Epstein–Barr Virus and Peri-Implantitis: A Systematic Review and Meta-Analysis

Roca-Millan, Elisabet; Domínguez-Mínger, Judith; Schemel-Suárez, Mayra; Estrugo‐Devesa, Albert; Marí-Roig, Antonio; López‐López, José

doi:10.3390/v13020250

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…However, it appears that bacteria genes encoding resistance to metronidazole are less frequent in peri-implant tissues than those that encode resistance to beta-lactams [34]. In addition, bacteria related to dental implant failure [35] and peri-implantitis [36,37] can be variable and complex, but it consists in part of Gram-negative anaerobic species against which metronidazole is the antibiotic of choice [38,39]. For these reasons, it would be interesting to investigate the effectiveness of metronidazole in reducing dental implant failure.…”

Section: Discussionmentioning

confidence: 99%

Systemic Antibiotic Prophylaxis to Reduce Early Implant Failure: A Systematic Review and Meta-Analysis

et al. 2021

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Systemic antibiotics are routinely prescribed in implant procedures, but the lack of consensus causes large differences between clinicians regarding antibiotic prophylaxis regimens. The objectives of this systematic review are to assess the need to prescribe antibiotics to prevent early implant failure and find the most appropriate antibiotic prophylaxis regimen. The electronic search was conducted in PubMed/MEDLINE, Scielo and Cochrane Central Trials Database for randomized clinical trials of at least 3 months of follow-up. Eleven studies were included in the qualitative analysis. Antibiotics were found to statistically significantly reduce early implant failures (RR = 0.30, 95% CI: 0.19–0.47, p < 0.00001; heterogeneity I2 = 0%, p = 0.54). No differences were seen between preoperative or both pre- and postoperative antibiotic regimens (RR = 0.57, 95% CI: 0.21–1.55, p = 0.27; heterogeneity I2 = 0%, p = 0.37). A single preoperative antibiotic prophylaxis dose was found to be enough to significantly reduce early implant failures compared to no antibiotic (RR = 0.34, 95% CI: 0.21–0.53, p < 0.00001; heterogeneity I2 = 0%, p = 0.61). In conclusion, in healthy patients a single antibiotic prophylaxis dose is indicated to prevent early implant failure.

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Section: Discussionmentioning

confidence: 99%

Systemic Antibiotic Prophylaxis to Reduce Early Implant Failure: A Systematic Review and Meta-Analysis

et al. 2021

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“…Epstein Barr Virus is known to cause Systemic Lupus Erythematosus. A systematic review (Roca-Millan et al, 2021) found no statistically significant difference between peri-implantitis and healthy patients with respect to EBV presence in peri-implant sulcus. A systematic review (Sgolastra et al, 2015) revealed that patients with periodontitis has a moderate risk for peri-implantitis and higher risk for implant loss in contrast to our retrospective study patients with periodontitis may pose a moderate risk to periimplantitis when compared to SLE and RA patients but not significantly higher risk when compared to healthy patients.…”

Section: Discussionmentioning

confidence: 97%

The Association of Rheumatoid Arthritis and Systemic Lupus Erythematosus with Failing Implants

Hsiao¹

2023

SVOADE

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Objectives: Peri-implantitis is a chronic inflammatory disease that affects the bone surrounding the implant. It has become a common problem affecting the long-term survival of the implant with the increased use of implants for replacing the missing teeth. There are few studies that have examined the association between failing implants and Systemic lupus erythematosus (SLE), Rheumatoid Arthritis (RA) and Chronic Periodontitis (CP) with varying conclusions. The aim of this retrospective study is to compare and assess the risk for peri-implantitis in patients with SLE, RA, periodontitis. Materials and Methods: Dental and medical patient records were retrospectively reviewed from electronic health records of Temple University School of Dentistry, Philadelphia, United States between 2008-2021 for peri-implantitis, systemic lupus erythematosus (SLE), Rheumatoid arthritis (RA) and Chronic periodontitis (CP). Peri-implantitis, Periodontitis are diagnosed based on Schwartz criteria and World Workshop 2017 classification. SLE & RA were identified as part of medical history reported by the patient.Results: A total of 1231 patient records were analyzed. 832 patients (67.58%) had at least one systemic disease and 399 patients (32.25%) were systemically healthy patients. 109 patients (13.10%) patients who had systemic condition had peri-implantitis and 86.89% did not have any peri-implantitis. 3 patients with Rheumatoid Arthritis had periimplantitis and only 12 patients with periodontitis had peri-implantitis. 47 Systemic Lupus Erythematosus patients did not have peri-implantitis. Conclusions:The results of the present study indicate that Rheumatoid arthritis, Systemic lupus erythromatosus and Chronic periodontitis did not pose any significant risk of getting peri-implantitis than systemically healthy patients.

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Progress in Designing Therapeutic Antimicrobial Hydrogels Targeting Implant‐associated Infections: Paving the Way for a Sustainable Platform Applied to Biomedical Devices

Dini,

Borges,

Malheiros

et al. 2024

Adv Healthcare Materials

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Implantable biomedical devices have found widespread use in restoring lost functions or structures within the human body, but they face a significant challenge from microbial‐related infections, which often lead to implant failure. In this context, antimicrobial hydrogels emerge as a promising strategy for treating implant‐associated infections owing to their tunable physicochemical properties. However, the literature lacks a comprehensive analysis of antimicrobial hydrogels, encompassing their development, mechanisms, and effect on implant‐associated infections, mainly in light of existing in vitro, in vivo, and clinical evidence. Thus, this review addresses the strategies employed by existing studies to tailor hydrogel properties to meet the specific needs of each application. Furthermore, this comprehensive review critically appraises the development of antimicrobial hydrogels, with a particular focus on solving infections related to metallic orthopedic or dental implants. Then, preclinical and clinical studies centering on providing quantitative microbiological results associated with the application of antimicrobial hydrogels are systematically summarized. Overall, antimicrobial hydrogels benefit from the tunable properties of polymers and hold promise as an effective strategy for the local treatment of implant‐associated infections. However, future clinical investigations, grounded on robust evidence from in vitro and preclinical studies, are required to explore and validate new antimicrobial hydrogels for clinical use.

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Epstein–Barr Virus and Peri-Implantitis: A Systematic Review and Meta-Analysis

Cited by 6 publications

References 35 publications

Systemic Antibiotic Prophylaxis to Reduce Early Implant Failure: A Systematic Review and Meta-Analysis

Systemic Antibiotic Prophylaxis to Reduce Early Implant Failure: A Systematic Review and Meta-Analysis

The Association of Rheumatoid Arthritis and Systemic Lupus Erythematosus with Failing Implants

Progress in Designing Therapeutic Antimicrobial Hydrogels Targeting Implant‐associated Infections: Paving the Way for a Sustainable Platform Applied to Biomedical Devices

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