Epstein Barr virus/complement C3d receptor is an interferon alpha receptor.

Delcayre, Alain; Salas, F. J. S.; Mathur, Satya N.; Kovats, K.; Lotz, Martin; Lernhardt, Waldemar

doi:10.1002/j.1460-2075.1991.tb08025.x

Cited by 119 publications

(67 citation statements)

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“…The extracellular part of the CD21 molecule consists of 15 or 16 SCR domains [1]. The binding sites for C3d, EBV and IFN-a are all localized in the first two SCR [1,3]. A deletion of this region would presumably lead to a CD21 molecule unable to bind EBV.…”

Section: Discussionmentioning

confidence: 99%

“…Structurally, it consists of 15 or 16 extracellular short consensus repeats (SCR) followed by a transmembrane domain and an intracytoplasmic region [1]. CD21 was described as a receptor for the envelope glycoprotein gp350/ 220 of the EBV [2] and also as a receptor for interferon-alpha (IFN-a) [3]. It is found on mature B lymphocytes and follicular dendritic cells [1].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Epstein–Barr virus (EBV) receptor CD21 on peripheral B lymphocytes of long-term EBV− adults

Jabs

Paulsen

Wagner

et al. 1999

Clinical and Experimental Immunology

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SUMMARYPrimary infections with EBV are rarely observed after the age of 20. Some individuals even remain seronegative all their lives. Previously, a lack of EBV receptors on B cells of persistently EBV ¹ adults was described as a reason for long-term EBV-seronegativity. The present study examined the CD21 receptor status of 20 repeatedly EBV ¹ healthy adults and 32 EBV þ volunteers by means of flow cytometry. CD21 molecules on the surface of CD19 þ B cells were quantified using anti-IgG-coated microbeads. The percentage of CD19 þ /CD21 þ B lymphocytes was slightly lower in the peripheral blood of EBV ¹ donors, but the CD21 antibody binding capacity on CD19 þ B cells showed no significant differences between EBV ¹ and EBV þ adults. In vitro studies showed an equally good EBV transformability of peripheral B lymphocytes of EBV ¹ and EBV þ donors. Since HLA-DR was recently described as a co-receptor for EBV infection of B cells, we also determined HLA-DRB1 alleles in the EBV ¹ group. We found a significant negative association of EBV-seronegativity with HLA-DR13 in comparison with 111 healthy blood donors. In summary, a biologically significant lack of the EBV receptor CD21 on peripheral B lymphocytes of persistently EBV ¹ adults was excluded as a reason for long-term EBV-seronegativity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analysis of Epstein–Barr virus (EBV) receptor CD21 on peripheral B lymphocytes of long-term EBV− adults

Jabs

Paulsen

Wagner

et al. 1999

Clinical and Experimental Immunology

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“…It also acts as a cellular receptor for Epstein-Barr virus (EBV) [7,8] and interferon c~ (c~-IFN) [9]. It can be phosphorylated following interaction with its ligands [10,11] and it is involved in important immunoregulatory processes, including *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the C3d homologous regions described on different CR2 ligands (~-IFN, EBV) [9,27,28] have been considered in the CR2 function. However, little is known about the expression of anti-C3d reactive binding sites (hereafter referred as C3d determinants) on CR2 or on proteins of CR2 positive cells, even if it is demonstrated that anti-C3D antibody inhibits the binding of c~-IFN to CR2 [9].…”

Section: Introductionmentioning

confidence: 99%

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Cross‐linking of at least three binding sites mediates signal transduction in a CR2‐positive Burkitt lymphoma derived cell line (Raji)

et al. 1995

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In this study we demonstrate that Raji cells, a CR2-positive Burkitt lymphoma-derived cell line, during cell growth, need the cross-linking of multiple OKB7 binding sites or C3d determinants to mediate signal transduction. The loss of one of these affects the cellular response. Moreover, OKB7, the anti-CR2 MoAb, recognizes C3d determinants on the cell surface and inhibits signal transduetion induced by anti-C3d polyclonal antibody. Since Raji ceils are always CR2 positive during cell growth, we suppose that at least another protein, along with CR2, may be involved in setting up a cell surface complex able to receive and transduce the signal triggered by OKB7. In our experimental system the protein that offers a third binding site to OKB7, may be represented by a 33 kDa protein bearing C3d determinants.

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Association of Blood Concentrations of Complement Split Product iC3b and Serum C3 With Systemic Lupus Erythematosus Disease Activity

Kim

Strand

Sen

et al. 2019

Arthritis & Rheumatology

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Objective To examine correlations between blood levels of complement split product iC 3b and serum component C3 with clinically meaningful changes in disease activity in patients with systemic lupus erythematosus ( SLE ). Methods A total of 159 consecutive patients with SLE , diagnosed according to the American College of Rheumatology or Systemic Lupus International Collaborating Clinics classification criteria, were enrolled in CASTLE (Complement Activation Signatures in Systemic Lupus Erythematosus), a prospective observational study. Patients with 1–7 study visits were included in this longitudinal analysis. In addition, 48 healthy volunteers were enrolled to establish a normal reference value for the ratio of blood iC 3b to serum C3 concentrations. Serum C3 and C4 levels were measured by nephelometry, and blood iC 3b levels were measured by a lateral flow assay. SLE disease activity was monitored with the Responder Index 50 instrument of the SLE Disease Activity Index 2000. Results Relative changes in the iC 3b:C3 ratio, levels of anti–double‐stranded DNA (anti‐ds DNA ) antibodies, and use of a supraphysiologic dose of prednisone (>7.5 mg/day) each independently correlated with SLE disease activity, as determined in multilevel multiple logistic regression analyses. Only the iC 3b:C3 ratio was significantly associated with clinically meaningful improvements in disease activity among patients with SLE who were receiving a supraphysiologic dose of prednisone. The iC 3b:C3 ratio outperformed C3 and C4 levels with regard to discriminating active SLE from inactive SLE , and major flares from no disease activity. The iC 3:C3 ratio, anti‐ds DNA antibody levels, erythrocyte sedimentation rate, and use of a supraphysiologic prednisone dose were each independently associated with the presence of lupus nephritis, whereas none of these measures was associated with SLE rash. The association of the iC 3b:C3 ratio with lupus nephritis was independent of other observed clinical manifestations. Conclusion The ratio of blood iC 3b to serum C3 concentrations correlates with the extent of SLE disease activity and with clinically meaningful changes in disease activity in patients with SLE . Furthermore, the iC 3b:C3 ratio may discriminate between active and inactive...

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Epstein Barr virus/complement C3d receptor is an interferon alpha receptor.

Cited by 119 publications

References 50 publications

Analysis of Epstein–Barr virus (EBV) receptor CD21 on peripheral B lymphocytes of long-term EBV− adults

Analysis of Epstein–Barr virus (EBV) receptor CD21 on peripheral B lymphocytes of long-term EBV− adults

Cross‐linking of at least three binding sites mediates signal transduction in a CR2‐positive Burkitt lymphoma derived cell line (Raji)

Association of Blood Concentrations of Complement Split Product iC3b and Serum C3 With Systemic Lupus Erythematosus Disease Activity

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