Epstein-Barr Virus-Encoded miRNAs in Epstein-Barr Virus-Related Malignancy

Lu, Jun; Chanda, Bidisha; Kotani, Ai

doi:10.5772/39019

Cited by 3 publications

(5 citation statements)

References 77 publications

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“…The more severe, albeit rare, result of EBV infection is malignant transformation and cancer development in various forms, including Burkitt’s lymphoma and nasopharyngeal carcinoma, one of the most common cancers in China. As a ubiquitous human pathogen, EBV-associated lymphoid malignancies include a subset of Burkitt’s lymphoma, AIDS lymphoma, Hodgkin’s lymphoma, posttransplant lymphoma, age-associated B-cell lymphoma and peripheral T- and NK-cell lymphoma ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…In this lytic program, linear double-stranded genomes are produced and packaged as virions that spread the infection from cell to cell. In the latent program, few viral genes are transcribed, no viral progeny are produced and infected cells are protected from apoptotic stimuli and in some circumstances driven to proliferate ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…EBV-encoded micro RNAs originated from the Bam HI fragment H rightward open reading frame 1 (BHRF1) and Bam HI A region rightward transcript (BART) loci of the EB viral genome. These viral micro RNAs play a vital role in immunogenesis, host cell survival and proliferation, differentiation, lymphomagenesis and modulating the states of viral infection and latency ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

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Novel functional small RNAs are selectively loaded onto mammalian Ago1

Yamakawa¹,

Okuyama²,

Ogata³

et al. 2014

Nucleic Acids Research

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Argonaute (Ago) proteins function in RNA silencing as components of the RNA-induced silencing complex (RISC). In lower organisms, the small interfering RNA and miRNA pathways diverge due in part to sorting mechanisms that direct distinct small RNA (sRNA) duplexes onto specific Ago-RISCs. However, such sorting mechanisms appear to be lost in mammals. miRNAs appear not to distinguish among Ago1–4. To determine the effect of viral infection on the sorting system, we compared the content of deep-sequenced RNA extracted from immunoprecipitation experiments with the Ago1 and Ago2 proteins using Epstein–Barr virus (EBV)-infected cells. Consistent with previous observations, sequence tags derived from miRNA loci in EBV and humans globally associate in approximately equivalent amounts with Ago1 and Ago2. Interestingly, additional sRNAs, which have not been registered as miRNAs, were associated with Ago1. Among them, some unique sequence tags derived from tandem loci in the human genome associate exclusively with Ago1 but not, or rarely, with Ago2. This is supported by the observation that the expression of the unique sRNAs in the cells is highly dependent on Ago1 proteins. When we knocked down Ago1, the expression of the Ago1-specific sRNAs decreased dramatically. Most importantly, the Ago1-specific sRNAs bound to mRNAs and regulated target genes and were dramatically upregulated, depending on the EBV life cycle. Therefore, even in mammals, the sorting mechanism in the Ago1–4 family is functional. Moreover, the existence of Ago1-specific sRNAs implies vital roles in some aspects of mammalian biology.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel functional small RNAs are selectively loaded onto mammalian Ago1

Yamakawa¹,

Okuyama²,

Ogata³

et al. 2014

Nucleic Acids Research

Self Cite

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“…EBV was discovered in 1964 by Epstein and Barr et al in lymphoma patients [1] and belongs to γ-herpesvirus, a double-stranded (ds) deoxyribonucleic acid (DNA) virus that infects B lymphocytes [2] and to which the population is generally susceptible. [3] EBV is spread via saliva, leading to infection of oral epithelial cells, followed by infection of B lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

“…The skin lesions of EBV infection are diverse and nonspecific, including EM, pityriasis lichenoides et varioliformis acuta, facial inflammatory granuloma annulare etc. [1,[5][6] Most cases of EM occur after IM symptoms of EBV infection, a few have no prior IM symptoms, and the erythema is often self-limiting. Persistent EM is a rare clinical subtype of EM.…”

Section: Introductionmentioning

confidence: 99%

A chronic EBV infection causing persistent facial erythema multiforme and a retrospective literature review: A case report

Peng

Hui

2022

Medicine

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Rationale: Epstein-Barr virus (EBV) infection is associated with a variety of diseases and can involve multiple organs and systems, with complex and nonspecific clinical manifestations that are easily misdiagnosed. Chronic EBV infection with persistent erythema multiforme (EM) on the cheek as the main manifestation is very rare and has been reported rarely. Patient Concerns: This article reports a case of an adolescent female with chronic EBV infection who presented with chronic symmetrical erythema lesions on the face for 4 years, exacerbated with photophobia, lacrimation, Henoch-Schonlein purpura (HSP)-like rash, decline in granulocyte and erythrocyte lineages, hematuria, and proteinuria for 1 week. Diagnoses: The disease was initially misdiagnosed as systemic lupus erythematosus (SLE) and later confirmed as chronic EBV infection by skin biopsy. In the case, EBV infection not only caused chronic facial EM, but also induced acute HSP and purpura nephritis (hematuria and proteinuria type). Interventions: The child was treated with 1 week of glucocorticosteroids in adequate doses combined with acyclovir antiviral therapy and 3 sessions of hemoperfusion. After discharge, she took prednisone acetate (15 mg twice a day) orally for 1 month and then discontinued. Outcomes: She was discharged with her rash relieved and normal blood routine test and urine routine test. After 13 months of long-term follow-up, her facial erythema and hyperpigmentation became lighter, and there was no new rash on the whole body, and no abnormality in continuous monitoring of complete blood count and urine test. Lessons: This case suggests the need to be alert for chronic EBV infection in adolescent females with chronic facial EM rash and multiple organs and systems injury, in addition to connective tissue diseases such as SLE.

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