Epstein-Barr virus-associated T-cell lymphoma: a case of eyelid swelling and intramuscular infiltration mimicking dermatomyositis

Shirasaki, Fumiaki; Taniuchi, Katushige; Matsushita, T.; Hamaguhi, Y.; Takata, Minoru; Takehara, Kazuhiko

doi:10.1046/j.1365-2133.2002.05037.x

Cited by 23 publications

(15 citation statements)

References 15 publications

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“…2, and whose onsets were clear after 20 years of age. Eighteen reported patients were selected as shown in Table 2 [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Analysis Of Reported Casesmentioning

confidence: 99%

Clinical features of adult-onset chronic active Epstein–Barr virus infection: a retrospective analysis

et al. 2011

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We performed a retrospective analysis of patients with adult-onset chronic active Epstein-Barr virus infection (CAEBV). First, we analyzed five patients (aged 28-72) diagnosed at our hospitals with EBV-infected clonally proliferating T cells. Four patients were administered cyclophosphamide/doxorubicin/vincristine/prednisone (CHOP) chemotherapy, but no remarkable decrease of viral load was observed in three of the patients. The other patient died 19 days after initiation of CHOP treatment due to disease progression. Addition of high-dose cytarabine to the regimens of two of the patients was discontinued shortly after administration, due to the development of grade 4 pericardial effusion. Together, these regimens may be insufficient for treating adult-onset CAEBV. We next reviewed 23 adult-onset CAEBV patients, adding 18 previously reported patients to the five patients described in the present study. T cells were frequently infected (87%), whereas NK- and T-cell types are known to be almost equally prevalent in childhood-onset cases. The time duration from the onset of disease to initiation of treatment averaged 20 months. Reports showed that 12 patients died; seven patients died at an average of 8 months after initiation of treatment. Patients' disease courses seemed to be rapidly progressive and more aggressive than those of childhood-onset cases. More cases must be studied to clarify clinical features and establish an optimal treatment strategy.

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“…2, and whose onsets were clear after 20 years of age. Eighteen reported patients were selected as shown in Table 2 [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Analysis Of Reported Casesmentioning

confidence: 99%

Clinical features of adult-onset chronic active Epstein–Barr virus infection: a retrospective analysis

et al. 2011

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“…Many studies have shown that the expression of viral latent genes, especially genes for EBNAs (EBV-associated nuclear antigens) and LMP-1 (latent membrane protein-1), has been closely associated with latent infection that correlates with immortalization and tumorigenesis. In recent years, more evidences show that EBV is found in tumors of bladder [6], breast [7], cervix [8], gastric [9] or gastrointestinal tract [10], kidney [11], lung [12], skin [13], and thyroid [14]. Unfortunately, the role of the virus in the formation of these cancers remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

Detection of EBV Infection and Gene Expression in Oral Cancer from Patients in Taiwan by Microarray Analysis

Yen

Tzeng

et al. 2009

BioMed Research International

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Epstein-Barr virus is known to cause nasopharyngeal carcinoma. Although oral cavity is located close to the nasal pharynx, the pathogenetic role of Epstein-Barr virus (EBV) in oral cancers is unclear. This molecular epidemiology study uses EBV genomic microarray (EBV-chip) to simultaneously detect the prevalent rate and viral gene expression patterns in 57 oral squamous cell carcinoma biopsies (OSCC) collected from patients in Taiwan. The majority of the specimens (82.5%) were EBV-positive that probably expressed coincidently the genes for EBNAs, LMP2A and 2B, and certain structural proteins. Importantly, the genes fabricated at the spots 61 (BBRF1, BBRF2, and BBRF3) and 68 (BDLF4 and BDRF1) on EBV-chip were actively expressed in a significantly greater number of OSCC exhibiting exophytic morphology or ulceration than those tissues with deep invasive lesions (P = .0265 and .0141, resp.). The results may thus provide the lead information for understanding the role of EBV in oral cancer pathogenesis.

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“…Ohtsuka et al 3,8 and Shirasaki et al 9 have reported similar cases with erythematous swelling of the eyelids and intramuscular infiltration mimicking DM that was associated with chronic active EBV infection. The initial clinical manifestations in our patient were also suggestive of DM; namely, bilateral eyelid swelling, erythematous rash over the extremities, and muscular weakness.…”

Section: Discussionmentioning

confidence: 92%

A case of Epstein–Barr virus-associated natural killer/T-cell lymphoma presenting as dermatomyositis: extranodal relapse after 7 years in remission

Hashimoto

Furuta

et al. 2005

Mod Rheumatol

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A 56-year-old Japanese man was admitted to our hospital due to a fever of unknown origin. He had had a history of extranodal natural killer (NK)/T-cell lymphoma, nasal type, and had been in complete remission for 7 years until June 2003, when he developed high fever, eyelid swelling, and muscular weakness. Serum creatine kinase levels were elevated. Histopathological examination of skin and muscle biopsy specimens revealed subcutaneous infiltration of lymphoid cells positive for CD3, CD56, and Epstein-Barr virus-encoded small nuclear RNA-1. We report this unique case of Epstein-Barr virus-associated lymphoma mimicking dermatomyositis.

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Epstein-Barr virus-associated T-cell lymphoma: a case of eyelid swelling and intramuscular infiltration mimicking dermatomyositis

Cited by 23 publications

References 15 publications

Clinical features of adult-onset chronic active Epstein–Barr virus infection: a retrospective analysis

Clinical features of adult-onset chronic active Epstein–Barr virus infection: a retrospective analysis

Detection of EBV Infection and Gene Expression in Oral Cancer from Patients in Taiwan by Microarray Analysis

A case of Epstein–Barr virus-associated natural killer/T-cell lymphoma presenting as dermatomyositis: extranodal relapse after 7 years in remission

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