Equine multinodular pulmonary fibrosis (EMPF): Five case reports

Schwarz, Bettina; Klang, Andrea; Bezděková, B.; Sárdi, Sára; Kutasi, Orsolya; Hoven, R. van den

doi:10.1556/avet.2013.024

Cited by 15 publications

(30 citation statements)

References 17 publications

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“…Although we did not test our oral and gastrointestinal specimens for the presence of gammaherpesvirus, positive EHV-5 PCR on BAL specimens proved the pulmonary presence of the virus, which possibly could emerge in all other tissues. Chronic weight loss is also one of the typical clinical signs in EMPF caused by EHV-5 [16].…”

Section: Discussionmentioning

confidence: 99%

Systemic Granulomatous Disease in a Hungarian Warmblood Gelding

Kutasi

Moravszki

Sárdi

et al. 2014

Journal of Equine Veterinary Science

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a b s t r a c tAn 8-year-old Hungarian warmblood gelding used for show jumping was evaluated because of poor performance and chronic weight loss. On admission, oral and gastroesophageal ulcerations and malabsorption were detected. Results of thoracic radiography, ultrasonography, bronchoalveolar lavage cytology, and positive polymerase chain reaction for equine herpesvirus 5 raised the possible diagnosis of equine multinodular pulmonary fibrosis. However, abdominal ultrasonography revealed inhomogeneous spleen with many different sized well-demarcated hypoechoic areas, which suggested further differential diagnoses such as tuberculosis, neoplasias, immune mediated diseases, systemic granulomatous disease (SGD), or toxicoses. The horse was euthanized at the owner's request because of the poor condition and possible grave prognosis. Histopathology findings were characteristic of SGD, which is a rare disorder of horses characterized by skin lesions, weight loss, and granulomatous inflammation of multiple organ systems. The lack of skin lesions in this case is an unusual finding. Systemic granulomatous disease is hypothesized to be induced by multiple conventional antigens that are not cleared from affected tissues. Equine herpesvirus 5 might have triggered the granulomatous reactions in this particular case.

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Section: Discussionmentioning

confidence: 99%

Systemic Granulomatous Disease in a Hungarian Warmblood Gelding

Kutasi

Moravszki

Sárdi

et al. 2014

Journal of Equine Veterinary Science

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“…Large animal models, using ferret, pig and sheep have been described with phenotypes that appear more congruent with human pulmonary fibrosis [140][141][142][143][144]. Further, naturally occurring pulmonary fibrosis models exist [37,38,[145][146][147][148][149][150][151][152], which may offer insights into pathogenesis and systems to test therapeutic agents.…”

Section: Pulmonary Fibrosismentioning

confidence: 99%

Optimising experimental research in respiratory diseases: an ERS statement

Bonniaud¹,

Fabre²,

Frossard³

et al. 2018

Eur Respir J

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Experimental models are critical for the understanding of lung health and disease and are indispensable for drug development. However, the pathogenetic and clinical relevance of the models is often unclear. Further, the use of animals in biomedical research is controversial from an ethical perspective.The objective of this task force was to issue a statement with research recommendations about lung disease models by facilitating in-depth discussions between respiratory scientists, and to provide an overview of the literature on the available models. Focus was put on their specific benefits and limitations. This will result in more efficient use of resources and greater reduction in the numbers of animals employed, thereby enhancing the ethical standards and translational capacity of experimental research.The task force statement addresses general issues of experimental research (ethics, species, sex, age, and models, gene editing). The statement also includes research recommendations on modelling asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, lung infections, acute lung injury and pulmonary hypertension.The task force stressed the importance of using multiple models to strengthen validity of results, the need to increase the availability of human tissues and the importance of standard operating procedures and data quality.

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“…Lung biopsy may therefore assist with the diagnosis of EMPF and provides a sample for histopathology and viral PCR testing for EHV-5 in such cases. 26,27 Biopsy of lung in patients with chronic and severe RAO may be done as well to characterize the degree of pulmonary fibrosis that is present. This information may allow the practitioner to understand what degree of respiratory The operator must be ready to clamp off the drain at all times to avoid pneumothorax when effusion is no longer draining from the tube.…”

Section: Lung Biopsymentioning

confidence: 99%