Equilibrium swelling behavior of pH-sensitive hydrogels

Brannon-Peppas, Lisa; Peppas, Nikolaos A.

doi:10.1016/0009-2509(91)80177-z

Cited by 468 publications

(347 citation statements)

References 19 publications

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“…However, the difference of swelling degree over the pH range studied in this work is rather low. Similar results were observed by Brannon-Peppas and Peppas [41]. On the other hand, hydrogels of p(HEMA-co-DPA) show a significant increase of…”

Section: Drug Release Experimentssupporting

confidence: 88%

Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Faccia¹,

Pardini²,

Amalvy³

2015

Express Polym. Lett.

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Section: Drug Release Experimentssupporting

confidence: 88%

Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Faccia¹,

Pardini²,

Amalvy³

2015

Express Polym. Lett.

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“…In the highly alkaline environment of hydrating cement (with typical pH of 12-13, well above the pKa of acrylic acid, ≈4.25), the acrylic acid groups within the chemical structure of the hydrogel will deprotonate [26], allowing the resultant negatively charged moieties to complex with large amounts of water via ion-dipole interactions [27,28]. However, it is these same negative charges that can electrostatically interact with the various mono-and multivalent cations [29][30][31] (e.g., sodium, potassium, calcium) that are naturally found inside fresh cement mixtures as a result of the hydration reaction [23].…”

Section: Introductionmentioning

confidence: 99%

Improved Concrete Materials with Hydrogel-Based Internal Curing Agents

Krafcik

Macke

Erk

2017

Gels

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This research article will describe the design and use of polyelectrolyte hydrogel particles as internal curing agents in concrete and present new results on relevant hydrogel-ion interactions. When incorporated into concrete, hydrogel particles release their stored water to fuel the curing reaction, resulting in reduced volumetric shrinkage and cracking and thus increasing concrete service life. The hydrogel's swelling performance and mechanical properties are strongly sensitive to multivalent cations that are naturally present in concrete mixtures, including calcium and aluminum. Model poly(acrylic acid(AA)-acrylamide(AM))-based hydrogel particles with different chemical compositions (AA:AM monomer ratio) were synthesized and immersed in sodium, calcium, and aluminum salt solutions. The presence of multivalent cations resulted in decreased swelling capacity and altered swelling kinetics to the point where some hydrogel compositions displayed rapid deswelling behavior and the formation of a mechanically stiff shell. Interestingly, when incorporated into mortar, hydrogel particles reduced mixture shrinkage while encouraging the formation of specific inorganic phases (calcium hydroxide and calcium silicate hydrate) within the void space previously occupied by the swollen particle.

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“…A reduction in pH would lead to swelling in a basic polymer-based hydrogel. This swelling response of pH-sensitive hydrogels has been rigorously analysed by Brannon-Peppas in terms of FloryHuggins and rubber elasticity theory, with added contributions from ionic interaction [135]. pH-responsive hydrogels are considered strong candidates for drug delivery due to their potential in sensing and targeting [12].…”

Section: Chemicalmentioning

confidence: 99%

Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms

2016

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Shape-changing materials open an entirely new solution space for a wide range of disciplines: from architecture that responds to the environment and medical devices that unpack inside the body, to passive sensors and novel robotic actuators. While synthetic shape-changing materials are still in their infancy, studies of biological morphing materials have revealed key paradigms and features which underlie efficient natural shape-change. Here, we review some of these insights and how they have been, or may be, translated to artificial solutions. We focus on soft matter due to its prevalence in nature, compatibility with users and potential for novel design. Initially, we review examples of natural shape-changing materials-skeletal muscle, tendons and plant tissues-and compare with synthetic examples with similar methods of operation. Stimuli to motion are outlined in general principle, with examples of their use and potential in manufactured systems. Anisotropy is identified as a crucial element in directing shape-change to fulfil designed tasks, and some manufacturing routes to its achievement are highlighted. We conclude with potential directions for future work, including the simultaneous development of materials and manufacturing techniques and the hierarchical combination of effects at multiple length scales.

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Equilibrium swelling behavior of pH-sensitive hydrogels

Cited by 468 publications

References 19 publications

Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs

Improved Concrete Materials with Hydrogel-Based Internal Curing Agents

Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms

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