Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome.

Kawaguchi, Hiroyuki; Miyashita, Toshiyuki; Herbst, Hermann; Niedobitek, Gerald; Asada, Minoru; Tsuchida, Masahiro; Hanada, R; Kinoshita, Akihiro; Sakurai, Masaharu; Kimura, Noriaki

doi:10.1172/jci116721

Cited by 180 publications

(121 citation statements)

References 32 publications

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“…The majority of previous studies have reported single cases; however, the study by Quintanilla-Martinez et al described the clinicopathological features of 5 cases of this disease (2). In this study, we reviewed the clinicopatho- logical features of 17 cases with systemic EBV-positive T-cell LPD of childhood following acute EBV infection, including the present case (Table I) (2,(4)(5)(6)(7)(8)(9)(10)(11)(12). We revealed that clonal systemic proliferation of EBV-infected T-cells that appear morphologically innocuous with an activated cytotoxic phenotype expressing CD8 and/or CD4 is central to the disease.…”

Section: Discussionmentioning

confidence: 91%

Systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood: Report of a case with review of the literature

et al. 2012

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Section: Discussionmentioning

confidence: 91%

Systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood: Report of a case with review of the literature

et al. 2012

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“…In EBV-related hemophagocytic syndrome, it has been shown that viral-infected T cells release TNF-␣ and activate macrophages, resulting in massive hemophagocytosis. 28,29 These activated T cells might induce polyclonal B-cell activation through cytokine release and thereby induce high levels of IgG and EBV-related antibodies. On the other hand, it is unclear why HMB and high IgE were observed in patients with NK-cell type of CAEBV infection.…”

Section: Discussionmentioning

confidence: 99%

Clinical and virologic characteristics of chronic active Epstein-Barr virus infection

Kimura

Hoshino

Kanegane

et al. 2001

Blood

368

417

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“…Therefore, the viral status in the respective monocytic cell lines obtained may dictate the functional properties of the cells. Some human hemophagocytic syndromes are related to EBV infection (22,26,27). Related to the pathogenesis of this EBV-associated syndrome, enhanced phagocytosis and secretion of TNF-␣ by monocytes/macrophages (31, 40) seemingly result from an activation of their functions by EBV-infected T cells.…”

Section: Discussionmentioning

confidence: 99%

Human Monocytic Cell Lines Transformed In Vitro by Epstein-Barr Virus Display a Type II Latency and LMP-1-Dependent Proliferation

Masy

Adriaenssens²,

Montpellier

et al. 2002

J Virol

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Epstein-Barr virus (EBV) classically infects and transforms B lymphocytes in vitro, yielding lymphoblastoid cell lines (LCLs). In contrast to other herpesviruses, EBV is not described as an infectious agent for monocytes. However, recent papers described in vitro infection of monocytes leading to abortive or transient viral expression. In the present study, we report the characterization of E1, a monocytic cell line infected and transformed by EBV. This cell line was derived from an LCL by a drastic electroporation and selection of neomycin-resistant cells, unfavorable to B-cell outgrowth. E1 expressed surface molecules of monocytic lineage (CD14, major histocompatibility complex class II, and CD80) and the c-fms gene, a highly specific marker for the monocytic lineage. This cell line is able to phagocytose and secrete proinflammatory monokines tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-8. E1 cells are tumorigenic after injection in nude mice, and a monocytic cell line obtained from one of these tumors (TE1) displayed immunophenotype and functional properties similar to those of E1. We detected the presence of the EBV genome in both cell lines, as well as expression of the EBNA-1 and LMP-1, but not EBNA-2, viral genes, characteristic of a type II latency. LMP-1 influences the phenotype of these monocytic cell lines, as demonstrated by down-regulation of cell proliferation and membrane intercellular adhesion molecule 1 expression due to an LMP-1 antisense strategy. This is the first description of a latently infected human monocytic cell line and the first direct demonstration of an instrumental role for LMP-1 in the proliferation of EBV-transformed cell lines expressing a type II latency.

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Epstein-Barr virus-infected T lymphocytes in Epstein-Barr virus-associated hemophagocytic syndrome.

Abstract: The clonal composition of EBV-infected cells was examined in three cases of EBV-associated

Cited by 180 publications

References 32 publications

Systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood: Report of a case with review of the literature

Systemic Epstein-Barr virus-positive T-cell lymphoproliferative disease of childhood: Report of a case with review of the literature

Clinical and virologic characteristics of chronic active Epstein-Barr virus infection

Human Monocytic Cell Lines Transformed In Vitro by Epstein-Barr Virus Display a Type II Latency and LMP-1-Dependent Proliferation

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