Equilibrium and Kinetic Studies of the Reactions between Aqua[1‐(2‐aminoethyl)piperazine]palladium(II) and Biologically Relevant Nucleophiles

Abstract

The kinetics and mechanism of the complex-formation reactions of [Pd(AEP)(H 2 O)] 2+ , where AEP stands for 1-(2-aminoethyl)piperazine, with biologically relevant ligands were studied as a function of selected nucleophiles and pH. The reactivity of the ligands follows the sequence L-methionine Ͼ guanosine-5Ј-monophosphate Ͼ glycine Ͼ inosine ϾϾ glutathione. The substitution reactions with glutathione showed two reaction steps in which the first step involves coordination through nitrogen and depends on the nucleophile concentration, whereas the second step involves intra-

Complex formation reactions of palladium(II)-1,3-diaminopropane with various biologically relevant ligands. Kinetics of hydrolysis of glycine methyl ester through complex formation

“…The purines like inosine have two metal ion binding centres N 1 and N 7 nitrogens. The pH dependent binding of these N-donors was already reported [27]. The results showed that inosine forms the complexes 110 and 111.…”

Speciation studies on the complex formation reactions of [Pd(N,N-diethyl-ethylendiamine)(H2O)2]2+ with some bio-relevant ligands and displacement reaction by mercaptoethylamine

“…Therefore, Pd(II) complexes are good models for the analogous Pt(II) complexes in solution. Recent work in our laboratories focused on the equilibria of complex-formation reactions of cis-(diamine)PdCl 2 [4][5][6][7][8][9][10][11][12]. In this study, a chelated ligand, N,N-diethylethylenediamine was used.…”

Speciation studies of mono- and binuclear Pd(II) complexes involving mixed nitrogen–sulfur donor ligand and 4,4′-bipiperidine as a linker

“…We have a long-standing interest in equilibria of complex-formation reactions of (diamine)PdCl 2 [21][22][23][24][25][26][27] and dinuclear palladium(II) [28,29] complexes with bio-relevant ligands. It will be of interest to extend these investigations and study the mono-and binuclear complexes with N,S-donor ligands.…”