Eprinomectin pour-on: Prevention of gastrointestinal and pulmonary nematode infections in sheep

Eprinomectin nanoemulgel for transdermal delivery against endoparasites and ectoparasites: preparation, in vitro and in vivo evaluation

“…Other than its great therapeutic efficacy against endo-and ectoparasites such as gastrointestinal nematodes, horn fly, and lice (Shoop et al., 1996; Cringoli et al., 2003), it was proved to be safe to lactating dairy animals (Baoliang et al., 2006). The marketed EPR formulation includes topical formulation (EPRINEX ® Pour-on, Merial) and injectable formulation (Eprecis ® 20 mg/mL, Ceva) (Hamel et al., 2018; Termatzidou et al., 2019). However, the Pour-on formulation has weak adhesion and it is administered by pouring along the animals’ back line (Hamel et al., 2018), which may lead to short skin contact time and decrease of efficacy.…”

“…The marketed EPR formulation includes topical formulation (EPRINEX ® Pour-on, Merial) and injectable formulation (Eprecis ® 20 mg/mL, Ceva) (Hamel et al., 2018; Termatzidou et al., 2019). However, the Pour-on formulation has weak adhesion and it is administered by pouring along the animals’ back line (Hamel et al., 2018), which may lead to short skin contact time and decrease of efficacy. Injectable formulation could only be used by technicians who have been trained professionally.…”

Evaluation of the pour-on administration of eprinomectin on milk yield and somatic cell counts in dairy ewes naturally infected with gastrointestinal nematodes

“…Efficacy studies, conducted in sheep ( Hamel et al, 2017 , Hamel et al, 2018 ), goats ( Rehbein et al, 2014 ) and cattle ( Rehbein et al, 2012 ), reported high anthelmintic efficacy of pour-on formulation of eprinomectin, at the recommended dosage, for each of the forementioned animal species. In our study, the efficacy of topically administered eprinomectin was also high (>90%) for the first 42 days post treatment.…”

“…The anthelmintic efficacy of pour-on eprinomectin has been studied in sheep ( Hamel et al, 2017 , Hamel et al, 2018 ), goats ( Rehbein et al, 2014 ) and cattle ( Rehbein et al, 2012 ). However, there is no research establishing the association between treatment of nematode-infected dairy sheep with eprinomectin and their milk yield or somatic cell counts (SCC) in milk.…”