Equine hepacivirus persistent infection in a horse with chronic wasting

Elia, Gabriella; Lanave, Gianvito; Lorusso, Eleonora; Parisi, Antonio; Trotta, Adriana; Buono, Raffaele; Martella, Vito; Decaro, Nicola; Buonavoglia, Canio

doi:10.1111/tbed.12679

Cited by 15 publications

(27 citation statements)

References 16 publications

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“…In contrast, EqHV and EqPV‐H are hepatotropic and have frequently been detected in cases of mild or subclinical hepatitis 2,20,21 . EqHV infection has only been reported in three cases of severe clinical liver disease 22‐24 . EqHV was associated with chronic, severe hepatopathy in two cases 23,24 and detected in one case of acute severe hepatitis 22 .…”

Section: Equine Acute Hepatitismentioning

confidence: 99%

“…In contrast, EqHV and EqPV-H are hepatotropic and have frequently been detected in cases of mild or subclinical hepatitis [2; 20; 21]. EqHV infection has only been reported in three cases of severe clinical liver disease [22][23][24].…”

Section: Accepted Articlementioning

confidence: 99%

“…EqHV infection has only been reported in three cases of severe clinical liver disease 22‐24 . EqHV was associated with chronic, severe hepatopathy in two cases 23,24 and detected in one case of acute severe hepatitis 22 . However, two of these cases were published before the detection of EqPV‐H, and no EqPV‐H testing was performed 22,24 .…”

Section: Equine Acute Hepatitismentioning

confidence: 99%

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Equine parvovirus hepatitis

Ramsauer

Badenhorst

Cavalleri

2021

Equine Veterinary Journal

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Section: Equine Acute Hepatitismentioning

confidence: 99%

Section: Accepted Articlementioning

confidence: 99%

Section: Equine Acute Hepatitismentioning

confidence: 99%

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Equine parvovirus hepatitis

Ramsauer

Badenhorst

Cavalleri

2021

Equine Veterinary Journal

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“…Until now, whether EqHV infection is associated with liver disease remains unclear. However, it has been reported that horses infected with EqHV could developed severe hepatitis and chronic wasting[ 9 , 10 ]. EPgV and TDAV were first discovered in horses in the USA in 2013[ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Identification and genetic characterization of hepacivirus and pegivirus in commercial equine serum products in China

Huang

Yang

et al. 2017

PLoS ONE

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Equine hepacivirus (EqHV), equine pegivirus (EPgV) and Theiler’s disease-associated virus (TDAV) are three novel equine viruses in the family Flaviviridae. EqHV and EPgV have been identified to circulate in the equine population worldwide, whereas TDAV has not been detected in equines since the first reported case. To date, no studies have focused on investigating EqHV, EPgV and TDAV in commercial equine sera or equine blood products in China. Considering the potential threat of EqHV, EPgV and TDAV to biosecurity and considering their possible influences on research results, equine sera for cell culture propagation and pregnant mare serum gonadotropin (PMSG) were purchased from different companies in China and investigated for EqHV, EPgV and TDAV in this study. By performing nested PCR or two rounds of PCR targeting the viral NS3 gene, four serum samples were confirmed to be EqHV-, EPgV-, or TDAV-RNA positive; all of the PMSG samples were negative for these three viruses. Subsequent sequencing results indicated that the serum samples contained multiple viral variants of EqHV, EPgV or TDAV, and a genetic analysis based on the partial NS3 gene of the three equine viruses was performed. Our study is the first to confirm the presence of EqHV, EPgV and TDAV in equine sera for cell culture propagation that is commercially available in China and provides the first demonstration of the presence of TDAV in China.

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“…Similar to equine hepacivirus (EqHeV), which has been classified into different subtypes by multi‐target genome analysis (Elia et al., 2017; Lu, Ou, Sun, et al, 2019; Pronost et al., 2017), BovHepV also shows a marked genetic diversity with geographic‐derived patterns observed in the circulating strains (Lu et al., 2018). By applying the criteria adopted for HCV genotyping and subtyping to the available complete BovHepV genomes, it has been proposed to classify BovHepV strains as a single genotype (genotype 1) and four different subtypes (A to D).…”

Section: Introductionmentioning

confidence: 99%

Genetic heterogeneity of bovine hepacivirus in Italy

Elia

Caringella

Lanave

et al. 2020

Transbound. Emerg. Dis.

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Viruses similar to human hepatitis C virus (HCV) in the Hepacivirus genus have been identified in several animal hosts, including cattle. Since its first discovery in Germany, bovine hepacivirus (BovHepV) has been described in several countries globally. However, limited data are available on BovHepV epidemiology and genetic variability. The aim of this study was to investigate the prevalence and genetic diversity of BovHepV in Italy. Viral RNA was identified in 37 (0.15%) of 24,820 bovine sera, with titres ranging from 1.09 × 10 3 to 8.27 × 10 6 RNA copies/ml. Upon sequencing and phylogenetic analysis of the 5′UTR and NS3 genomic portions, the Italian BovHepV strains segregated into at least four distinct subtypes (A, B, C and F) that are also co-circulating globally.

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Equine hepacivirus persistent infection in a horse with chronic wasting

Cited by 15 publications

References 16 publications

Equine parvovirus hepatitis

Equine parvovirus hepatitis

Identification and genetic characterization of hepacivirus and pegivirus in commercial equine serum products in China

Genetic heterogeneity of bovine hepacivirus in Italy

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