Equine meniscal degeneration is associated with medial femorotibial osteoarthritis

Dubuc, J.; Girard, Christiane; Richard, Hélène; Lasalle, Julie De

doi:10.1111/evj.12716

Cited by 19 publications

(28 citation statements)

References 32 publications

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“…Meniscal injury has been associated with equine medial femorotibial disease, including MFC SBCs both before and after treatment . This is the first report examining the mechanical impact of a MFC void on the equine meniscus.…”

Section: Discussionmentioning

confidence: 93%

“…We believe that the changes in the meniscus stress that occur with an MFC SBC may explain some meniscal injuries because our model predicts an increase of about 30% in peak tension and shear on the meniscus when an MFC void is present. This increase in stress occurs in the meniscal body, a common location of injury (Figure ), and may be exacerbated when the loaded stifle is flexed . Two previous studies have measured contact pressure ex vivo on the proximal tibia under the equine medial meniscus, but they did not agree on the shape of the pressure maps.…”

Section: Discussionmentioning

confidence: 99%

“…Sagittal rotation (joint flexion) was constrained to consider outcomes in stifle extension, a likely position when MFC damage occurs. Preliminary finite element results allowing frontal plane rotation (varus/valgus angulation) produced increased pressure in the lateral femorotibial joint and were at odds with clinical stifle lameness and anatomic observations, so varus/valgus rotation was constrained. This decision is supported by a kinematic analysis of an unloaded, nearly complete equine stifle that suggests that frontal plane rotation is limited in terminal extension .…”

Section: Discussionmentioning

confidence: 99%

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Impact of a void in the equine medial femoral condyle on bone stresses and peak contact pressures in a finite element model

2018

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Objective: To predict bone and medial meniscal stresses and contact pressures in an equine stifle with a medial femoral condyle (MFC) intact or with a 2-cm 3 subchondral bone void, under varying degrees of internal femoral rotation (IFR). Study design: Finite element model (FEM) of a cadaveric equine stifle loaded to 8000 N. Methods: The FEM was constructed from computed tomography (CT) of the right, extended stifle of a yearling. The CT image was segmented into relevant anatomic structures and meshed into 4-node tetrahedrons. Bone material properties were assigned according to Hounsfield units, soft tissue properties were estimated from published data, and the model was loaded to 8000 N in 155 extension. Results: The main stresses found in the intact MFC were in compression, with very small areas of shear and tension. Adding a 2-cm 3 MFC void increased peak compression stress by 25%, shear by 50%, and tension by 200%. An MFC void also increased tension and shear placed on the medial meniscus by 30%. Under load, IFR of 2.5 and 5 increased MFC peak stresses 8%-21%. Conclusion: A 2-cm 3 MFC void in an equine stifle FEM increased stress in the bone and meniscus. Internal femoral rotation slightly increased predicted bone stress. Clinical significance: Increases in bone and meniscal stress predicted in an MFC with a void provide evidence to understand the persistence of voids and mechanism of damage to the medial meniscus.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impact of a void in the equine medial femoral condyle on bone stresses and peak contact pressures in a finite element model

2018

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“…Unfortunately, it is di cult to obtain enough pathological tissues in small animals (mouse, rat, and rabbit), particularly on an eroded cartilage surface. However, large animals (horse and bovid) are di cult to manage and breed [6,7]. Diannan small-ear pig is a kind of mini pig produced in Yunnan with the average maturation age of 8 months.…”

Section: Introductionmentioning

confidence: 99%

Comparative effectiveness of two methods for inducing osteoarthritis in a novel animal model, the Diannan small-ear pig1

Jia

Cai

et al. 2020

Preprint

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Abstract Background: Varieties of animals were used to study osteoarthritis pathogenesis. The Diannan small-ear pig, which is native to Yunnan, China, is thought to have an articular anatomy similar to that of humans and is more likely to be a source of pathological tissues than other animals. The aim of this study was determine whether this animal can serve as a more effective osteoarthritis model.[A1] Methods: Twenty-seven adult pigs were randomly divided into three groups and underwent the Hulth procedure, papain articular injection [A2] , and conventional breeding. After 4, 8, and 12 weeks, cartilage tissues from knee joint were extracted for general and histological observation, immunofluorescence, and biochemical analysis. [A3] Synovium was taken out for stromal cell-derived factor-1 analysis. Results: Histopathological observation showed obvious cartilage loss in two experimental groups, this cartilage loss was more severe in the chemical groups. Synovial stromal cell-derived factor1 levels increased over time in all groups. mRNA and protein levels of matrix metalloproteinase-3 were much higher in the chemical groups than in the other groups, whereas levels of collagen type II[A4] and aggrecan were significantly lower in the chemical groups than in the other groups. Immunofluorescence assays of collagen type II[A5] revealed an apparent reduction in this marker in the chemical groups compared with the other groups. Conclusions: These results indicated that the Diannan small-ear pig can be used as an effective osteoarthritis model. In addition, it is much more convenient and much faster to induce osteoarthritis by intra-articular injection of papain, which is a method worthy of being promoted.

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“…This study found that meniscal lesions were identified in all segments of this structure, and affected both articular surfaces. A significant association was demonstrated between meniscal degeneration and OA severity, however, the relationship between OA and meniscal pathology remains to be elucidated [24].…”

mentioning

confidence: 98%

Clinical insights: Recent developments in equine articular disease (2016–2018)

Clegg

2018

Equine Veterinary Journal

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Equine meniscal degeneration is associated with medial femorotibial osteoarthritis

Cited by 19 publications

References 32 publications

Impact of a void in the equine medial femoral condyle on bone stresses and peak contact pressures in a finite element model

Impact of a void in the equine medial femoral condyle on bone stresses and peak contact pressures in a finite element model

Comparative effectiveness of two methods for inducing osteoarthritis in a novel animal model, the Diannan small-ear pig1

Clinical insights: Recent developments in equine articular disease (2016–2018)

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