2007
DOI: 10.1073/pnas.0702332104
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Epstein–Barr virus and virus human protein interaction maps

Abstract: A comprehensive mapping of interactions among Epstein-Barr virus (EBV) proteins and interactions of EBV proteins with human proteins should provide specific hypotheses and a broad perspective on EBV strategies for replication and persistence. Interactions of EBV proteins with each other and with human proteins were assessed by using a stringent high-throughput yeast two-hybrid system. Overall, 43 interactions between EBV proteins and 173 interactions between EBV and human proteins were identified. EBV-EBV and … Show more

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Cited by 358 publications
(399 citation statements)
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“…S3D). This finding is in agreement with the previous observations that viruses tend to target hubs (30).…”
Section: Understanding Healthy To Disease State Transition Using Networksupporting
confidence: 83%
“…S3D). This finding is in agreement with the previous observations that viruses tend to target hubs (30).…”
Section: Understanding Healthy To Disease State Transition Using Networksupporting
confidence: 83%
“…Recently, systems biology approaches have been applied to immunology (1) and pathogen research (2). Significant progress has been made in genome-wide mapping of host-pathogen PPIs for selected pathogens (3)(4)(5)(6)(7)(8). This work has been successful in revealing systematic trends in host-pathogen interaction networks, e.g., that viruses tend to target host protein interaction hubs (2).…”
mentioning
confidence: 99%
“…Certains groupes de recherche, dont le nôtre, cartographient les interactions entre protéines virales et protéines hôtes [12,13], et nous avons entrepris de mesurer quelles interactions protéiques sont perdues ou retenues par les protéines lorsqu'on leur impose des mutations mendélien-nes connues pour être associées au cancer. Ce type d'approche s'inscrit dans le contexte d'une nouvelle discipline qui émerge des sciences théoriques traditionnelles : la science des réseaux.…”
Section: La Science Des Réseaux Une Branche Prometteuse De La Biologunclassified