Equivalent circuit models for a biomembrane impedance sensor and analysis of electrochemical impedance spectra based on support vector regression

Xu, Ying; Li, Chao; Mei, Wanxin; Guo, Miao; Yang, Yong

doi:10.1007/s11517-019-01970-7

Cited by 19 publications

(9 citation statements)

References 33 publications

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“…It must be noted, however, the QLSA performs the calculation of the spectra corresponding to all the different available ENBs in parallel. This means, for instance, that even if we focus on ENB10 for fLF = 10 mHz, as in the example discussed above, spectra corresponding ENB9, ENB8, and so on are being calculated as well and, because of Equation (23), estimates corresponding to lower index ENBs become available before the first estimate for a higher index ENB is available. This means that by observing the estimates obtained for lower index ENBs as they become available, if consistent data are obtained for increasing indexes, one can stop the measurement before the estimate for the targeted high index ENB is obtained, thus saving time.…”

Section: Preliminary System Testingmentioning

confidence: 99%

“…Although it is well established that these variations of behavior occur from frequencies close to dc up to frequencies in the order of MHz (and, in some cases, GHz), the frequency range of 10 kHz-100 kHz has been considered the most suitable for BIS measurements [17][18][19][20] and the frequency of 50 kHz [21] has often been chosen for data interpretation. Other researchers have lowered the minimum investigation frequency to 100 Hz [22,23]. This implies that bio-impedance measurements have so far neglected the effects due to the so-called α dispersion [16], which takes into account the relaxation of ions surrounding the charged cellular membrane and which dominates the impedance behavior from 0 Hz to a few hundred Hertz.…”

Section: Introductionmentioning

confidence: 99%

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Portable and Highly Versatile Impedance Meter for Very Low Frequency Measurements

et al. 2021

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Electrical Impedance Spectroscopy (EIS) is a characterization technique that is gaining more and more importance in various fields of research and applications. The frequency range of investigation varies according to the type of application. In some fields (biology, medicine, energy) it is useful to be able to perform measurements at very low frequency values (down to a few mHz or even below). While impedance meters operating at frequencies in the range from a few tens of Hz up to a few MHz can be regarded as quite standard pieces of instrumentation commonly available in many laboratories, instrumentation for measurements at very low frequencies, although commercially available, is less common. The subject of this work is the design, realization and testing of a low frequency impedance measurement platform that has the advantage of being portable, rather inexpensive, and yet highly versatile. In our approach, we exploit a personal computer and a soundboard as a powerful system for digital signal generation and analysis that, with the help of low complexity and low-cost external hardware and a public domain software for the implementation of the core system, allow to tailor the platform for targeting specific applications with minimal effort. As an example, we will demonstrate the application of the system to the investigation of polypyrrole-based supercapacitor structures.

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Section: Preliminary System Testingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Portable and Highly Versatile Impedance Meter for Very Low Frequency Measurements

et al. 2021

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“…We evaluated the efficacy of the fabricated IWE for the real-time impedance monitoring of the bacteria by measuring the impedance spectra using different concentrations of NaCl as electrolyte in a frequency range from 10 Hz to 1 kHz, as shown in Figure 2 . The electrical impedance characteristic of the electrode was governed by a sinusoidal signal with a frequency lower than 100 kHz applied to the electrodes; the bulk capacitance could be neglected, and the equivalent circuit can be simply designed using only an electrical conductivity of the bulk medium (R s ) and the double-layer capacitance (CPE) in series [ 33 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

Interdigitated and Wave-Shaped Electrode-Based Capacitance Sensor for Monitoring Antibiotic Effects

Park

Lee

Hwang

et al. 2020

Sensors

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Label-free and real-time monitoring of the bacterial viability is essential for the accurate and sensitive characterization of the antibiotic effects. In the present study, we investigated the feasibility of the interdigitated and wave-shaped electrode (IWE) for monitoring the effect of tetracycline or kanamycin on Staphylococcus aureus (S. aureus) and methicillin-resistant S.aureus (MRSA). The electrical impedance spectra of the IWE immersed in the culture media for bacterial growth were characterized in a frequency range of 10 Hz to 1 kHz. The capacitance index (CI) (capacitance change relevant with the bacterial viability) was used to monitor the antibiotic effects on the S. aureus and MRSA in comparison to the traditional methods (disk diffusion test and optical density (OD) measurement). The experimental results showed that the percentage of change in CI (PCI) for the antibiotic effect on MRSA was increased by 51.58% and 57.83% in kanamycin and control, respectively. In contrast, the PCI value decreased by 0.25% for tetracycline, decreased by 52.63% and 37.66% in the cases of tetracycline and kanamycin-treated S. aureus, and increased 2.79% in the control, respectively. This study demonstrated the feasibility of the IWE-based capacitance sensor for the label-free and real-time monitoring of the antibiotic effects on S.aureus and MRSA.

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“…A potential is induced across the WE and RE, while the CE provides a steady current supply. Randles cell [24] is an equivalent circuit model for an electrode in an electrolyte and is illustrated in Fig. 1.…”

Section: A Electrodesmentioning

confidence: 99%

Concurrent Potentiometric and Amperometric Sensing With Shared Reference Electrodes

Ghoreishizadeh

Georgiou

2021

IEEE Sensors J.

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Potentiometry and amperometry are the two most common electrochemical sensing methods. They are conventionally performed at different times, although new applications are emerging that require their simultaneous usage in a single electrochemical cell. This paper investigates the feasibility and potential drawbacks of such a setup. We use a potentiometric and an amperometric sensor to compare their output signals when they are used individually, as well as when they are combined together with a shared reference electrode. Our results in particular show that potentiometric readings with a shared reference electrode show a high correlation of 0.9981 with conventional potentiometry. In the case of amperometric sensing, the cross correlation of the simultaneous versus individual measurement is 0.9959. Furthermore, we also demonstrate concurrent measurement for potentiometry in the presence of cell current through the design of innovative test systems. This is done through measuring both varying pH values and varying concentrations of H 2 O 2 to showcase the operation of the circuit.

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Equivalent circuit models for a biomembrane impedance sensor and analysis of electrochemical impedance spectra based on support vector regression

Cited by 19 publications

References 33 publications

Portable and Highly Versatile Impedance Meter for Very Low Frequency Measurements

Portable and Highly Versatile Impedance Meter for Very Low Frequency Measurements

Interdigitated and Wave-Shaped Electrode-Based Capacitance Sensor for Monitoring Antibiotic Effects

Concurrent Potentiometric and Amperometric Sensing With Shared Reference Electrodes

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