Epstein-Barr Virus Infectious Mononucleosis in a Splenectomized Patient

Kunimatsu,

doi:10.4021/jmc1254e

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…We have described the case of infectious mononucleosis, serologically verified primoinfection of EBV, in a splenectomized patient with a slightly slower recovery and maintenance of pronounced leukocytosis with lymphocytosis, moderately elevated aminotransferase activity, and generalized maculopapular exanthem [1,[6][7]. We think that, as seen in patients with CMV-IM and EBV-IM, the asplenic condition can significantly alter the classic clinical IM image [2].…”

Section: Discussionmentioning

confidence: 99%

“…However, the main differential diagnostic problem after verification of acute EBV infection by methods available, and the exclusion of acute toxoplasmosis, acute CMV infection, acute HIV infections was still the maintenance of leukocytosis with lymphocytosis, the presence of lymphadenopathy, with night sweats and exhaustion, as well as the absence of febrile. For this reason, we have expanded the diagnostic treatment in terms of observing the acute haematological noninfectious disease [1,8]. Bone marrow biopsy, CT, chest and abdominal analysis of the bone marrow was performed, and acute hematological events were excluded (no further analysis of aspirates-flow cytometry, Southern blot was performed) ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…Clinical picture of the IM mostly consists of the standard triad: elevated temperature, pharyngitis and lymphadenopathy. The usual labaratory results with IM patients include leukocytosis with atypical lymphocytosis, while elevated serum aminotransferase activity appears in 75% of patients with IM, especially in older children and adults [1,6]. Epstein-Barr virus (EBV) is most commonly associated with IM, while other viruses such as Cytomegalovirus (CMV), Human immunodeficiency virus (HIV) and Human herpes virus 6 also can cause IM [1].…”

Section: Introductionmentioning

confidence: 99%

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Infectious mononucleosis in splenectomised patient

Pašić¹,

Kasapović²,

Petrović³

et al. 2019

Acta Med Sal

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Introduction: Infectious mononucleosis is one of the most common syndromes in our clinical practice. It is characterized by elevated temperature, pharyngitis and generalized lymphadenopathy. Objectives: To describe a clinical charachteristics of infectious mononucleosis (IM) caused by the Epstein Barr virus (EBV) in splenectomized patients since in the literature we found insufficient data. Subjects and Methods: Retrospective analysis of medical documentation of the patient treated in the Clinic for Infectious Diseases of the University Clinical Center of Republic of Srpska. Results: We have described the case of infectious mononucleosis, caused by Epstein Barr virus in a splenectomized patient. In support of acute EBV viral infection were the presence of lymphadenopathy, pharyngitis, hepatomegaly, as well as the occurrence of a typical generalized maculopapulous rash, and positive ELISA EBV VCA IgM and anti EBV VCA / EA IgG, were reported. According to the aforementioned patient, it fulfilled most criteria for setting the diagnosis of acute EBV infectious mononucleosis. Our patient showed some atypical signs such as absence of fever during hospitalization, marked leukocytosis with lymphocytosis (with a maximum increase in leukocyte count at 37.3 x 10 9 , in the differential blood sample dominated lymphocytes with 29.96 x 10 9 (reference values 1.1-3.35), i.e. 80.3% (Ref. 20.0-46.0). Due to the maintenance of leukocytosis with lymphocytosis, the range of clinical has been extended trials (US abdomen, US neck, CT neck, chest, abdomen and pelvis, sternal puncture, hematologists' consultation). Based on the aforementioned hematologists' consultation, and post-release and recovery monitoring it is concluded that there has been no sign of acute hematologic disease but it has been just EBV-IM. Conclusion: Because of insufficient data on clinical presentation of Epstein Barr viral infections in splenectomized this we believe that this is one of the clinical variants although the possibility of individual variation cannot be excluded. Briefly, we can conclude that the immune system in the splenectomized patient can greatly modify the clinical presentation of Epstein barr viral infection, with the pathogenic mechanism that are still unclear.. However, due to the variety of clinical syndromes and the oncogenic potency of the Epstein-Barr virus, we should be extremely cautious and sometimes expand the diagnostic range beyond conventional examinations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Infectious mononucleosis in splenectomised patient

Pašić¹,

Kasapović²,

Petrović³

et al. 2019

Acta Med Sal

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Methisoprinol as an immunomodulator for treating infectious mononucleosis

Maharani

2016

Dent. J. (Majalah Kedokteran Gigi)

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Background: Infectious mononucleosis (IM) is the self limiting disease that associated with primary Epstein Barr virus (EBV). It is a gamma herpes virus. EBV infection is follows saliva-transfer by kissing or sexual intercourse. The most clinical manifestation in IM consists mainly of the specific sign: pharyngitis, fever, and lymphadenopathy. The main therapy is supportive treatment. Actually the antiviral therapy is required for the host with high response immune. Purpose: The aimed of this study was to report the therapy of IM using methisoprinol. Case: The woman patient, 33 years old, came to hospital by suffering pharyngitis and swolen on left neck. It had been since 3 days ago. Case management: She had come to Puskesmas that were given amoxycillin capsul 500 mg three times a day for three days and paracetamol tablet 500mg three times a day for three days, but she was still ill. Then she came to RSGM Hasan Aman Banjarmasin. She was diagnosed as IM. The instruction were isolation and bed rest for a week. She had to eat sofly and drink water highly. The therapy were amoxycillin capsul 500 mg three times a day for seven days, methisoprinol caplet 500 mg three times a day for seven days, natrium dikofenak tablet 50 mg three times a day for seven days. She was asked to see the dentist next 7 days. In this case, she were not given acyclovir. Conclusion: IM is self limiting disease. IM is the disease with spesific clinical syndrome that associated with primary EBV infection. Depend on the base of clinical experiences, the supportive treatment is adviced for patient of IM. Methisoprinol has both immunomodulator and antiviral properties.

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Epstein-Barr Virus Infectious Mononucleosis in a Splenectomized Patient

Cited by 2 publications

References 8 publications

Infectious mononucleosis in splenectomised patient

Infectious mononucleosis in splenectomised patient

Methisoprinol as an immunomodulator for treating infectious mononucleosis

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