Epstein–Barr virus infection causes inflammation in the brain in a rabbit model

Hassani, Asma; Reguraman, Narendran; Philip, Pretty S.; Shehab, Safa; Khan, Gulfaraz

doi:10.1016/j.msard.2021.102997

Cited by 2 publications

(1 citation statement)

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“…EBV is a member of the herpes virus family; it causes mononucleosis and is found in MS, which is defined as a chronic neuroinflammatory condition within the brain ( 200 ). Intravenous peripheral EBV-infected cells break down the BBB, infiltrate the CNS, and trigger neuroinflammation in the rabbit brain ( 201 ). Cytomegalovirus, which is also a cause of chronic immune activation in MS, drives autoimmune-mediated neuroinflammation and demyelination ( 202 , 203 ).…”

Section: Infective Neuroinflammation and Neurodegenerationmentioning

confidence: 99%

Neuroinflammation in neurodegeneration via microbial infections

2022

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Recent epidemiological studies show a noticeable correlation between chronic microbial infections and neurological disorders. However, the underlying mechanisms are still not clear due to the biological complexity of multicellular and multiorgan interactions upon microbial infections. In this review, we show the infection leading to neurodegeneration mediated by multiorgan interconnections and neuroinflammation. Firstly, we highlight three inter-organ communications as possible routes from infection sites to the brain: nose-brain axis, lung-brain axis, and gut-brain axis. Next, we described the biological crosstalk between microglia and astrocytes upon pathogenic infection. Finally, our study indicates how neuroinflammation is a critical player in pathogen-mediated neurodegeneration. Taken together, we envision that antibiotics targeting neuro-pathogens could be a potential therapeutic strategy for neurodegeneration.

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