared with moxidectin (198 ng day ml(-1)), while the mean residence time was longer for moxidectin (13.4 days) compared with doramectin (9.4 days). These results obtained give interesting information on doramectin and moxidectin pharmacokinetics in zebu Gobra, which show a similar pharmacokinetic profile as in other cattle.

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Eprinomectin in dairy zebu Gobra cattle (Bos indicus): plasma kinetics and excretion in milk

Cited by 12 publications

References 19 publications

Plasma and milk kinetics of eprinomectin following topical or oral administration to lactating Chinese Holstein cows

Plasma and milk kinetics of eprinomectin following topical or oral administration to lactating Chinese Holstein cows

Plasma kinetics, excretion in milk of eprinomectin, and its efficacy against Hypoderma spp. following topical administration in yaks

A comparative kinetic study of doramectin and moxidectin in zebu Gobra cattle (Bos indicus)

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